Int J Surg. 2025 Jun 24. doi: 10.1097/JS9.0000000000002645. Online ahead of print.
ABSTRACT
BACKGROUND: Peripheral nervous system tumors are abnormal proliferations originating from neural tissues (such as the nerve sheath and nerve fibers), classified as either benign or malignant. Common subtypes encompass schwannomas, neurofibromas, and malignant peripheral nerve sheath tumors. Notably, malignant peripheral nerve sheath tumors are characterized by their high malignancy potential and have demonstrated a concerning rise in both incidence and mortality rates in recent epidemiological studies.
METHODS: Based on the Global Burden of Disease (GBD) 2021 database, we conducted a statistical analysis of the trends of incidence, disability-adjusted life years (DALYs) per 100,100 population along with 95% uncertainty intervals(UIs), as well as deaths among adults aged 70 years and older from 1990 to 2021 in peripheral nervous system tumors. The date were subjected to stratified analyses across age, sex, socio-demographic index (SDI), 21 regions, and 204 countries. A Bayesian age- period- cohort (BAPC) model incorporating integrated nested Laplace approximations was applied to forecast the disease burden up to 2050. On a global scale, all stratified analyses demonstrated a consistent trajectory trend in incidence, DALYs, and deaths among older adults, with projections indicating this trend is likely to persist until 2050.
RESULTS: Over the past three decades (1990-2021), the incidence rates of peripheral nervous system tumors have risen by 185%, with disability-adjusted life years (DALYs) rates increasing by 164% and deaths rates climbing by 167%. Notably, high SDI regions exhibited declining trends in incidence rates (-10.1%), DALYs rates (-14.3%), and mortality rates (-11.6%) after 2003, low- and middle SDI regions maintained annual increases. A significant gender reversal occurred in 2021, where male incidence numbers, DALYs and deaths numbers surpassed female rates. Bayesian age-period-cohort (BAPC) modelling predicts a 2.0-fold increase in ASIR by 2050 relative to 2021 levels, with DALY and mortality burdens projected to rise 2.2-fold and 1.8-fold respectively under current trajectories.
CONLUSION: The analysis results revealed that there were pronounced disparities across SDI regions, with high-middle SDI regions shouldering the greatest burden. These findings underscore the urgent need for region-specific prevention and control strategies to address the growing epidemiological and socioeconomic impacts of these malignancies in aging populations.
PMID:40557436 | DOI:10.1097/JS9.0000000000002645
