Colorectal Dis. 2021 Apr 26. doi: 10.1111/codi.15690. Online ahead of print.
ABSTRACT
AIM: The aim was to investigate the influence of distal resection margin and extent of mesorectal excision on long-term oncological outcomes.
DESIGN: Consecutive patients with upper and middle third rectal cancer from June 2006 to February 2016 were reviewed. Patients were divided into four groups depending on the distal margin considered as a surrogate marker of the extension of mesorectal excision (Q1: ≤ 10mm, Q2: 11-20mm, Q3: 21-30mm, Q4: ≥ 31mm).
MAIN OUTCOME MEASURES: Local recurrence-free survival (LRFS), disease-free survival (DFS) and overall survival (OS) were estimated. Cox regression models were used to investigate the influence of surgical and clinicopathological variables on prognosis by adjusting for confounding factors.
RESULTS: 211 patients with mid (125) and upper (86) rectal cancer underwent wide mesorectal excision. The median follow-up was 48.64 months (IQR: 28-63). 17.5% patients developed recurrence. The 5-year LRFS, DFS and OS for all patients were 93.20 %, 83.89% and 80.1%, respectively with no statistical significant differences among groups (DFS, p= 0.487; LRFS, p= 0.601; OS, p=0.468). At the multivariable analysis the recurrences and survival were associated with the quality of the mesorectum (LRFS, HR: 10.629 CI 95% 2.324-48.610; p=0.002; DFS, HR: 2.789 CI 95% 1.314-5.922; p:0.008).
CONCLUSION: A wide anatomical resection with partial mesorectal excision and shorter distal resection margin does not jeopardize the oncological outcomes.
PMID:33900002 | DOI:10.1111/codi.15690
