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Interim Estimates of 2024-2025 Seasonal Influenza Vaccine Effectiveness – Four Vaccine Effectiveness Networks, United States, October 2024-February 2025

MMWR Morb Mortal Wkly Rep. 2025 Feb 27;74(6):83-90. doi: 10.15585/mmwr.mm7406a2.

ABSTRACT

Annual influenza vaccination is recommended for all persons aged ≥6 months in the United States. Interim influenza vaccine effectiveness (VE) was calculated among patients with acute respiratory illness-associated outpatient visits and hospitalizations from four VE networks during the 2024-25 influenza season (October 2024-February 2025). Among children and adolescents aged <18 years, VE against any influenza was 32%, 59%, and 60% in the outpatient setting in three networks, and against influenza-associated hospitalization was 63% and 78% in two networks. Among adults aged ≥18 years, VE in the outpatient setting was 36% and 54% in two networks and was 41% and 55% against hospitalization in two networks. Preliminary estimates indicate that receipt of the 2024-2025 influenza vaccine reduced the likelihood of medically attended influenza and influenza-associated hospitalization. CDC recommends annual receipt of an age-appropriate influenza vaccine by all eligible persons aged ≥6 months as long as influenza viruses continue to circulate locally.

PMID:40014791 | DOI:10.15585/mmwr.mm7406a2

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