Category: Nevin Manimala

J Exp Child Psychol. 2021 May 12;209:105166. doi: 10.1016/j.jecp.2021.105166. Online ahead of print.

ABSTRACT

Difficulties in processing humor have been associated with individuals with autism. The current study investigated whether humor comprehension and appreciation could be augmented in children with autism by providing contextual support suggesting that humor was to be expected. A verbally presented riddle task was used in which participants were assessed for their subjective ratings and comprehension of the materials. They were also filmed to record any smiling or laughing. Both riddles and control stimuli were presented with supporting verbal context and also without it. The results showed that (a) the greater subjective appreciation of riddles than of control stimuli was dependent on the provision of context for the participants with autism and that (b) context statistically equated these ratings of riddles between participants with autism and matched typically developing controls. However, context had no effect on comprehension or affective response. The results of the current study demonstrate that children with autism are, even in the most conservative interpretation, able to use verbal context to recognize verbal humor. This lays the foundation of possible interventions based on training sensitivity to context.

PMID:33991842 | DOI:10.1016/j.jecp.2021.105166

Comput Biol Med. 2021 May 7;134:104430. doi: 10.1016/j.compbiomed.2021.104430. Online ahead of print.

ABSTRACT

Early detection of sepsis can facilitate early clinical intervention with effective treatment and may reduce sepsis mortality rates. In view of this, machine learning-based automated diagnosis of sepsis using easily recordable physiological data can be more promising as compared to the gold standard rule-based clinical criteria in current practice. This study aims to develop such a machine learning framework that demonstrates the quantification of heterogeneity within the tabular electronic health records (EHR) data of clinical covariates to capture both linear relationships and nonlinear correlation for the early prediction of sepsis. Here, the statistics of pairwise association for each hour-covariate pair within the EHR data for every 6-hours window-duration with selected 24 covariates is described using pointwise mutual information (PMI) matrix. This matrix gives the heterogeneity of data as a two-dimensional map. Such matrices are fused horizontally along the z-axis as vertical slices in the xy plane to form a 3-way tensor for each record with the corresponding Length of Stay (L). Tensor factorization of such fused tensor for every record is performed using Tucker decomposition, and only the core tensors are retained later, excluding the 3 unitary matrices to provide the latent feature set for the prediction of sepsis onset. A five-fold cross-validation scheme is employed wherein the obtained 120 latent features from the reshaped core tensor, are fed to Light Gradient Boosting Machine Learning models (LightGBM) for binary classification, further alleviating the involved class imbalance. The machine-learning framework is designed via Bayesian optimization, yielding an average normalized utility score of 0.4519 as defined by challenge organizers and area under the receiver operating characteristic curve (AUROC) of 0.8621 on publicly available PhysioNet/Computing in Cardiology Challenge 2019 training data. The proposed tensor decomposition of 3-way fused tensor formulated using PMI matrices leverages higher-order temporal interactions between the pairwise associations among the clinical values for early prediction of sepsis. This is validated with improved risk prediction power for every hour of admission to the ICU in terms of utility score, AUROC, and F1 score. The results obtained show a significant improvement particularly in terms of utility score of ~1.5-2% under a 5-fold cross-validation scheme on entire training data as compared to a top entrant research study that participated in the challenge.

PMID:33991856 | DOI:10.1016/j.compbiomed.2021.104430

Soc Sci Med. 2021 May 7;279:113959. doi: 10.1016/j.socscimed.2021.113959. Online ahead of print.

