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Inhibition of butyrylcholinesterase in a population exposed to insecticides during a campaign against Aedes aegypti

Trans R Soc Trop Med Hyg. 2025 Oct 6:traf108. doi: 10.1093/trstmh/traf108. Online ahead of print.

ABSTRACT

BACKGROUND: Chemical control remains a widely used strategy to reduce morbidity from vector-borne diseases such as dengue. However, the potential health risks to exposed populations necessitates ongoing monitoring, particularly due to the toxicity and volume of insecticides employed.

METHODS: This study assessed butyrylcholinesterase activity in residents of a city in southern Mexico during distinct periods of exposure to carbamate and organophosphate insecticides.

RESULTS: A statistically significant inhibition of enzymatic activity was observed during the rainy season, which coincided with an increase in insecticide application.

CONCLUSIONS: These findings highlight the need for public health authorities to implement preventative measures aimed at minimizing poisoning risks associated with vector control activities.

PMID:41048036 | DOI:10.1093/trstmh/traf108

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