J Cosmet Dermatol. 2025 Jul;24(7):e70326. doi: 10.1111/jocd.70326.
ABSTRACT
BACKGROUND: Hyperpigmentation and periorbital dark circles remain challenging dermatological concerns due to their multifactorial etiology, including vascular, pigmentary, and structural components. This study evaluates the efficacy of a novel multi-action topical formulation designed to target hyperpigmentation and skin aging through a synergistic blend of active ingredients.
OBJECTIVE: To assess the objective and clinical effects of a dermatological composition containing niacinamide, arbutin, tranexamic acid, ubiquinone, a DHEA-like component, curcuma oily extract, and marine exopolysaccharides on periorbital hyperpigmentation and skin quality.
METHODS: Subjects with visible under-eye dark circles applied the formulation twice daily over a treatment period of 6 weeks. The evaluation included instrumental quantitative assessments of skin pigmentation along with standardized imaging. A separate safety study and cosmetic efficacy questionnaire of patient experience were completed.
RESULTS: The formulation demonstrated statistically significant improvements in pigmentation intensity. The twice daily use of the under-eye serum resulted in an average overall reduction in under-eye hyperpigmentation of 47.94%, with no adverse effects observed.
CONCLUSION: This novel topical composition offers a safe and effective multi-targeted approach for improving periorbital hyperpigmentation and promoting overall skin rejuvenation. The synergistic action of its active components supports its use in clinical and aesthetic dermatology for the treatment of dark circles and age-related changes.
PMID:40626342 | DOI:10.1111/jocd.70326
