Arthritis Care Res (Hoboken). 2023 Apr 11. doi: 10.1002/acr.25127. Online ahead of print.
ABSTRACT
OBJECTIVE: To investigate the relationship between sleep disturbance, catastrophizing, and knee pain in middle-aged and older persons.
DESIGN: Data from the Osteoarthritis Initiative (OAI) cohort from months 48 to 96 were used, where month 48 was treated as baseline. Knee pain (the Western Ontario and McMaster Osteoarthritis Index [WOMAC] pain scale ≥5, 0-20), catastrophizing (extracted from the Coping Strategies Questionnaire [CSQ] ≥3, 0-6), and sleep quality (extracted from the Center for Epidemiologic Studies Depression Scale [CES-D], 1-4) were assessed annually. We described the association of sleep disturbance with the presence and risk of knee pain and catastrophizing. The mediation effect of knee pain and catastrophizing on sleep-catastrophizing and sleep-pain association was evaluated, respectively.
RESULT: Catastrophizing and knee pain were reported in 346 (10%) and 917 (24%) of the 3813 participants (mean 64.9 years, 58% female) at baseline. Participants with worse sleep disturbance were more likely to have knee pain (prevalence ratios [PR]1.4-2.0, Ptrend <0.001) and catastrophizing (PR 1.4-3.1, Ptrend <0.001). Sleep disturbance at baseline predicted the risk of knee pain (risk ratios [RR] 1.1, Ptrend <0.001) and catastrophizing (RR 1.2-1.7, Ptrend <0.001) during the follow-up. No statistically significant interactions between sleep disturbance and knee pain or catastrophizing were observed. Knee pain and catastrophizing mediated the sleep-catastrophizing and sleep-pain association respectively at baseline, and knee pain negatively mediated the sleep-catastrophizing association longitudinally.
CONCLUSION: Sleep disturbance was associated with the presence and risk of catastrophizing and knee pain. Sleep interventions may have a universal and independent effect in preventing incident knee pain.
PMID:37038964 | DOI:10.1002/acr.25127
