Category: Nevin Manimala

Med Sci Monit. 2025 Sep 20;31:e949298. doi: 10.12659/MSM.949298.

ABSTRACT

BACKGROUND Many methods are used to increase the osseointegration of dental implants. This study aimed to evaluate the effect of injectable platelet-rich fibrin (i-PRF) on the osseointegration of dental implants in 20 patients, as measured by resonance frequency analysis. MATERIAL AND METHODS The study included 20 patients, with each patient receiving 2 SLA implants. After preparing the 2 implant sockets in each patient, one socket was randomly selected and irrigated with i-PRF before implant placement, while the other socket was left untreated. Implant stability was evaluated using a frequency analysis device at a 3-month evaluation. RESULTS The initial implant stability quotient (ISQ) values of the implants in the the test group (i-PRF+) averaged 68.875±9.571, increasing to 74.237±8.283 after 3 months. In the control group (i-PRF-), the initial ISQ values averaged 73.275±7.699 and measured 73.662±8.089 after 3 months. The ISQ values of women in the i-PRF+ group were significantly higher than those of men (P=0.004), whereas no statistically significant difference was found between male and female patients in the i-PRF- group (P=0.399). No statistically significant difference was found in ISQ values based on bone density in either the test or control groups (test group, P=0.109; control group, P=0.430). CONCLUSIONS Implants treated with i-PRF demonstrated significantly higher stability values in resonance frequency evaluations compared to untreated implants. Additionally, while i-PRF application resulted in a significantly greater increase in stability in women than in men, bone density did not have an effect on stability.

PMID:40974036 | DOI:10.12659/MSM.949298

Am J Med Genet A. 2025 Sep 19:e64258. doi: 10.1002/ajmg.a.64258. Online ahead of print.

ABSTRACT

Acid sphingomyelinase deficiency (ASMD), or Niemann-Pick disease types A, B, and A/B, is a rare lysosomal storage disorder caused by SMPD1 mutations. Clinical forms range from severe neurovisceral (type A) to chronic visceral (type B), mainly affecting the liver, spleen, and lungs. Until 2022, treatment was limited to supportive care. The approval of olipudase alfa for the non-central nervous system (CNS) manifestations of ASMD marked a major advance, with trials showing improvements in organ volumes and lung function. This meta-analysis evaluates the broader clinical impact of olipudase alfa in ASMD. A systematic search of Cochrane, PubMed, and Embase identified RCTs and cohort studies on olipudase alfa in patients with ASMD. Primary outcomes included mean change in %DLco, %Liver volume, and %Spleen volume; other secondary outcomes were also assessed. Study selection followed PRISMA guidelines, and statistical analyses were conducted using R software. The study was registered in PROSPERO CRD420251032281. Three studies (One RCT) encompassing 46 patients were included. Follow-up duration ranged from 1 to 6.5 years. All patients received olipudase alfa; only one study included a placebo group. Pooled results showed a mean DLco increase of 34.63% (95% CI: 26.09-43.18), a liver volume reduction of -37.76% (95% CI: -49.78 to -25.75), and a spleen volume reduction of -49.46% (95% CI: -57.39 to -41.53) after 2 years. The olipudase alfa demonstrates substantial clinical benefits in ASMD, significantly improving lung function and reducing organomegaly. Further studies are needed to confirm long-term safety and efficacy.

PMID:40974024 | DOI:10.1002/ajmg.a.64258

Aesthet Surg J. 2025 Sep 19:sjaf187. doi: 10.1093/asj/sjaf187. Online ahead of print.

ABSTRACT

BACKGROUND: Labiaplasty improves women’s genital self-image, sexual function, and mental well-being, while enhancing male partners’ sexual satisfaction and overall couple sexual harmony.

OBJECTIVES: This study aims to evaluate the effects of labiaplasty on women’s genital self-perception, sexual function, psychological state and sexual satisfaction levels of male partners in women with physical and functional complaints about labium minus.