ABSTRACT

Result Based Financing (RBF) has been implemented in health systems across low and middle-income countries (LMICs), with the objective of improving population health. Most evaluations of RBF schemes have focused on average programme effects for incentivised services. There is limited evidence on the potential effect of RBF on health outcomes, as well as on the heterogeneous effects across socio-economic groups and time periods. This study analyses the effect of Zimbabwe’s national RBF scheme on neonatal, infant and under five mortality, using Demographic and Health Survey data from 2005, 2010 and 2015. We use a difference in differences design, which exploits the staggered roll-out of the scheme across 60 districts. We examine average programme effects and perform sub-group analyses to assess differences between socio-economic groups. We find that RBF reduced under-five mortality by two percentage points overall, but that this decrease was only significant for children of mothers with above median wealth (2.7 percentage points) and education (2.1 percentage points). RBF increased institutional delivery by seven percentage points – with a statistically significant effect for poorer socio-economic groups and least educated. We also find that RBF reduced c-section rates by three percentage points. We find no detectable effect of RBF on other incentivised services. When considering programme effects over time, we find that effects were only observed during the second phase of the programme (March 2012) with the exception of c-sections, which only reduced in the longer term. Further research is needed to examine whether these findings can be generalised to other settings.

PMID:33991792 | DOI:10.1016/j.socscimed.2021.113959

Acta Psychol (Amst). 2021 May 12;217:103330. doi: 10.1016/j.actpsy.2021.103330. Online ahead of print.

ABSTRACT

Merely observing how another person responds to a stimulus results in incidental stimulus-response (SR) bindings in memory. These observationally acquired SR bindings can be retrieved on a later occasion. Retrieval will bias current behavioral response tendencies towards re-execution of the observed response. Previous demonstrations of this effect endorsed a dyadic interaction paradigm in which two co-actors respond in alternating fashion. The present paper investigates a video-based version of the observational SR binding task in which videotaped responses are observed on screen. Whereas findings from the dyadic paradigm indicate that retrieval of observationally acquired SR bindings is modulated by social relevance, the video-based paradigm is not influenced by social moderators. Data of four experiments show that manipulations of visual perspective, natural and artificial group membership had no modulatory effect on retrieval of observationally acquired SR bindings in the video-based paradigm. The absence of any socially modulated effect in the video-based paradigm is supported by Bayesian statistics in favor of the null hypothesis. Data from a fifth experiment suggests that observational SR binding and retrieval effects in the video-based paradigm reflect the influence of spatial attention allocated towards response keys of observed responses. Implications for the suitability of both paradigms to study observational learning and joint action phenomena are discussed.

PMID:33991796 | DOI:10.1016/j.actpsy.2021.103330

Public Health. 2021 May 12;194:252-259. doi: 10.1016/j.puhe.2021.02.027. Online ahead of print.

ABSTRACT

OBJECTIVES: This project aimed to assess the effectiveness of a community-based theatre intervention to improve attitudes towards and increase knowledge about LGBTQ+ communities among audiences in Mumbai, India.

STUDY DESIGN: This study was a program evaluation using pre- and post-show surveys that incorporated an adapted version of The Riddle Scale: Attitudes Towards Difference and questions assessing self-reported knowledge about LGBTQ+-related issues to assess changes in attitudes and knowledge after viewing the theatre intervention.

METHODS: An original 90-min devised play was created by a company of Indian, American, and Canadian theatre artists using Participatory Action Research methods and was designed to bring audiences to a deeper understanding of LGBTQ+ identity. The show was performed four times in Mumbai, India, and pre-/post-show surveys were collected at each performance. Audience survey responses were analysed using parametric and non-parametric descriptive statistics as appropriate, and Likert scale questions were compared using Wilcoxon Signed Rank for non-parametric data.

RESULTS: A total 184 surveys were completed across four performances between March 7 and 14, 2020. Significant increases in audiences’ self-reported knowledge of LGBTQ+ identity, impacts of discrimination, and struggles faced by LGBTQ+ communities were reported after viewing the show. Furthermore, attitudes towards LGBTQ+ rights, understanding of the challenges of being LGBTQ+ in India, and recognition of the contributions LGBTQ+ individuals make to society improved significantly among our audiences after test. The play further fostered increased acceptance of prosocial behaviours towards LGBTQ+ individuals with higher percentages of audiences recognizing the importance of standing up to homophobia and anti-gay attitudes. While these observations were seen across audiences, they were particularly pronounced among cisgender heterosexual men and audiences ages 18-24.

