Tissue Eng Part C Methods. 2023 Apr 21. doi: 10.1089/ten.TEC.2023.0025. Online ahead of print.
ABSTRACT
The aim of this study was to test the suitability of calcium phosphate cement mixed with poly(lactic-co-glycolic acid microparticles (CPC-PLGA) into a ring-shaped polymeric space-maintaining device as bone graft material for lateral bone augmentation. Therefore, the bone chambers were installed on the lateral portion of the anterior region of the mandibular body of mini-pigs. Chambers were filled with either calcium phosphate cement mixed with poly(lactic-co-glycolic acid microparticles (CPC-PLGA) or BioOss® particles for comparison and left for 4 and 12 weeks. Histology and histomorphometry were used to obtain temporal insight in material degradation and bone formation. Results indicated that between 4 and 12 weeks of implantation, a significant degradation of the CPC-PLGA (from 75.1% to 23.1%) as well as BioOss® material occurred (from 40.6% to 14.4%). Degradation of both materials was associated with the presence of macrophage-like and osteoclast-like cells. Further, a significant increase in bone formation occurred between 4 and 12 weeks for the CPC-PLGA (from 0.1% to 7.2%) as well as BioOss® material (from 8.3% to 23.3%). Statistical analysis showed that bone formation had progressed significantly better using BioOss® compared to CPC-PLGA (p<0.05). In conclusion, this mini-pig study showed that CPC-PLGA does not stimulate lateral bone augmentation using a bone chamber device. Both treatments failed to achieve “clinically” meaningful alveolar ridge augmentation.
PMID:37082957 | DOI:10.1089/ten.TEC.2023.0025
