Developing an exclusive sensor based on molecularly imprinted polymer/Multi-walled carbon nanotubes/Fe3O4@Au nanocomposite for the selective determination of an anti-cancer drug imatinib

Chemosphere. 2023 Oct 13:140450. doi: 10.1016/j.chemosphere.2023.140450. Online ahead of print.

ABSTRACT

Determination of pharmaceuticals especially anticancer drugs is one of the important issues in environmental and medical investigation and creating good information about human health. The presence sturdy introducing an electroanalytical sensor based on molecularly imprinted polymer (MIP)/Multi-walled carbon nanotubes (MWCNTs)/Au@Fe₃O₄ nanoparticles modified carbon paste electrode (PE) to determine imatinib (IMA). The MIP/MWCNTs/Au@Fe₃O₄/PE showed catalytic activity and also a sensitive strategy to sensing IMA in the concentration range 1-1000 μM with a limit of detection of 0.013 μM. The MIP/MWCNTs/Au@Fe₃O₄/PE has shown interesting results in the analysis of IMA in real samples, and the interference investigations results show the high selectivity of the MIP/MWCNTs/Au@Fe₃O₄/PE in the monitoring of IMA in complex fluids such as tablet and blood serum and results approved by F-test and t-test as statistical methods.

PMID:37839746 | DOI:10.1016/j.chemosphere.2023.140450