METHODS: 97 women and their partners who underwent labiaplasty between January 2021 and June 2024 were included in the study. Beck Depression Inventory (BDI), Female Sexual Function Index (FSFI), Quality of Sexual Experience Scale (QSES), Female Genial Self-Image Scale (FSGIS), Sexual Quality of Life – Female (SQoL-F) questionnaires were applied to women before and after labiaplasty. Male Sexual Health Questionnaire-Ejaculatory Dysfunction (MSHQ-Ejd), Golombok-Rust Sexual Satisfaction Scale (GRISS), New Sexual Satisfaction Scales (NSSS) were applied to male partners. Preoperative and postoperative data were compared with participants who were one year postoperatively.

RESULTS: In female participants, significant improvements were found in genital self-perception, sexual function, sexual pleasure, lubrication, orgasm and overall quality of sexual life, and a statistically significant decrease in depression scores was observed. In male partners, ejaculatory function remained constant, but positive changes were found in general sexual satisfaction, impotence, premature ejaculation and satisfaction levels.

CONCLUSIONS: Labiaplasty operation provides significant gains not only in terms of aesthetics but also psychological and sexual well-being in women, and indirectly positively affects the quality of sexual life of male partners. It is thought that surgical intervention can increase sexual harmony in couple relationship as well as individual satisfaction.

PMID:40974005 | DOI:10.1093/asj/sjaf187

Aust J Rural Health. 2025 Oct;33(5):e70089. doi: 10.1111/ajr.70089.

ABSTRACT

BACKGROUND: Parkinson’s disease (PD) is a common neurodegenerative condition with no known cure. The prevalence of PD and barriers to accessing clinical care increase with distance from major cities. Understanding factors associated with health-related quality of life (HRQoL) in PD has important clinical and public health implications.

METHOD: In a national survey of Australian adults diagnosed with PD, we examined the influence of location on HRQoL and demographics, symptom course and diagnosis, treatment utilisation and preferences, and satisfaction with current services. Final data included 87 respondents from six states in Australia, with 55 identified as living in regional areas and 32 in major cities. Measures also included the Parkinson’s Disease Questionnaire (PDQ-39) and self-reported Hoehn and Yahr scale for disease severity.

RESULTS: Time to obtain a diagnosis was significantly longer for regional respondents than major city counterparts. There were also significant differences in prioritising 10 statements relating to PD. In an overall analysis examining the impact of all the above variables on HRQoL as determined by the PDQ-39, only the Hoehn and Yahr scores explained significant variance; there was no significant difference between regional and metropolitan respondents after accounting for the other variables.

CONCLUSION: Individuals living in regional areas experienced longer delays in obtaining a diagnosis of PD. Both groups highly rated better access to neurologists and the need for better diagnosis as priorities. Location, disease duration and satisfaction with services were not significantly associated with HRQoL.

PMID:40973986 | DOI:10.1111/ajr.70089

Occup Med (Lond). 2025 Aug 1;75(6):341-347. doi: 10.1093/occmed/kqaf023.

ABSTRACT

BACKGROUND: An extensive health and social services reform was implemented in Finland at the beginning of 2023.

AIMS: To describe the working conditions and well-being of persons preparing extensive organizational changes, to compare their results to the reference group, to analyse whether unreasonable workload impacted work recovery, psychosocial distress, work ability and work performance, and to analyse whether the changes in work recovery, psychosocial distress and work ability were associated with a change in work performance.

METHODS: Data were collected by four surveys from reform preparers in 2022 in open cohort settings. Descriptive statistics were used to report the preparers’ situation and in relation to the reference group at the endpoint. Further, covariance and linear regression analyses were performed to study the associations between start and endpoint data (N = 340).

RESULTS: While putting in significant effort, decreasing proportions of preparers experienced leader support, participatory safety and opportunities for innovation. Many preparers had unreasonable workload, a significant proportion working long hours and doing preparation work alongside their main responsibilities. Their situation was notably worse on various work-related indicators compared to the reference group. Unreasonable workload and adverse changes in working conditions decreased the well-being of many preparers, impacting their work performance.

CONCLUSIONS: When preparing for extensive organizational changes, the focus should be on leading preparers’ collaboration and work processes. Leadership should support innovation, foster a positive team climate, ensure participatory safety and provide a reasonable workload to support well-being. Good working conditions are important as they promote better well-being, work ability and performance.

