Category: Nevin Manimala

Medicine (Baltimore). 2025 Apr 11;104(15):e41918. doi: 10.1097/MD.0000000000041918.

ABSTRACT

BACKGROUND: There is a close relationship between asthma and obstructive sleep apnea (OSA), and the mechanisms of these 2 diseases are overlapped. However, the relationship between OSA and allergic asthma remains to be analyzed through systematic review and meta-analysis.

METHODS: A systematic search was conducted using Scopus, PubMed, ISI, Google Scholar, and Cochrane Library by utilizing the keywords Allergic asthma, Obstructive sleep apnea, and OSA. Hazard ratio, odds ratio (OR), and risk ratio with 95% confidence interval, fixed and Mantel-Haenszel methods were calculated. Statistical software Stata was used for the evaluation of this meta-analysis.

RESULTS: Finally, 19 articles were included in this study. The prevalence of OSA in allergic asthma patients was 35.25% (19.92%, 50.57%), which was statistically significant, and pooled analysis of ORs observed in individual studies showed that the odds of OSA prevalence were 2.24 (1.32, 3.12) (P < 0.001). Also, the prevalence of OSA risk in allergic asthma patients was 30.08% (19.73%, 40.43%), which was statistically significant, and pooled analysis of ORs observed in individual studies showed that the odds of OSA risk were 3.46 (2.96, 4.94) (P < 0.001).

CONCLUSION: The present meta-analysis showed that the prevalence of OSA as well as the OSA risk in patients with asthma were significantly higher compared with healthy people.

PMID:40228283 | DOI:10.1097/MD.0000000000041918

Medicine (Baltimore). 2025 Apr 11;104(15):e42135. doi: 10.1097/MD.0000000000042135.

ABSTRACT

Artificial intelligence (AI) and the introduction of Large Language Model (LLM) chatbots have become a common source of patient inquiry in healthcare. The quality and readability of AI-generated patient education materials (PEM) is the subject of many studies across multiple medical topics. Most demonstrate poor readability and acceptable quality. However, an area yet to be investigated is chemotherapy-induced cardiotoxicity. This study seeks to assess the quality and readability of chatbot created PEM relative to chemotherapy-induced cardiotoxicity. We conducted an observational cross-sectional study in August 2024 by asking 10 questions to 4 chatbots: ChatGPT, Microsoft Copilot (Copilot), Google Gemini (Gemini), and Meta AI (Meta). The generated material was assessed for readability using 7 tools: Flesch Reading Ease Score (FRES), Flesch-Kincaid Grade Level (FKGL), Gunning Fog Index (GFI), Coleman-Liau Index (CLI), Simple Measure of Gobbledygook (SMOG) Index, Automated Readability Index (ARI), and FORCAST Grade Level. Quality was assessed using modified versions of 2 validated tools: the Patient Education Materials Assessment Tool (PEMAT), which outputs a 0% to 100% score, and DISCERN, a 1 (unsatisfactory) to 5 (highly satisfactory) scoring system. Descriptive statistics were used to evaluate performance and compare chatbots amongst each other. Mean reading grade level (RGL) across all chatbots was 13.7. Calculated RGLs for ChatGPT, Copilot, Gemini and Meta were 14.2, 14.0, 12.5, 14.2, respectively. Mean DISCERN scores across the chatbots was 4.2. DISCERN scores for ChatGPT, Copilot, Gemini, and Meta were 4.2, 4.3, 4.2, and 3.9, respectively. Median PEMAT scores for understandability and actionability were 91.7% and 75%, respectively. Understandability and actionability scores for ChatGPT, Copilot, Gemini, and Meta were 100% and 75%, 91.7% and 75%, 90.9% and 75%, and 91.7% and 50%, respectively. AI chatbots produce high quality PEM with poor readability. We do not discourage using chatbots to create PEM but recommend cautioning patients about their readability concerns. AI chatbots are not an alternative to a healthcare provider. Furthermore, there is no consensus on which chatbots create the highest quality PEM. Future studies are needed to assess the effectiveness of AI chatbots in providing PEM to patients and how the capabilities of AI chatbots are changing over time.

PMID:40228277 | DOI:10.1097/MD.0000000000042135

Medicine (Baltimore). 2025 Apr 11;104(15):e42134. doi: 10.1097/MD.0000000000042134.

