Photodermatol Photoimmunol Photomed. 2021 Jun 22. doi: 10.1111/phpp.12709. Online ahead of print.
ABSTRACT
BACKGROUND: Photodynamic therapy for hidradenitis suppurativa (HS) is a therapeutic alternative with a good safety profile, but its effectiveness has yet to be demonstrated.
OBJECTIVES: To demonstrate the effectiveness of PDT with intralesional methylene blue in HS lesions.
METHODS: A retrospective cross-sectional study was performed. Forty-one patients were treated with intralesional methylene blue and a diode lamp. Follow-up was carried out at 1 and 6 months after therapy. Efficacy was determined by the diameter reduction of the lesion measured by high-frequency ultrasound.
RESULTS: A reduction of ≥75% in the maximum diameter was recorded in 58.5% of the lesions, while 22% showed a reduction between 50 and 75%, and 19.5% showed a reduction of <50 %. Recurrence rate was 12,5%. The lesions treated in patients with typical forms of HS (Canoui-Poitrine phenotype I) had a better therapeutic response. No statistically significant differences were found in terms of lesion location or concomitant treatment.
CONCLUSION: This therapy may potentially be a cost-effective and well-tolerated local therapy for Hurley I-II patients with superficial abscesses and fistulas.
PMID:34157160 | DOI:10.1111/phpp.12709
