J Hum Nutr Diet. 2021 Jul 29. doi: 10.1111/jhn.12936. Online ahead of print.
ABSTRACT
OVERVIEW: This study examined the effect of a herbal supplement containing a Gynostemma pentaphyllum (Gpp) extract (ActivAMP®) on improving body composition in overweight males and females.
METHODS: One-hundred and seventeen men and women aged over 18 completed 16 weeks of daily supplementation with either Gpp or a placebo. Participants underwent dual-energy X-rays to assess body composition (fat mass, lean mass and mass distribution) as well as anthropometric measures (weight, height, hip and waist circumference) and blood tests to assess inflammatory and safety markers.
RESULTS: Following 16 weeks of treatment the Gpp group had a significant reduction in total body weight, BMI, total fat mass and gynoid fat mass compared to the placebo group. Blood measures showed plasma triglyceride, ALT and TNF-α statistically different between groups at week 16. Sub-group analysis of gender for fat distribution showed males in the Gpp group had a significant reduction in visceral fat compared to males in the placebo group and females in the Gpp group had a significant reduction in gynoid fat compared to the placebo group.
CONCLUSIONS: Gpp was capable of altering fat mass and fat distribution in overweight and obese males and females compared to a placebo. This article is protected by copyright. All rights reserved.
PMID:34323337 | DOI:10.1111/jhn.12936