ABSTRACT

The high readmission rate of patients with chronic heart failure (HF) can cause waste of medical resources and economic losses. Establishing an effective HF readmission model can effectively alleviate medical pressure and improve the quality of treatment. In this study, we conducted a comprehensive analysis of clinical and laboratory data from 248 patients with chronic HF who received treatment at our medical center between January 2021 to January 2022. We also measured soluble CD40 ligand (sCD40L) levels to determine their association with readmission due to HF during follow-up. To analyze the data, we employed various statistical methods including one-way ANOVA, correlation analysis, univariate COX regression, and Least Absolute Shrinkage and Selection Operator COX regression. Using these techniques, we organized the data and constructed a predictive model that was both trained and validated. We developed a nomogram to assess the likelihood of readmission within 180 days for patients with chronic HF. Our findings revealed that monocytes, creatinine, sCD40L, and hypertension history were all independent risk factors for 180-day HF readmissions. Additionally, our model’s AUC was 0.731 in the training dataset and 0.704 in the validation dataset. This study provides new insights for predicting readmission within 180 days for patients with chronic HF. And sCD40L is an important predictive indicator for readmission of HF patients within 180 days, and clinical doctors can develop appropriate treatment plans based on sCD40L.

PMID:40228270 | DOI:10.1097/MD.0000000000042134

Medicine (Baltimore). 2025 Apr 11;104(15):e42060. doi: 10.1097/MD.0000000000042060.

ABSTRACT

BACKGROUND: Open reduction and percutaneous pinning (ORPP) is commonly regarded as the primary treatment option for serious displaced lateral condyle fractures of the humerus (LCFs) in children. However, some authors have suggested that closed reduction and percutaneous pinning (CRPP) may be an appropriate method for treating LCFs. This meta-analysis aims to compare the outcomes of these 2 fixation techniques.

METHODS: Our study conducted a search of the Pubmed, Embase, and Cochrane Library databases for published research up to October 1, 2022. Our analysis comprehensively compared the operation failure rate, elbow function, and complication rate between CRPP and ORPP. This study was registered with PROSPERO (CRD42022379655).

RESULTS: Our analysis included 6 non-randomized controlled trials and 532 patients. We used the Newcastle Ottawa Scale to assess the bias risk of these studies, with scores ranging from 6 to 9. The results indicate that both CRPP and ORPP yielded satisfactory elbow function outcomes (OR = 0.35, 95% CI = 0.07-1.88, P = .22). However, CRPP had a significant rate of operative failure (17.65%, OR = 21.77, 95% CI = 3.98-119.08, P = .0004) but a lower likelihood of unsightly scars (OR = 0.06, 95% CI = 0.01-0.31, P = .008). The failure rate of surgery is 0% in ORPP. There were no significant differences found in total infection (OR = 0.46, 95% CI = 0.21-1.01, P = .05), avascular necrosis (OR = 0.84, 95% CI = 0.09-7.79, P = .88), delayed union (OR = 1.49, 95% CI = 0.06-37.35, P = .81), or surgical time (MD = 4.46, 95% CI = -25.92 to 34.84, P = .77).

CONCLUSIONS: In comparison to ORPP, CRPP may result in a higher rate of operative failure but has been found to significantly reduce the occurrence of unsightly scars. Both CRPP and ORPP showed similar levels of postoperative functional satisfaction, with no statistical difference in other complications. Our research suggests that qualified closed reduction is a viable option for doctors to treat LCF.

LEVELS OF EVIDENCE: IV.

PMID:40228269 | DOI:10.1097/MD.0000000000042060

Medicine (Baltimore). 2025 Apr 11;104(15):e42105. doi: 10.1097/MD.0000000000042105.

ABSTRACT

In our study, we aimed to investigate the relationship between anti-müllerian hormone (AMH) and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) score, which are known to be increased in patients with polycystic ovary syndrome (PCOS), and morning blood pressure surge (MBPS), and whether these measurements are a marker for early cardiovascular disease risk in patients with PCOS. Forty patients aged between 18 and 65 years with hypertension (HT) and PCOS, 40 patients with HT but without PCOS, and 40 people representing the healthy control group were included in our prospective, cross-sectional study. All patients underwent ambulatory blood pressure measurement for 24 hours and MBPS was calculated. The study groups were divided into 3 groups as healthy control group (group 1), patient group with HT without PCOS (group 2), and patient group with HT and PCOS (group 3). MBPS was found to be statistically significantly higher in group 3. In linear regression analysis, AMH and HOMA-IR levels were found to be independently associated with MBPS. In patients with PCOS, AMH, and HOMA-IR levels were significantly higher in the group with MBPS > 25 mm Hg. Early diagnosis and treatment of PCOS and accompanying comorbidities can halt the progression of cardiac disorders and reduce cardiovascular mortality and morbidity. AMH level, HOMA-IR score, and MBPS measurement can be used in early detection and prediction of cardiovascular disease in PCOS patients.

PMID:40228266 | DOI:10.1097/MD.0000000000042105

Medicine (Baltimore). 2025 Apr 11;104(15):e41692. doi: 10.1097/MD.0000000000041692.

