Category: Nevin Manimala

J Child Adolesc Psychiatr Nurs. 2026 Aug;39(3):e70062. doi: 10.1111/jcap.70062.

ABSTRACT

PURPOSE: This study aimed to determine the effects of a cognitive-behavioral therapy (CBT)-based psychoeducation program (the Social Media Addiction Reduction Psychoeducation Program (SMARPP), on university students’ social media addiction and self-control.

METHOD: The study used pre-test, post-test, and follow-up method with university students. Ninety-five students took part. Data were collected using a general information form, the Social Media Addiction Scale (SMAS), and the Short Self-Control Scale (SSCS). The data were analyzed using basic statistics such as number, percentage, average, and standard deviation, as well as independent sample t-tests and variance analysis.

RESULTS: The average age of the experimental group was 20.39 ± 1.81years, and that of the control group was 20.16 ± 2.09 years. In the experimental group, students’ SMAS total scores and subdimension scores (occupation, mood regulation, conflict, and repetition) decreased significantly. Their total SSCS scores went up significantly (p < 0.05). In the control group, there were no significant changes in the scores (p > 0.05).

CONCLUSION: The SMARPP effectively reduced university students’social media addiction and increased their self-control. In this regard, it is recommended that mental health nurses and psychological counselors working in schools apply the SMARPP.

PMID:42363867 | DOI:10.1111/jcap.70062

Future Oncol. 2026 Jun 27:1-9. doi: 10.1080/14796694.2026.2687697. Online ahead of print.

ABSTRACT

INTRODUCTION: Given the underrepresentation of adults aged ≥75 years with extensive-stage small-cell lung cancer (ES-SCLC) in clinical trials, we compared first-line chemoimmunotherapy versus chemotherapy in this population.

METHODS: This retrospective study enrolled 88 patients aged ≥75 years with ES-SCLC treated with either chemotherapy alone (n = 42) or chemoimmunotherapy (n = 46). The primary endpoint was overall survival (OS). Secondary endpoints included progression-free survival (PFS) and safety. Multivariable Cox regression and stabilized inverse probability of treatment weighting (IPTW) analyses were performed to reduce confounding.

RESULTS: Median OS and PFS were 14.3 (95% CI: 11.6-22.5) and 6.6 in the chemotherapy group and 16.9 (95% CI: 12.7-NA) and 7.6 months in the chemoimmunotherapy group, respectively (HR: 0.90, 95% CI: 0.51-1.58, p = 0.71; HR: 0.75, 95% CI: 0.43-1.29, p = 0.30, respectively). Multivariate analysis identified smoking status as an independent predictor of OS (HR: 2.10, 95% CI: 1.01-4.38, p = 0.048).

CONCLUSION: Among patients aged ≥75 years with ES-SCLC, chemoimmunotherapy was associated with numerically longer OS compared with chemotherapy alone, although this difference did not reach statistical significance.

PMID:42363803 | DOI:10.1080/14796694.2026.2687697

J Int Med Res. 2026 Jun;54(6):3000605261462010. doi: 10.1177/03000605261462010. Epub 2026 Jun 27.

ABSTRACT

ObjectiveTo evaluate the efficacy of small-incision, point-by-point debridement combined with double-cannula negative-pressure irrigation and drainage in the treatment of granulomatous mastitis.MethodsThis single-center, retrospective matched cohort study included 118 patients with granulomatous mastitis who were treated at the Third People’s Hospital of Mianyang between January 2022 and December 2024. Patients with comparable clinical characteristics were matched in a 1:1 ratio and assigned to either the treatment or control group, with 59 patients in each group. Patients in the treatment group underwent small-incision, point-by-point debridement of necrotic tissue combined with double-cannula continuous negative-pressure irrigation and drainage, whereas those in the control group underwent conventional incision and drainage combined with negative-pressure drainage. Postoperative drainage volume, time to drain removal, frequency of dressing changes, wound healing time, primary healing rate, recurrence rate, and breast shape score were compared between the two groups.ResultsCompared with the control group, the treatment group had a significantly lower postoperative drainage volume, fewer dressing changes, shorter time to drain removal, and shorter wound healing time. The recurrence rate was significantly lower in the treatment group than in the control group (χ² = 5.221, p < 0.05). The primary healing rate was significantly higher in the treatment group than in the control group (χ² = 4.140, p < 0.05). In addition, breast shape scores were significantly higher in the treatment group. All between-group differences were statistically significant.ConclusionSmall-incision, point-by-point debridement combined with double-cannula negative-pressure irrigation and drainage may promote wound recovery, reduce recurrence, and better preserve breast appearance in selected patients with granulomatous mastitis requiring surgical treatment. Further prospective studies are warranted to confirm these findings.

