Georgian Med News. 2021 Apr;(313):163-168.
ABSTRACT
Aim of the research – to study the features of the structural reconstruction of blood vessels of the testes of experimental animals at arterial hypertension in the pulmonary circulation using a complex of morphological methods. Experiments were carried out on 78 laboratory sexually mature white male rats, which were divided into 3 groups. The 1 group included 15 intact practically healthy animals, 2 – 48 rats with hypertension in the pulmonary circulation and compensated cor pulmonale, 15 animals with pulmonary hypertension, which developed decompensation of cor pulmonale, constituted the 3 group. Arterial hypertension in the pulmonary circulation was simulated by performing a right-sided pulmonectomy. Three months after the beginning of the experiment, the rats were euthanized by bloodletting under thiopental anesthesia. Histological micropreparations were made from the testes, on which the morphometry of arteries, veins, and microvessels was performed. Quantitative indicators were processed statistically. It was revealed that postresection hypertension in the pulmonary circulation leads to structural reconstruction of arteries, microvessels, and the venous bed of the left and right testes. At the same time, the degree of remodeling of the studied vessels dominates in the microhemocirculatory bed of the left testis at decompensation of the cor pulmonale. Structural reconstruction of the vessels of the microhemocirculatory bed of the testes in case of insufficiency of the cor pulmonary is characterized by a pronounced narrowing of the arterioles, precapillary arterioles), exchange (hemocapillaries) links of the microhemocirculatory bed and the expansion of postcapillary venules and venules, venous plethora, hypoxia, impaired trophism and metabolism, dystrophy, necrobiosis of cells, tissues, infiltration and sclerosis.
PMID:34103450
