JPEN J Parenter Enteral Nutr. 2023 Jun 25. doi: 10.1002/jpen.2540. Online ahead of print.
ABSTRACT
OBJECTIVES: The objective of the study was to compare body composition of children with intestinal failure measured using bioelectrical impedance analysis (BIA) and skinfolds to dual energy x-ray absorptiometry (DXA). DXA is the reference method for body composition assessment in clinical settings.
METHODS: Children 1-18 years with intestinal failure, having a DXA as part of routine clinical monitoring were eligible. BIA measured total body water on the same day as DXA. Skinfold measurements were taken at four sites: triceps, biceps, subscapular, and suprailiac. Percent fat- and fat-free mass (FFM) were derived from resistance and reactance measured by BIA using age-specific equations. Percent fat-mass (FM) was calculated from skinfold measures using age-specific equations. Data on subject characteristics, intestinal failure related factors and feeding method were collected. Paired T-test examined differences in %FM and %FFM and Bland Altman analysis determined agreement between BIA, skinfolds and DXA. Marginal linear model assessed the effect of age, sex and feeding method on the difference in body composition obtained between DXA and BIA, and DXA and skinfolds.
RESULTS: Sixty-eight children with intestinal failure, mean age 8.9±4.2 years, were studied. There was no difference between %FFM and %FM obtained by DXA and BIA (p=0.26), with a mean bias (95% CI) of -0.69(-1.9, 0.5)% for %FFM. Sex and age were individually and jointly associated with the bias observed between DXA and BIA (p<0.05). Skinfold and DXA measurements were significantly different (p<0.05).
CONCLUSIONS: BIA is an acceptable clinical tool for assessing body composition in pediatric intestinal failure. This article is protected by copyright. All rights reserved.
PMID:37355855 | DOI:10.1002/jpen.2540
