Alzheimer Dis Assoc Disord. 2024 Oct-Dec 01;38(4):351-357. doi: 10.1097/WAD.0000000000000648. Epub 2024 Nov 13.
ABSTRACT
BACKGROUND: Previous studies were examined effects of social restriction by COVID-19 pandemic on elderly peoples or compared difference of before/after restrictions on patients with Alzheimer disease-related dementia (ADRD). Here, we assessed the effects of restrictions on the cognitive function of the patients by comparing control group.
METHODS: We examined the impact on cognitive function using the Alzheimer Disease Assessment Scale (Japanese version) cognitive subscale (ADAS-JCOG), in patients with mild to moderate ADRD by a post hoc subgroup analysis of double-blinded, noninferiority study of donepezil 27.5 mg patches and donepezil hydrochloride 5 mg tablets (JapicCTI-194582). After demonstrating the noninferiority of both treatments, we used combined data for this analysis.
RESULTS: The analyzed subpopulation of the per-protocol set groups was balanced (n=126 and 135, respectively). Patient demographics were similar between subgroups. The difference of ADAS-JCOG scores [least-squares mean (95%CI)] between the groups was 0.388 (-0.377 to 1.152, not statistically significant).
CONCLUSION: Social isolation affects cognitive function on ADRD and this knowledge should be considered in future.
PMID:39588690 | DOI:10.1097/WAD.0000000000000648
