Int J Clin Pract. 2021 Apr 30:e14292. doi: 10.1111/ijcp.14292. Online ahead of print.
ABSTRACT
BACKGROUND: The objective of the study was to evaluate the serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β and interleukin (IL)-6 in Chronic HBV-Infected patients.
METHODS: The present study was a single center, prospective, and randomized controlled trial. Twenty healthy volunteers and 30 HBeAg-negative patients with planned liver biopsy and treatment-naive diagnosed with Chronic hepatitis B (CHB) were included in the study. TNF-α, IL-1β, and IL-6 levels were measured in the serum of CHB patient and control groups using an ELISA. Results were compared statistically using a Mann Whitney U-test.
RESULTS: The mean age of the CHB group (20 men, 10 women) and the control group (10 men, 10 women) was 33.3 ± 9.7 (17-55) and 26.1 ± 12.3 (16-57), respectively. When the two groups were compared with the Mann Whitney U-test, TNF-α and IL-6 levels were found to be significantly higher in the CHB group compared to the control group (p = 0.003, p < 0.0001, respectively.). Although IL-1β levels were not statistically significant, they were higher in the CHB group compared to the controls (p = 0.07).
CONCLUSIONS: The results of our study showed that serum levels of TNF-α and IL-6 are increased in CHB patients.
PMID:33930244 | DOI:10.1111/ijcp.14292
