Eat Weight Disord. 2025 Nov 29;30(1):92. doi: 10.1007/s40519-025-01800-w.
ABSTRACT
OBJECTIVE: Despite several studies assessing the impact of resveratrol on obesity indices, previous meta-analyses show conflicting results. Therefore, we conducted this critical umbrella review of interventional meta-analyses on the effect of resveratrol supplementation on body mass index (BMI), body weight (BW), waist circumference (WC), and body fat.
METHODS: Searches were conducted across multiple databases to identify all relevant meta-analyses up to September 30th, 2025. Reported pooled effect sizes (ESs) and 95% confidence intervals (CIs) were extracted from each included study and synthesized using a random-effects model. Methodological quality was assessed using the AMSTAR 2 tool.
RESULTS: Ultimately, 18 meta-analyses were included, with results showing a small but statistically significant reduction in BW (ES: – 0.18 kg, 95% CI – 0.32 to – 0.03, p = 0.02), BMI (ES: – 0.14 kg/m2, 95% CI – 0.2 to – 0.08, p < 0.001), WC (ES – 0.43 cm, 95% CI – 0.64 to – 0.22, p < 0.001), and body fat (ES: – 0.3 kg, 95% CI – 0.48 to – 0.12, p = 0.001) in the resveratrol group compared to the control group, with subgroup analysis revealing statistical significance only in subgroups with doses > 400 mg/day and study duration ˃ 12 weeks.
CONCLUSION: Our review confirms that resveratrol supplementation reduces BW, BMI, WC, and body fat, particularly on doses > 400 mg/day and interventions lasting ˃12 weeks, with small effect sizes. Based on our findings, resveratrol supplementation could be considered as a complementary therapy in the management of obesity.
PMID:41317227 | DOI:10.1007/s40519-025-01800-w
