Exp Brain Res. 2025 Dec 23;244(1):15. doi: 10.1007/s00221-025-07212-7.
ABSTRACT
The aim of this study was to evaluate hand muscle strength, dexterity and hand sensation in individuals with type 2 diabetes with and without peripheral neuropathy. The study was completed with a total of 57 patients with diabetic peripheral neuropathy (DPN+) (n = 31) and without diabetic peripheral neuropathy (DPN-) (n = 26). Semmes-Weinstein Monofilament Test (SWMT) was used for light touch sensation, 128 Hz tuning fork for vibration sensation, esthesiometer for two-point discrimination sensation, Baseline hydraulic hand dynamometer for rough grip strength, Baseline pinch meter for finger pinch strength, and 9-hole peg test (NHPT) for manual dexterity. When light touch sensation was examined in DPN+ and DPN- groups, a significant difference was found between the groups (p < 0.05). When two-point discrimination sense was evaluated between the DPN+ and DPN- groups, it was found to be significant in favor of the DPN+ group in the 1st finger of the right hand and 2nd and 3rd fingers of the left hand (p < 0.05). Rough grip strength values were found to be significantly lower in the DPN+ group in both hands (p < 0.05). In the DPN+ group, left 1st and 2nd finger pinch strength values were found to be statistically significant (p < 0.05). Manual dexterity values were significantly higher in the DPN+ group (p < 0.05). Peripheral sensory nerve involvement in diabetic patients reduces hand grip strength and hand function. Understanding these connections between diabetes, sensation, and muscle strength is important for developing targeted interventions and rehabilitation strategies to help diabetic patients maintain their quality of life.
PMID:41432912 | DOI:10.1007/s00221-025-07212-7
