Toxicol Rep. 2024 Nov 4;13:101799. doi: 10.1016/j.toxrep.2024.101799. eCollection 2024 Dec.
ABSTRACT
BACKGROUND: Oral isotretinoin is a powerful medication commonly used for treating severe Acne valgaris, particularly in cases that are resistant to conventional therapies like topical treatments and antibiotics. It is a retinoid derived from vitamin A, known for its ability to significantly reduce sebum production, prevent clogged pores, and decrease inflammation.
OBJECTIVE: This study investigates the changes in liver function tests and lipid profiles before and after the use of oral isotretinoin among Acne Vulgaris clients.
METHOD: A quantitative retrospective study was conducted using electronic medical records from 50 Acne Vulgaris patients aged 13-40 years who received oral isotretinoin at Ibri Polyclinic between 2012 and 2022. The obtained data were analyzed using SPSS version 20.
RESULTS: The analysis revealed significant changes in liver function tests, with elevated levels of total bilirubin and ALT post-treatment. Lipid profiles also showed marked alterations, including increased cholesterol, LDL, HDL, and triglyceride levels.
CONCLUSION: The findings highlight the substantial impact of isotretinoin on liver function and lipid metabolism in Acne Vulgaris patients. Further research is needed to explore the mechanisms behind isotretinoin-induced hepatotoxicity and dyslipidemia, potentially guiding future interventions.
PMID:39606776 | PMC:PMC11600753 | DOI:10.1016/j.toxrep.2024.101799
