Hypertens Res. 2025 Aug 20. doi: 10.1038/s41440-025-02335-4. Online ahead of print.
ABSTRACT
Exercise is well known to reduce the risk of cardiovascular diseases and mortality. However, studies in individuals with chronic kidney disease (CKD) are limited. This study used large population-based data to investigate the differences in the impact of exercise habits on all-cause and cardiovascular mortality between individuals with and without CKD. This study included participants from the Japan Specific Health Checkups (J-SHC) Study conducted between 2008 and 2014. The exposure of interest was self-reported daily exercise habits. The association between exercise habits and all-cause and cardiovascular mortality was examined using Cox regression analysis based on the CKD status. Of the 469,466 participants, 84,508 (18.0%) had CKD, and 39,343 (46.6%) exercised. During the median follow-up period of 44.0 months, 3932 (2.76/1000 person-years) and 1505 (5.09/1000 person-years) participants died in the non-CKD and CKD cohorts, respectively. Exercise habits were associated with a lower risk of all-cause mortality in the non-CKD and CKD cohorts, with adjusted hazard ratios and 95% confidence intervals of 0.80 (0.75-0.86) and 0.70 (0.63-0.78), respectively. The effect of exercise habits on mortality was greater in the CKD group (P for interaction = 0.02). Similar results were observed for cardiovascular mortality. Regular exercise was more strongly associated with decreased all-cause and cardiovascular mortality in individuals with CKD than in those without. Our study highlights the need for individuals with mild CKD to prioritize exercise habits over those without CKD.
PMID:40836032 | DOI:10.1038/s41440-025-02335-4
