Zh Nevrol Psikhiatr Im S S Korsakova. 2026;126(3. Vyp. 2):12-20. doi: 10.17116/jnevro202612603212.
ABSTRACT
OBJECTIVE: To study the features of left ventricle (LV) structural adjustment and comorbidity in patients with chronic cerebral ischemia (CCI) based on gender.
MATERIAL AND METHODS: The study included 316 patients diagnosed with chronic cerebral ischemia with a mean age of 61.9 years (range 36 to 86 years). All patients underwent a general clinical examination, assessment of echocardiography parameters, and measurement of the thickness of the common carotid artery (CCA) intima-media complex (IMC). The patients were divided into two groups based on gender: Group I included males (n=170), and Group II included females (n=146).
RESULTS: In males with CCI, the CCA IMC thickness (1.23±0.14 mm vs 1.16±0.11 mm, p<0.05) and the prevalence of atherosclerotic changes (57.6% vs 34.9%, p<0.05) were significantly higher than in females. Normal LV geometry was reported in 59.4% of males and only in 37.0% of females (p<0.05). The frequency of concentric LV remodeling was 8.8% in males and 6.2% in females. LV hypertrophy (LVH) was detected in 31.8% of males and 56.8% of females (p<0.05). The concentric type of LVH was more common in males (68.5%), whereas the eccentric type prevailed in females (74.7%). A statistically significant correlation of CCA IMC thickness with age (r=0.234), systolic (r=0.209) and diastolic blood pressure (r=0.151), hemoglobin concentration (r=-0.245), end-systolic LV size (r=0.125), end-systolic (r=0.151) and end-diastolic (r=0.135) LV volumes, as well as LV myocardial mass index (r=0.132) in the total sample was found. In the male group, CCA IMC thickness correlated with body mass index (r=0.291) and diastolic blood pressure (r=0.210). In the female group, strong correlations were found with hemoglobin concentration (r=-0.732) and end-systolic LV volume (r=0.176).
CONCLUSION: In patients with CCI, the most common morphofunctional LV changes were concentric LVH in males and eccentric LVH in females.
PMID:41943956 | DOI:10.17116/jnevro202612603212
