Int J Infect Dis. 2023 Oct 1:S1201-9712(23)00733-6. doi: 10.1016/j.ijid.2023.09.019. Online ahead of print.
ABSTRACT
OBJECTIVES: This study aimed to identify factors deterring secondary household transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from SARS-CoV-2-positive cohabitants.
METHODS: A case-control study was conducted with 272 healthcare workers in close contacts with SARS-CoV-2-positive cohabitants. Logistic regression modeling was employed to determine the factors independently associated with secondary household transmission.
RESULTS: A SARS-CoV-2 infection within the past 6 months was the most protective factor against secondary household transmission (adjusted odds ratio = 0.07, 95% confidence interval: 0.01-0.61, P < 0.05). Home isolation and older age of primary index case (7-12, ≥18 years) were also associated with a reduced risk. Both monovalent and bivalent messenger ribonucleic acid booster vaccinations exhibited potential protective tendencies, but were not statistically significant. Additionally, bivalent vaccines did not demonstrate a clear advantage over monovalent vaccines.
CONCLUSION: A recent history of SARS-CoV-2 infection, home isolation of positive cohabitants, and older age of primary index cases were positively associated with a reduced risk of secondary household transmission. Regarding booster vaccinations, data from a single center with a limited sample size may not capture all statistically significant differences, necessitating broader studies.
PMID:37788740 | DOI:10.1016/j.ijid.2023.09.019
