J Dermatolog Treat. 2025 Dec;36(1):2583235. doi: 10.1080/09546634.2025.2583235. Epub 2025 Nov 6.
ABSTRACT
BACKGROUND: Optimizing acute wound care after resurfacing lasers is essential for healing, downtime, and cosmetic outcomes. Demand for effective topicals has led to use of various products.
OBJECTIVE: This study compares the efficacy of silicone-based fluid gel versus white paraffin ointment in managing acute post-resurfacing laser wounds.
METHODS: In this intra-individual, split-face study, 15 patients treated for acne scars applied silicone gel to one facial half and white paraffin to the other. Two blinded dermatologists assessed acute reactions using the VISIA Complexion Analysis system. Patient satisfaction was measured with two tools.
RESULTS: The silicone-treated side showed greater erythema, pruritus, scaling, and crusting than the paraffin side, though differences were not statistically significant. VISIA demonstrated significantly worse redness, higher porphyrin levels, and greater textural change on the silicone side (p = 0.04), suggesting increased susceptibility to acneiform eruptions. Patient-reported outcomes and physician global assessments revealed no significant difference in overall aesthetic results between sides.
CONCLUSION: White paraffin ointment provided comparable or superior management of acute post-resurfacing wounds. Silicone-based gel may elevate porphyrins and potentially predispose to acneiform eruptions, warranting further study.
PMID:41195573 | DOI:10.1080/09546634.2025.2583235
