Indian J Tuberc. 2025 Oct;72(4):465-470. doi: 10.1016/j.ijtb.2025.02.016. Epub 2025 Feb 25.
ABSTRACT
BACKGROUND: TB Preventive Treatment (TPT) is considered as an effective intervention to reduce TB incidence by reducing the pool of TB infection in the community. This study was aimed to assess TPT outcome and its associations in West Bengal.
METHOD: ology: A retrospective cohort study conducted using the data from Ni-kshay, the web-based TB information management portal of India. All TPT beneficiaries who have initiated with TPT in the year 2022 were included in the study. To find out the independent risk factor associated with unsuccessful outcome, risk ratio (RR) and adjusted risk ratio (aRR) has been calculated using regression models.
RESULTS: Median age and BMI of the participants were 32 years, & 20.9 kg/m2 respectively. Median delay to TPT initiation from diagnosis of the index TB patients was 23 days. 90.5% (90.2-90.7) outcomes were successful while 9.5% (9.3-9.8) outcomes were unfavourable. 0-9yrs (aRR = 1.31), 10-19yrs (aRR = 1.16) & 20-39yrs (aRR = 1.10) age-groups were more likely to be associated with unsuccessful TPT outcomes. Overweight (aRR = 1.10) & Obese (aRR = 1.19) were associated with unsuccessful outcomes. Participants belong to urban areas (aRR = 1.37) & attending Private Health Facility (aRR = 1.17) were more likely to be associated with an unsuccessful outcome. TPT initiation delay of 8-30 days (aRR = 2.03) and >30 days (aRR = 2.90) was associated with unsuccessful TPT outcomes.
CONCLUSION: There are few gaps as well as few opportunities in the TPT programs in West Bengal. Gaps are both in policy level as well as implementation level. Identified gaps should be addressed for a better TB preventive strategy in West Bengal.
PMID:40975575 | DOI:10.1016/j.ijtb.2025.02.016