CONCLUSION: Community-based theatre intervention is highly acceptable and effective as a medium for informing positive attitudes, improving knowledge, and promoting acceptance of and solidarity towards LGBTQ+ communities among young adult heterosexual audiences.

PMID:33991810 | DOI:10.1016/j.puhe.2021.02.027

Aten Primaria. 2021 May 12;53(8):102084. doi: 10.1016/j.aprim.2021.102084. Online ahead of print.

ABSTRACT

OBJECTIVE: To determine the unexpected return rate to the Primary Care Emergency Service of elderly patients over 65 years old within the following 72h of a previous visit, as well as to determine the clinical and assistance requirements of these patients.

PROCEDURE: Retrospective and observational epidemiologic study.

LOCATION: Cotolino’s Primary Care Emergency Service in Cantabria, Spain.

PARTICIPANTS: 1940 elderly patients over 65 years old were included. These patients returned to the Primary Care Emergency Service in 2016.

MAIN DATA FOR THE STUDY: The dependent variable was the return rate to the Primary Care Emergency Service. The independent variables were socio-demographic characteristics, health details and medical assistance information. All data was collected from the Primary Care Emergency Service Management Office database. All variables were analysed applying Pearson’s chi-squared test and Fisher’s exact test, with statistical significance P≤.05.

RESULTS: The rate of unexpected return was 2.3%. The average age was 77.4 years old (standard deviation (SD): 8.4), of which the 37.6% were male. The most frequent range of age was from 75 to 84 years old, with males being the predominant group. A history of polymedication was detected in 54.4% of the cases, as well as a medium cardiovascular risk within this group. Nursing professionals attended the 42.2% of these return cases (P<.001). Patients with dysnea (P=.015), scheduled care or scheduled injection returned with a higher frequency (P<.001). It was as well noticed a higher frequency of return for subsequent attention during the months of December and January (P<.001).

CONCLUSIONS: The rate of unexpected return is low. The main causes why elderly patients returned to the service requiring urgent assistance were issues categorised as unspecific general health indicators and/or respiratory system illnesses. Our proposal is to develop specific protocols combining the work from both Geriatrics and Gerontology professionals, in order to improve the support to this group of population at every Primary Care Emergency Service.

PMID:33991761 | DOI:10.1016/j.aprim.2021.102084

Ann Diagn Pathol. 2021 Apr 19;53:151744. doi: 10.1016/j.anndiagpath.2021.151744. Online ahead of print.

ABSTRACT

OBJECTIVES: Assess the pathologic changes in the lungs of COVID-19 decedents and correlate these changes with demographic data, clinical course, therapies, and duration of illness.

METHODS: Lungs of 12 consecutive COVID-19 decedents consented for autopsy were evaluated for gross and histopathologic abnormalities. A complete Ghon “en block” dissection was performed on all cases; lung weights and gross characteristics recorded. Immunohistochemical studies were performed to characterize lymphocytic infiltrates and to assess SARS-CoV-2 capsid protein.

RESULTS: Two distinct patterns of pulmonary involvement were identified. Three of 12 cases demonstrated a predominance of acute alveolar damage (DAD) while 9 of 12 cases demonstrated a marked increase in intra-alveolar macrophages in a fashion resembling desquamative interstitial pneumonia or macrophage activation syndrome (DIP/MAS). Two patterns were correlated solely with a statistically significant difference in the duration of illness. The group exhibiting DAD had duration of illness of 5.7 days while the group with DIP/MAS had duration of illness of 21.5 days (t-test p = 0.014).

CONCLUSIONS: The pulmonary pathology of COVID-19 patients demonstrates a biphasic pattern, an acute phase demonstrating DAD changes while the patients with a more prolonged course exhibit a different pattern that resembles DIP/MAS-like pattern. The potential mechanisms and clinical significance are discussed.

PMID:33991784 | DOI:10.1016/j.anndiagpath.2021.151744

Vet Parasitol. 2021 May 7;294:109444. doi: 10.1016/j.vetpar.2021.109444. Online ahead of print.

