Clin Oral Investig. 2025 Nov 29;29(12):592. doi: 10.1007/s00784-025-06663-0.
ABSTRACT
OBJECTIVE: To evaluate the effects of concentrated growth factors (CGFs) combined with Bio-Oss bone substitute on the periodontal healing of adjacent teeth following impacted tooth extraction.
METHODS: This single-centre prospective controlled study enrolled 60 patients requiring bilateral impacted mandibular third molar extraction. Patients were randomly allocated to a test group (n = 30; extraction socket filled with CGFs + Bio-Oss and covered with a CGF membrane) or control group (n = 30; natural healing). Primary outcomes included periodontal probing depth (PD) and distal bone height measured by cone beam computed tomography at baseline and 3 and 6 months. Secondary outcomes comprised the visual analogue scale (VAS) pain scores, swelling assessment and dry socket incidence. Statistical analysis was performed using SPSS 26.0, with significance set at P < 0.05.
RESULTS: A total of 60 patients were enrolled in this randomised single-blind clinical trial. The test group showed significantly greater PD reduction (2.41 ± 0.89 vs. 1.52 ± 0.73 mm, P < 0.001) and bone height gain (2.87 ± 1.12 vs. 1.63 ± 0.91 mm, P < 0.001) at 6 months than the control group. The VAS pain scores were significantly lower in the test group at days 3 and 7 (P < 0.001). No cases of dry socket occurred in the test group, compared with three cases (11.1%) in the control group. Multivariate analysis revealed that CGFs + Bio-Oss application was the strongest predictor of bone gain ≥ 2 mm (β = 0.412, P < 0.001).
CONCLUSION: Concentrated growth factors combined with Bio-Oss significantly enhance periodontal healing and bone regeneration at adjacent teeth following impacted tooth extraction while reducing postoperative complications. This combined approach represents a promising strategy for clinical practice.
PMID:41317186 | DOI:10.1007/s00784-025-06663-0
