Pediatr Pulmonol. 2025 Oct;60(10):e71284. doi: 10.1002/ppul.71284.
ABSTRACT
OBJECTIVE: The purpose of this study was to investigate the risk factors for chronic coughing in children diagnosed with mycoplasma pneumoniae pneumonia (MPP) and provide a reference for a foundation for clinical diagnosis and therapy.
METHODS: A retrospective analysis was conducted by gathering pertinent clinical data from children with MPP who were hospitalized in the First Affiliated Hospital of Zhengzhou University. Relevant clinical data were collected during their hospitalization. At least 4 weeks after discharge from the hospital, the children were followed up by telephone and outpatient clinic to determine whether they had developed chronic cough. The number of sequential courses of azithromycin and the duration of the out-of-hospital nebulizer treatment were recorded. Results 28 cases (14.9%) with chronic cough among the 188 children with MPP were included in the case group, while 160 cases (85.1%) were included in the control group. Age, C reactive protein (CRP), CT feature, Mycoplasma antibody titers, the number of sequential courses of azithromycin and the number of days of nebulization therapy in the case group were statistically different from those in the control group (p < 0.05). Through logistic regression analysis, we found that the history of atopic constitution, serum IgE levels, the number of sequential courses of azithromycin, and the number of days of nebulization therapy influenced chronic cough in MPP children. (p < 0.05).
CONCLUSION: Our findings indicate a potential association between atopic constitution and the development of chronic cough in MPP children, and suggest that sequential azithromycin and nebulization therapy might help reduce the likelihood of chronic cough.
PMID:41147253 | DOI:10.1002/ppul.71284
