Imaging Neurosci (Camb). 2024 Jul 29;2:imag-2-00240. doi: 10.1162/imag_a_00240. eCollection 2024.
ABSTRACT
How does the human brain generate coherent, subjective perceptions-transforming yellow and oblong visual sensory information into the perception of an edible banana? This is a hard problem. According to the standard viewpoint, processing in groups of dedicated regions-identified as active “blobs” when using functional magnetic resonance imaging (fMRI)-gives rise to perception. Here, we reveal a new organizational concept by discovering that stimulus-specific information distributed throughout the whole brain. Using fMRI, we found stimulus-specific information across the neocortex, even in voxels previously considered “noise,” challenging traditional analytical approaches. Surprisingly, these stimulus-specific signals were also present in the subcortex and cerebellum and could be detected from across-subject variances. Finally, we observed that stimulus-specific signal in brain regions beyond the primary and secondary sensory cortices is influenced by sedation levels, suggesting a connection to perception rather than sensory encoding. We hypothesize that these widespread, stimulus-specific, and consciousness level-dependent signals may underlie coherent and subjective perceptions.
PMID:40800543 | PMC:PMC12272199 | DOI:10.1162/imag_a_00240