ABSTRACT

BACKGROUND: To evaluate the effect of laparoscopic procedures integrated with traditional Chinese medicine (TCM), specifically aimed at enhancing blood flow and alleviating blood stasis, on oxidative stress levels in individuals with endometriosis-induced infertility.

METHODS: We performed a systematic quantitative review to evaluate the effects of laparoscopic surgery combined with TCM on oxidative stress in endometriosis-related infertility by enhancing blood circulation and resolving stasis. A literature search of 9 major databases was performed. Meta-analysis was performed using Review Manager version 5.4 (R Foundation for Statistical Computing, Vienna, Austria) and Stata Release 16.0 (StataCorp LLC, College Station, TX). This systematic review was registered with the International Prospective Register of Systematic Reviews (i.e., “PROSPERO”) (registration number: CRD42024526800).

RESULTS: Thirteen trials comprising 1084 participants were included. Laparoscopy combined with TCM for promoting blood circulation and removing blood stasis significantly reduced the levels of 8-isoprostane prostaglandin F2α (mean difference [MD] -29.57 [95% confidence interval (CI) -32.65 to -26.49]; P < .001), regulated on activation, normal T cell expressed and secreted (MD -231.83 [95% CI -341.33 to -122.32]; P < .001), reactive oxygen species (MD -0.92; [95% CI -1.12 to -0.73]; P < .001), monocyte chemoattractant protein-1 (MD -31.23 [95% CI -42.70 to -19.77]; P < .001), and increased glutathione peroxidase (MD 31.45 [95% CI 26.04 to 36.87]; P < .001), vitamin E (MD 4.86 [95% CI 3.77 to 5.94]; P < .001), superoxide dismutase (standardized MD 0.92 [95% CI 0.41 to 1.42]; P < .001).

CONCLUSION: Compared with laparoscopic surgery alone, the combination of TCM for promoting blood circulation and removing blood stasis demonstrated the potential to ameliorate oxidative stress in patients with endometriosis-induced infertility. However, further large-scale clinical trials are required to confirm these findings.

PMID:40228263 | DOI:10.1097/MD.0000000000041692

Medicine (Baltimore). 2025 Apr 11;104(15):e42073. doi: 10.1097/MD.0000000000042073.

ABSTRACT

Anxiety is common in emergency department (ED) patients, affecting physiological stability, treatment adherence, and clinical outcomes. Standardized quality care models may alleviate these effects, but further validation is needed. This study evaluates the impact of a standardized quality care model on anxiety, physiological parameters, and quality of life in ED patients. This retrospective cohort study included 205 ED patients treated between January 2021 and December 2023, selected using consecutive sampling. Patients were categorized into the standardized quality care group (n = 95) or the routine care group (n = 110) based on prior nursing care. Anxiety and depression were assessed using SAS, HAMA, GAD-7, and self-depression scale (SDS), and psychological distress with SCL-90. Quality of life was measured using social functioning (SF)-36v2, while physiological indicators (heart rate, blood pressure, oxygen saturation), patient satisfaction, and medical compliance were recorded. Statistical analyses were conducted using SPSS 26.0, with independent sample t-tests or Mann-Whitney U tests for continuous variables and chi-square (χ²) tests for categorical variables (P < .05 considered significant). The standardized care group had significantly lower anxiety (SAS, HAMA, GAD-7) and depression (SDS) scores than the routine care group (P < .05). Moderate to severe psychological distress (SCL-90) was also lower (P = .015). Physiological indicators, including heart rate (P = .012), systolic blood pressure (P = .03), diastolic blood pressure (P = .03), and oxygen saturation (P = .03), improved significantly. At the 1-month follow-up, SF-36v2 scores, including physical component summary and mental component summary, were significantly higher in the standardized care group (P < .05). Patient satisfaction (χ² = 13.28, P = .004) and medical compliance (χ² = 6.01, P = .049) were also improved. The standardized quality care model effectively reduces anxiety and depression, enhances physiological stability, and improves quality of life, patient satisfaction, and treatment adherence in ED patients. These findings support integrating structured nursing interventions into ED care. Larger prospective studies are needed to validate long-term benefits and explore technology-driven enhancements.

PMID:40228261 | DOI:10.1097/MD.0000000000042073

Medicine (Baltimore). 2025 Apr 11;104(15):e42163. doi: 10.1097/MD.0000000000042163.