PMID:42363797 | DOI:10.1177/03000605261462010

J Int Med Res. 2026 Jun;54(6):3000605261463829. doi: 10.1177/03000605261463829. Epub 2026 Jun 27.

ABSTRACT

ObjectiveTo compare outcomes between immediate intraoperative dexamethasone implantation and scheduled 1-month postoperative dexamethasone implantation in pseudophakic eyes undergoing vitrectomy for diabetic macular edema with secondary epiretinal membrane.MethodsThis retrospective comparative study included 80 pseudophakic eyes with diabetic macular edema and secondary epiretinal membrane. All eyes underwent 25-gauge vitrectomy with epiretinal membrane and internal limiting membrane peeling. The Immediate Group $n=40$ received dexamethasone implantation at the end of vitrectomy, and the Delayed Group $n=40$ received the first dexamethasone implant 1 month postoperatively. From month 3, both groups followed the same pro re nata retreatment protocol. Best-corrected visual acuity, central macular thickness, intraocular pressure, and dexamethasone injection frequency were assessed for 12 months.ResultsBoth groups showed improvement in best-corrected visual acuity and reduction in central macular thickness, but early recovery was faster in the Immediate Group. At 1 month, best-corrected visual acuity was 0.55 ± 0.08 versus 0.78 ± 0.11 logarithm of the minimum angle of resolution, and central macular thickness was 315.5 ± 28.6 versus 520.2 ± 35.4 μm, respectively (both P < 0.001). Mixed-effects models showed significant time effects and significant group × time interactions at earlier visits, supporting greater early improvement in the Immediate Group. At 12 months, best-corrected visual acuity remained better in the Immediate Group (0.36 ± 0.08 vs. 0.43 ± 0.10 logarithm of the minimum angle of resolution, P = 0.001). Although central macular thickness remained lower in the Immediate Group, the group × time interaction for central macular thickness was no longer significant, indicating that the anatomical advantage became less pronounced over time. The Immediate Group showed numerically fewer dexamethasone injections, but without statistical significance. Intraocular pressure elevation was controlled medically, and no serious ocular or systemic adverse events were documented.ConclusionImmediate intraoperative dexamethasone implantation was associated with faster early anatomical recovery and earlier visual improvement. The anatomical advantage became less pronounced over time, and the potential effect on retreatment burden requires confirmation in prospective randomized studies.

PMID:42363796 | DOI:10.1177/03000605261463829

J Int Med Res. 2026 Jun;54(6):3000605261463455. doi: 10.1177/03000605261463455. Epub 2026 Jun 27.

