Biomarkers. 2025 Nov 13:1-15. doi: 10.1080/1354750X.2025.2589251. Online ahead of print.
ABSTRACT
BACKGROUND: Several studies have identified that HOTAIR polymorphisms were expressed abnormally in a range of cancers, including breast, gastric, liver, and lung cancers. However, the impact of this gene on colorectal cancer (CRC) remains a topic of debate. To obtain the most accurate results, the association of HOTAIR polymorphisms with CRC risk was analyzed in this meta-analysis (MA).
METHODS: The PubMed, Embase, Cochrane, and Web of Science databases were searched to find the correlation of HOTAIR polymorphisms with CRC up to February 2024. The association of HOTAIR polymorphisms with CRC susceptibility was assessed using odds ratios (ORs) and 95% confidence intervals (CIs).
RESULTS: Five relevant studies were identified in total. In all HOTAIR polymorphism studies involving CRC, it was found that the subgroup analysis by ethnicity revealed that the rs1899663 G > T codominant and dominant models were positively correlated with CRC development in Asian populations and negatively correlated with CRC development in non-Asian populations (Codominant: OR = 0.70, 95% CI = 0.39 – 1.25; D: Dominant: OR = 0.65, 95% CI = 0.28 – 1.53）.
CONCLUSIONS: This MA indicates that HOTAIR polymorphism-the rs1899663 G > T genotype-might have a racially specific impact on CRC risk.
PMID:41231428 | DOI:10.1080/1354750X.2025.2589251
