J Appl Microbiol. 2021 Aug 1. doi: 10.1111/jam.15245. Online ahead of print.
ABSTRACT
AIMS: We evaluated the activity of the preservative chlorphenesin and of four antimicrobial cosmetic multifunctional ingredients against various strains of Gram-negative and Gram-positive human opportunistic pathogens.
METHODS AND RESULTS: Growth kinetics, modeling growth parameters and statistical analyses enabled comparing bacterial behavior in the presence and in the absence of compound. Whatever compound tested (i.e. chlorphenesin, phenylpropanol, hexanediol, ethylhexylglycerin, hydroxyacetophenone), and strain origin (i.e. clinical versus industrial), the growth of 42 strains belonging to Acinetobacter spp., Burkholderia cepacia complex, and Stenotrophomonas maltophilia, was totally inhibited. On the opposite all of the P. aeruginosa strains (n=13) as well as 4 and 6 out of 10 strains of Pluralibacter gergoviae grew in the presence of chlorphenesin and ethylhexylglycerin, respectively. Some P. gergoviae and Staphylococcus hominis strains withstand hydroxyacetophenone. Within a species, the different strains show variable latency phase, growth rate (r), and carrying capacity (K). They can be similar, lower, or higher than those measured in control conditions.
CONCLUSIONS: Data showed differences in the antimicrobial activity of compounds. Upon exposure, strains differed in their behavior between and within species. Whatever species and strains, compound sensitivity could not be related to antibiotic resistance.
SIGNIFICANCE AND IMPACT OF THE STUDY: Most multifunctional ingredients showed significant antimicrobial properties against the wide panel of species and strains evaluated. This will help adjusting preservation strategies in the cosmetic industry.
PMID:34333822 | DOI:10.1111/jam.15245
