PNAS Nexus. 2025 Dec 1;4(12):pgaf312. doi: 10.1093/pnasnexus/pgaf312. eCollection 2025 Dec.
ABSTRACT
Autoimmune mechanisms are associated with both congestive heart failure (CHF) and atrial fibrillation (AF). Optic neuritis (ON) is known to elevate the risk of systemic autoimmune disorders. However, it remains uncertain whether ON serves as a risk factor for CHF and AF. This study aimed to investigate the association between ON and the risk of CHF and AF in a nationwide, population-based cohort. The research utilized data from Korea’s National Health Insurance Service, analyzing 15,587 patients newly diagnosed with ON and 77,935 age- and sex-matched controls from 2010 to 2017. Factors of demographics, medical history, lifestyle, and lab results were considered. CHF and AF incidences were identified through ICD-10 codes and analyzed using Cox regression models adjusted for confounders. During the 4-year follow-up, CHF and AF were diagnosed in 3.39 and 0.86% of participants, respectively. ON patients showed higher risks of CHF [hazard ratio (HR) = 1.341] and AF (HR = 1.215) after adjusting for potential confounders. Notably, stronger associations for CHF risk were found in patients younger than 50 years and those in the lowest income quartile. The findings provide compelling evidence of an independent association between ON and increased risks of CHF and AF, especially in younger individuals, suggesting a role of autoimmune processes in ON under these cardiovascular conditions. The study highlights the need for early cardiac evaluation in ON patients and suggests that timely interventions could improve prognosis. Further research is necessary to understand the pathophysiological links between ON and cardiovascular disorders.
PMID:41334361 | PMC:PMC12665501 | DOI:10.1093/pnasnexus/pgaf312