PMID:40973973 | DOI:10.1093/occmed/kqaf023

Occup Med (Lond). 2025 Aug 1;75(6):369-376. doi: 10.1093/occmed/kqaf064.

ABSTRACT

BACKGROUND: The aftermath of the 2008 recession created conditions in which precarious employment may have become more common in the UK. We characterized two distinct periods: high unemployment/lower income (2011-5) and lower unemployment/stagnant income (2015-9).

AIMS: We aimed to describe the prevalence and persistence of these dimensions of precarious employment over two time periods (2011-5 and 2015-9) and investigate the prevalence of precarious employment patterns, poor self-rated health and common mental disorder.

METHODS: We used the UK Longitudinal Household Study to create employment history sequences for three dimensions of precarious employment using two four-wave samples. We applied latent class analysis to sequenced data to identify people persistently exposed to each dimension of precarious employment. We calculated age-sex standardized prevalence of poor self-rated health and common mental disorder by latent class for each precarious employment dimension.

RESULTS: Our analysis included 16 161 (2011-15) and 12 963 (2015-19) individuals. We found a latent class representing persistent exposure to each of the three precarity dimensions, but little overlap between these classes. Latent classes were very similar for both study periods. Prevalence of poor self-rated health and common mental disorder increased for most latent classes between 2011-15 and 2015-19. Employment discontinuity had the highest prevalence out of the precariously employed latent classes for both outcomes.

CONCLUSIONS: A minority of workers in the UK were in a state of chronic precarity, which did not change substantially between the two time periods. Experiencing persistent employment discontinuity was the dimension of precarity with the highest levels of poor health.

PMID:40973972 | DOI:10.1093/occmed/kqaf064

BMC Gastroenterol. 2025 Sep 19;25(1):642. doi: 10.1186/s12876-025-04235-w.

ABSTRACT

BACKGROUND: Pakistan has one of the highest rates of chronic liver disease (CLD) burden in the world. Poor and underserved patients of CLD in the country may suffer from limited health-seeking behaviors, but there is not much research in this area. The aim of this study is to better plan support for CLD patients by identifying: (i) Health-seeking behaviors (HSB) according to patient-type; and (ii) the relationship of HSB with patient socio-demographic variables and independent study domains.

METHODS: We conducted a cross-sectional study. Data was collected over a four-month period from May 2022 to August 2022. A total of 850 patients visiting the Pakistan Kidney and Liver Institute and Research Centre were part of the study. We used correlation tests and multivariate logistic regression to investigate the relationship between the health-seeking behavior and the independent study domains (economic stability, health literacy, social support, experiencing grief, mental health, healthcare service quality, and coping strategies).

RESULTS: Main results suggest that patients with hepatocellular carcinoma, non-viral liver disease, and cirrhosis have less HSB, compared to patient with chronic viral hepatitis. Multivariate logistic regression results reveal that the following groups have lower odds for health-seeking behavior: (i) illiterate people; (ii) those living in rented homes; (iii) those belonging to nuclear families; and (iv) those with low monthly household income. The following study domains also show lower odds for HSB: (i) health illiteracy; (ii) low health service quality; (iii) low ability to use coping strategies; (iv) grief; (v) lack of social support; (vi) mental health challenges; and (vii) economic instability.

CONCLUSIONS: Our study highlights that the majority of CLD patients are poor, illiterate, or semi-literate and in urgent need of holistic care with respect to health literacy, mental health counseling, financial help, and improved support from provider and families. This is only possible through the integration of social policy officers and social workers in the tertiary health sector of the country.

PMID:40973962 | DOI:10.1186/s12876-025-04235-w

Oral Maxillofac Surg. 2025 Sep 20;29(1):158. doi: 10.1007/s10006-025-01459-8.

ABSTRACT

PURPOSE: This study aimed to assess the clinical and radiographic outcomes of transcrestal maxillary sinus lifting using Densah burs in combination with activated plasma albumin gel (APAG) during simultaneous implant placement in cases with severely limited residual bone height (3-5 mm).