ABSTRACT

ObjectiveHip and femur fractures in older adults are linked to high morbidity, mortality, and socioeconomic costs. This meta-analysis compares regional anesthesia and general anesthesia for these surgeries, focusing on perioperative safety and outcomes.MethodsFifteen studies (6829 participants) from 2009 to 2024 were analyzed. Primary outcomes included 30-day mortality, postoperative delirium, and cardiovascular events; secondary outcomes covered intraoperative blood loss, hospital stay, and pain. Pooled effect sizes were calculated using random-effects models with odds ratios and 95% confidence intervals. Heterogeneity was assessed using the I² statistic. Risk of bias was evaluated with Risk of Bias 2.0 (randomized controlled trials) and Risk Of Bias In Nonrandomized Studies of Interventions (observational studies). Certainty of evidence was rated using the Grading of Recommendations Assessment, Development and Evaluation approach.ResultsPooled analysis showed no significant difference in 30-day mortality between regional anesthesia and general anesthesia (odds ratio = 0.89 (0.72-1.10), p = 0.28, I² = 34%). Regional anesthesia was associated with significantly lower hypotension rates (odds ratio = 0.28 (0.18-0.43), p < 0.001, I² = 52%). There was a nonsignificant trend toward lower postoperative delirium with regional anesthesia (odds ratio = 0.78 (0.60-1.01), p = 0.06, I² = 46%). Pain management favored general anesthesia in one large trial (severe pain: 28.8% vs. 42.3%, p < 0.01), but other studies showed no difference. No significant differences were found in long-term mortality or functional recovery (p > 0.05 for all). Substantial heterogeneity (I² > 50%) was noted for some outcomes because of variations in age, fracture type, and study design.ConclusionRegional anesthesia may offer perioperative benefits, including reduced hypotension and a possible (but not statistically confirmed) reduction in postoperative delirium. General anesthesia provides better early pain control in some patients and remains suitable for complex cases. Individualized anesthesia plans are recommended. Future research should prioritize standardized outcomes and larger trials.

PMID:42363795 | DOI:10.1177/03000605261463455

J Nurs Manag. 2026;2026(1):e3436144. doi: 10.1155/jonm/3436144.

ABSTRACT

BACKGROUND: Nurses in resource-limited settings like Jordan require strong leadership and clinical judgment. Job rotation is believed to improve adaptability and self-efficacy, but its effect on clinical decision-making is unclear.

PURPOSE: This study aimed to examine whether job rotation mediates the relationship between clinical leadership skills and clinical decision-making among nurses.

METHODS: A cross-sectional correlational study was conducted among 395 registered nurses employed in Jordanian governmental hospitals. Participants were recruited using a proportional random sampling technique. Data were collected using validated questionnaires assessing clinical leadership skills, job rotation, and clinical decision-making. Statistical analyses, including ANOVA and regression analysis, were performed to examine relationships among the study variables. Structural equation modeling (SEM) was additionally used to assess mediation effects.

FINDINGS: The results showed significant differences between clinical decision-making and gender, marital status, and educational level. Clinical leadership significantly predicted decision-making (β = 0.433, 95% CI [0.331, 0.535], t = 8.226, p < 0.001). In contrast, job rotation indicated no significant direct effect (β = 0.000, 95% CI [-0.052, 0.051], t = -0.010, p = 0.992) and did not mediate the relationship between leadership and decision-making (β = 0.008, 95% CI [-0.041, 0.057], t = 0.325, p = 0.745).

CONCLUSION: Leadership skills were significantly associated with nurses’ clinical decision-making, and leadership development may play a more substantial role in clinical decision-making than job rotation within this sample.

IMPLICATION FOR NURSING MANAGEMENT: Job rotation implementation has to be intentional, by putting real effort into structured training, mentoring, and embedding workplace learning into daily routines, which improves decision-making quality, increases professional confidence, and ultimately enhances patient outcomes.

PMID:42363792 | DOI:10.1155/jonm/3436144

Nucleic Acids Res. 2026 Jun 27:gkag420. doi: 10.1093/nar/gkag420. Online ahead of print.

ABSTRACT

Computational methods are central to the life sciences. The rapid growth and diversification of software tools and databases make it difficult to find, compare, and reuse methods for a given task. bio.tools is a community-driven registry designed to improve the visibility of research software and allow researchers to simplify access to the software ecosystem through structured, interoperable, and accessible metadata. Tools are annotated using the EDAM ontology and additional controlled vocabularies, enabling users to search and filter by scientific topics, operations, input/output data types, and data formats. bio.tools supports interactive exploration via rich tool landing pages and provides programmatic access through a documented API for search, retrieval, and registry statistics. The registry has expanded to almost 33,000 annotated tools through the combined contributions of thousands of community members and semi-automated literature mining that keep the registry up to date. Recent improvements to the registry include machine-assisted scoring to prioritise curator review, and consolidation of both its standards stack and software architecture. bio.tools has also become a foundational upstream metadata source that is reused by other services in the ELIXIR Research Software Ecosystem and beyond, to support synchronisation, cross-linking, and additional downstream services. bio.tools is freely available at https://bio.tools.

