Regen Med. 2025 May 20:1-9. doi: 10.1080/17460751.2025.2507504. Online ahead of print.
ABSTRACT
AIM: To evaluate the effectiveness of a bioregenerative scaffold created from bone marrow aspirate, cancellous bone autograft, platelet-rich plasma, and autologous fibrin in treating complicated non-unions of the supracondylar femur, humeral shaft, and radius and ulna.
METHODS & MATERIALS: Three patients with non-unions resulting from multiple surgical failures underwent bone stabilization along with the application of a novel bioregenerative scaffold. X-rays and subjective assessments were collected prior to surgery and at 6- and 12-months post-surgery.
RESULTS: All non-unions demonstrated healing with adequate callus formation, as confirmed by radiological assessments. By 12 months, all patients were able to resume full weight-bearing activities or regain full range of motion and physical strength without pain. Statistical analysis revealed improvements across all assessment scales compared to pre-surgical values.
CONCLUSION: This approach offers a viable option for treating complex long bone non-unions after multiple surgical interventions.
PMID:40391486 | DOI:10.1080/17460751.2025.2507504