METHODS: A total of six patients with missing posterior maxillary teeth and insufficient alveolar bone height were treated using the osseodensification technique with Densah burs and APAG. CBCT scans were obtained preoperatively and six months postoperatively to evaluate changes in bone height and peri-implant bone density. Bone density was estimated using CBCT gray values derived from OnDemand 3D software, recognizing that these values provide relative rather than absolute measurements and are subject to inherent limitations.

RESULTS: No post-operative complications were recorded, and the sinus membrane remained intact in all cases. After six months, a statistically significant bone height gain was observed (mean 5.28 ± 0.70 mm; p < 0.001), along with a significant increase in bone density (mean difference 255.15 ± 95.69 HU; p < 0.001). Implant stability showed no statistically significant difference between primary and secondary ISQ values (mean difference 1.17 ± 4.31; p = 0.54).

CONCLUSION: The combined use of Densah burs and activated plasma albumin gel for transcrestal sinus lifting appears to be a safe and minimally invasive technique, promoting substantial bone height gain and improved peri-implant bone density. The bioactive plasma gel played a key role in effective sinus membrane elevation and vertical bone augmentation.

TRIAL REGISTRATION NUMBER: This trial was retrospectively registered on ClinicalTrials.gov (ID: NCT06360263) in July 2023.

PMID:40973834 | DOI:10.1007/s10006-025-01459-8

Nat Metab. 2025 Sep 19. doi: 10.1038/s42255-025-01371-1. Online ahead of print.

ABSTRACT

A systematic characterization of metabolic profiles in human health and disease enhances precision medicine. Here we present a comprehensive human metabolome-phenome atlas, using data from 274,241 UK Biobank participants with nuclear magnetic resonance metabolic measures. This atlas links 313 plasma metabolites to 1,386 diseases and 3,142 traits, with participants being prospectively followed for a median of 14.9 years. This atlas uncovered 52,836 metabolite-disease and 73,639 metabolite-trait associations, where the ratio of cholesterol to total lipids in large low-density lipoprotein percentage was found as the metabolite associated with the highest number (n = 526) of diseases. In addition, we found that more than half (57.5%) of metabolites showed statistical variations from healthy individuals over a decade before disease onset. Combined with demographics, the machine-learning-based metabolic risk score signified the top 30 (around 10%) metabolites as biomarkers, yielding favourable classification performance (area under the curve > 0.8) for 94 prevalent and 81 incident diseases. Finally, Mendelian randomization analyses provided support for causal relationships of 454 metabolite-disease pairs, among which 402 exhibited shared genetic determinants. Additional insights can be gleaned via an accessible interactive resource ( https://metabolome-phenome-atlas.com/ ).

PMID:40973818 | DOI:10.1038/s42255-025-01371-1

Mol Psychiatry. 2025 Sep 19. doi: 10.1038/s41380-025-03235-2. Online ahead of print.

ABSTRACT

Posttraumatic stress disorder (PTSD) is persistent over time, thus identifying risk factors for chronic PTSD is crucial for clinical research. Trauma exposure severity and polygenic liability are two established predictors of PTSD onset and severity, but their contributions to the long-term course of PTSD remain largely unknown. In this prospective longitudinal cohort study, we tested whether severity of trauma exposure and polygenic risk for symptoms of PTSD independently predict long-term trajectories of PTSD symptoms. Data included 49,402 observations, spanning July 2002 to December 2022, from n = 5687 World Trade Center responders who had predominately European ancestry (baseline mean age = 37.74, SD = 8.19, range = 16-75; 92.89% male). First, the best-fitting model of 20-year PTSD trajectories was determined. Next, a polygenic risk score and a sum score of traumatic exposures were included as predictors of individual differences in intercepts (initial levels) and slopes (rates of change), adjusting for demographic covariates. The polygenic risk score significantly predicted rates of change in PTSD symptoms, independent of the intercept, such that higher polygenic risk was associated with more rapid increases in the years after trauma and a steeper arch-shaped trajectory. Exposure severity predicted initial levels and rates of change in symptoms, with more pronounced effects on initial levels. These findings indicate that polygenic liability and exposure severity predict the long-term prognosis of PTSD and have the potential to inform future clinical studies in trauma-exposed populations.

PMID:40973784 | DOI:10.1038/s41380-025-03235-2