Indian J Pathol Microbiol. 2025 Jun 7. doi: 10.4103/ijpm.ijpm_749_24. Online ahead of print.
ABSTRACT
BACKGROUND: Head-neck carcinoma, which includes oral squamous cell carcinoma (OSCC), is the eighth most common type of cancer. Secretarial for most head and neck cancers, this being one of the primary causes of morbidity and destruction worldwide. Included in OSCC are extranodal extension and depth of invasion and their relation with pTNM staging, which are essential to OSCC prognosis. These histopathological features can be incorporated into pathology data to provide further appropriate treatment for OSCC patients.
MATERIALS AND METHODS: Records of 65 patients were retrieved from the departmental archives and histopathological characteristics were studied. Statistical analysis was done and histopathologic parameters were correlated.
RESULTS: The Present study aimed to find a correlation between the extranodal extension of positive lymph nodes and depth of invasion histopathologically in tumors to rule out its impact on the survival and prognosis of patients. On correlating DOI with ENE, it showed that 27 patients had positive lymph nodes 15 patients having a DOI more than 10 mm showed extranodal extension and 9 patients showed negative ENE, suggesting a significant correlation between both parameters (p-0.008).
CONCLUSION: We hypothesized that there was a significant correlation between extracapsular spread and depth of invasion in OSCC and has an effect on the survival and prognosis of the patient.
PMID:40485490 | DOI:10.4103/ijpm.ijpm_749_24