ABSTRACT

Pneumonia and other lower respiratory tract diseases rank as the fourth leading cause of death worldwide. The objective of this study was to examine pneumonia hospitalization patterns, and trends in total pneumonia hospitalization stratified by age group, by type of hospitalization, and by age group in Australia, England, Wales. This study utilized 3 databases to obtain hospital admissions data: the National Hospital Morbidity Database for Australian hospital admissions data, the Hospital Episode Statistics database (HES) for England hospital admissions data, and the Patient Episode Database for Wales. Pneumonia hospitalization data were extracted utilizing J12 to J18 codes. From 2013 to 2020, there were 4,514,444 cases of pneumonia hospitalizations reported in Australia (646,515 [14.32%]), England (3,668,106 [81.25%]), and Wales (199,823 [4.43%]). The most common type of pneumonia hospitalization in Australia, England, and Wales was “pneumonia, organism unspecified,” accounting for 77.12%, 95.49%, and 95.75% of the total number of pneumonia hospitalizations in each country, respectively. The most common subtype of pneumonia hospitalization in Australia was “pneumonia, unspecified,” accounting for 72.98% of the total number of pneumonia hospitalizations in the country. The most common type of pneumonia hospitalization in England and Wales was “lobar pneumonia, unspecified,” accounting for 59.00% and 56.73% of the total number of pneumonia hospitalizations in each country, respectively. Most pneumonia hospitalizations in Australia, England, and Wales were non-same-day hospitalizations, accounting for 90.78%, 99.91%, and 99.95%, respectively. Pneumonia hospitalizations in Australia, England, and Wales were directly related to age. Males accounted for most pneumonia hospitalizations in Australia, England, and Wales. This study highlighted that hospitalization rate for pneumonia increased during the past decade in Australia, England, and Wales. The age and male gender were clearly contributing factors that affected pneumonia hospitalizations rate. Educational campaign aiming to increase public knowledge of pneumonia, its risk factors, and lifestyle modification should be prioritized to decrease pneumonia episodes.

PMID:40228257 | DOI:10.1097/MD.0000000000042163

Medicine (Baltimore). 2025 Apr 11;104(15):e41961. doi: 10.1097/MD.0000000000041961.

ABSTRACT

This research seeks to thoroughly examine the present state and research hotspots in Mendelian randomization (MR) in osteoporosis (OP)-related fields, providing a reference for future research directions in this area. Following an exhaustive search of the Web of Science Core Collection database, our analysis utilized citation statistics for osteoporosis studies conducted from January 1, 2007, through March 15, 2024. Bibliometric and visual analyses were conducted using two online analysis systems, CiteSpace and VOSviewer. The analysis included a variety of dimensions, including the distribution of citations, authorship, published journals, year of publication, countries, co-occurrence keywords and keyword clustering. From 2007 to 2024, the number of publications in MR in OP-related fields showed an overall increased. High-impact publications and leading contributors were primarily from China, followed by the USA and England. The journal with the largest number of publications in MR in OP-related fields is the Journal of Bone and Mineral Research. Risk factor research, genome-wide associations, meta-analysis, fractures, and gene loci were the main research hotspots. Interdisciplinary integration, MR research combined with data from clinical trials and observational studies, represents the future development trend. Research on MR in OP-related fields has mainly been conducted in China, the USA, and England. The research hotspots were aimed at exploring the causative between risk factors and OP. Future studies are likely to center on multidisciplinary integration.

PMID:40228251 | DOI:10.1097/MD.0000000000041961

Medicine (Baltimore). 2025 Apr 11;104(15):e42119. doi: 10.1097/MD.0000000000042119.

ABSTRACT

Autism Spectrum Disorder (ASD), characterized mainly by stereotyped behaviors and social impairments, affects about one in 100 children worldwide. Schizophrenia (SCZ), a chronic mental illness, affects 1% of the global population. The pathogenesis and specific treatment strategies for ASD and SCZ remain unclear. Previous research has suggested similarities in SCZ and ASD etiology and symptoms. However, no definitive correlation has been confirmed. Therefore, we conducted a Mendelian randomization study to assess the relationship between SCZ and ASD, providing new insights into their etiology and treatment. We used the two-sample Mendelian randomization (TSMR) approach to investigate the bidirectional causal association between SCZ and ASD, employing summary-level genome-wide association studies (GWAS) data. ASD summary data from the IEU GWAS database and SCZ summary data from the Psychiatric Genomics Consortium (PGC) were used as exposure and outcome variables, respectively. Statistical analysis was performed using the TwoSampleMR package in R version 4.3.2, with sensitivity analysis conducted to verify the result’s reliability. Based on the results of the MR analysis, we retrieved and analyzed the relevant genetic information from the GWAS Catalog. TSMR analysis revealed higher ASD risk in SCZ (IVW: OR: 1.19, 95% CI: 1.12-1.26, P < .001). Bidirectional MR analysis confirmed a causal relationship between ASD and SCZ (IVW: scz2018clozuk (Clozapine UK), OR: 1.12, 95% CI: 1.04-1.21, P = .003; scz2019asi, OR: 1.14, 95% CI: 1.05-1.23, P = .002). Our study demonstrated a bidirectional relationship between SCZ and ASD in the European population, suggesting that each may induce the onset of the other.

PMID:40228250 | DOI:10.1097/MD.0000000000042119