Eur J Endocrinol. 2023 May 26:lvad058. doi: 10.1093/ejendo/lvad058. Online ahead of print.
ABSTRACT
BACKGROUND: Thyroid dysfunction (hypo- and hyperthyroidism) has been reported as a late effect after hematopoietic stem cell transplantation (HSCT) in children. Short term effects of HSCT on thyroid function parameters are, however, unclear.
METHODS: We prospectively evaluated thyroid function parameters before and three months after HSCT in all children (<21 years) who underwent HSCT during a two-year period in the Princess Máxima Center, the Netherlands.
RESULTS: Among 72 children, none had thyroidal hypothyroidism or hyperthyroidism three months after HSCT. Changes in thyroid function parameters (either aberrant TSH or FT4 concentrations) were found in 16% before and in 10% three months after HSCT. Reverse T3 was found elevated in 9.3% before and in 37% three months after HSCT, which could be related to poor physical condition. An individual decline in FT4 concentration of ≥20% was found in 10.5% (6/57) three months after HSCT.
CONCLUSION: In conclusion, thyroidal hypo- and hyperthyroidism are very rare three months after HSCT. These results indicate that surveillance for hypo- and hyperthyroidism may start later in time. The changes in thyroid function parameters found three months after HSCT might reflect the euthyroid sick syndrome.
PMID:37232272 | DOI:10.1093/ejendo/lvad058