ABSTRACT

Lice are common production-limiting ectoparasites affecting livestock. Up-to-date data on their prevalence and spatial distribution on farms in Great Britain is important given that prevalence is believed to be increasing as a result of insecticide resistance. Here the prevalence of farms reporting lice, and factors associated with louse presence, were assessed using a retrospective questionnaire. For sheep and cattle farms, 16.1 % and 15.8 % reported lice on their livestock, respectively. Beef farms were more likely to report lice than dairy farms, with a prevalence of 18.0 % and 7.8 %, respectively. For sheep farms, prevalence was highest in Wales (27.7 %) and Scotland (22.4 %). For cattle farms, prevalence was highest in Scotland (27.6 %), Wales (18.5 %) and SW England (18.5 %). For sheep farms, statistical hotspot clusters were identified in Wales, NW England and SW Scotland, with prevalence in these areas ranging from 30.7 to 40.0%. For cattle farms clustering of cases was less evident. Multivariable analysis showed that significant factors associated with lice on sheep farms were larger flock sizes and geographic location (Scotland or Wales). For beef cattle farms, significant associated factors were larger herd sizes and upland grazing. More than 90 % of farms that reported lice, also reported treating for lice.

PMID:33991726 | DOI:10.1016/j.vetpar.2021.109444

Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 May 12:S2451-9022(21)00140-3. doi: 10.1016/j.bpsc.2021.05.001. Online ahead of print.

ABSTRACT

BACKGROUND: Tourette syndrome (TS) is a neurodevelopmental disorder involving chronic motor and phonic tics. Most individuals with Tourette syndrome can suppress their tics for at least a short period of time. Yet, the brain correlates of tic suppression are still poorly understood.

METHODS: In the current study, high-density electroencephalography (EEG) was recorded during a resting-state and a tic suppression session in 72 children with TS. Functional connectivity between cortical regions was assessed in the alpha band (8-13 Hz) using an EEG source connectivity method. Graph theory and network-based statistics were used to assess the global network topology and to identify brain regions showing increased connectivity during tic suppression.

RESULTS: Graph theoretical analyses revealed distinctive global network topology during tic suppression, relative to rest. Using network-based statistics, we found a subnetwork of increased connectivity during tic suppression (p < .001). That subnetwork encompassed many cortical areas, including the right superior frontal gyrus and the left precuneus, which are involved in the default mode network. We also found a condition by age interaction, suggesting age-mediated increases in connectivity during tic suppression.

CONCLUSIONS: These results suggest that children with TS suppress their tics through a brain circuit involving distributed cortical regions, many of which are part of the default mode network. Brain connectivity during tic suppression also increases as youths with TS mature. These results highlight a mechanism by which children with TS may control their tics, which could be relevant for future treatment studies.

PMID:33991741 | DOI:10.1016/j.bpsc.2021.05.001

J Neuroimmunol. 2021 Apr 30;356:577600. doi: 10.1016/j.jneuroim.2021.577600. Online ahead of print.

ABSTRACT

Multiple Sclerosis (MS) is caused by a still unknown interplay between genetic and environmental factors. Epigenetics, including DNA methylation, represents a model for environmental factors to influence MS risk. Twenty-six affected and 26 unaffected relatives from 8 MS multiplex families were analysed in a multicentric Italian study using MeDIP-Seq, followed by technical validation and biological replication in two additional families of differentially methylated regions (DMRs) using SeqCap Epi Choice Enrichment kit (Roche®). Associations from MeDIP-Seq across families were combined with aggregation statistics, yielding 162 DMRs at FDR ≤ 0.1. Technical validation and biological replication led to 2 hypo-methylated regions, which point to NTM and BAI3 genes, and to 2 hyper-methylated regions in PIK3R1 and CAPN13. These 4 novel regions contain genes of potential interest that need to be tested in larger cohorts of patients.

PMID:33991750 | DOI:10.1016/j.jneuroim.2021.577600