PMID:42363751 | DOI:10.1093/nar/gkag420

J Psychosoc Oncol. 2026 Jun 27:1-16. doi: 10.1080/07347332.2026.2692942. Online ahead of print.

ABSTRACT

OBJECTIVE: This study sought to understand the differences in how young adults with various cancer predisposition syndromes (CPS) feel toward disclosing their diagnosis to romantic partners.

METHODS: Young adults with a CPS completed a cross-sectional survey. Data analysis of 158 responses was performed via SPSS v 27.0 descriptive statistics. One-way ANOVA analyses, and post-hoc pairwise comparisons examining CPS, gender, and sexual orientation were performed.

RESULTS: Individuals with Lynch syndrome favored disclosing later in a relationship compared to those with Li-Fraumeni syndrome (LFS) (p = 0.050). Individuals who identified as bisexual preferred disclosing more information about their CPS than those who identified as heterosexual (p = 0.035).

CONCLUSIONS: Individuals with various CPS experience a myriad of feelings and attitudes surrounding dating and disclosure. This information can lead to better sensitivity and awareness of this topic by healthcare providers, ultimately improving the level of care given to these individuals.

PMID:42363725 | DOI:10.1080/07347332.2026.2692942

Biopreserv Biobank. 2026 Jun 27:19475535261448800. doi: 10.1177/19475535261448800. Online ahead of print.

ABSTRACT

BACKGROUND: The Kids Eye Biobank collects biospecimens, images, and clinical data from pediatric ophthalmology patients for future research use. A broad informed consent model is used; participants have opt-in choices, which include the creation of cell lines/organoids, use of whole genome sequencing (WGS) data, sharing resources with industry, and receiving future communications. This study aimed to characterize participant consent preferences and investigate associations between participant characteristics and their consent preferences.

METHODS: Participant demographics, diagnosis, and consent preferences were abstracted from the Kids Eye Biobank’s records. Variables were analyzed using descriptive statistics and chi-square test. Patient engagement methods were used throughout the study.

RESULTS: Between January 2020 and April 2025, 391 patients were approached and 342 (87%) enrolled. Of the enrolled participants, 265 (78%) had a substitute decision-maker, and 205 (60%) were diagnosed with a malignant neoplasm affecting the eye. Demographic data were available for 273 (80%) participants; 50% were boys/men, 48% identified as belonging to a visible racial minority, and 67% reported a religious affiliation. Participants with malignant neoplasms opted in more to the use of WGS data and to the sharing of WGS data and cell lines/organoids with industry (p < 0.05). Participants belonging to a visible racial minority opted in less to the generation of cell lines/organoids (p < 0.05) and to receiving communications about future research (p = 0.002) compared with White participants.

CONCLUSION: Informed consent preferences may be influenced by participant diagnosis and/or race. These findings may help the Kids Eye Biobank tailor its communication strategies and diversify its participant population.

PMID:42363713 | DOI:10.1177/19475535261448800

J Adolesc Young Adult Oncol. 2026 Jun 27:21565333261464968. doi: 10.1177/21565333261464968. Online ahead of print.

ABSTRACT

PURPOSE: Adolescents and young adults (AYAs) with cancer are at risk for treatment-related infertility, yet gaps in fertility preservation (FP) counseling persist. While patient-level barriers are well described, provider-level factors remain understudied. We evaluated oncology providers’ perceived versus demonstrated knowledge of FP guidelines and identified barriers to oncofertility care.

METHODS: We conducted a cross-sectional survey of oncology providers at a single academic medical center caring for postpubertal AYA patients receiving gonadotoxic therapy. The survey assessed demographics, prior FP training, counseling and referral practices, and perceived barriers. Participants self-rated their FP knowledge and completed guideline-based clinical vignettes to assess demonstrated knowledge, enabling direct comparison of perceived versus demonstrated knowledge.

RESULTS: Providers reported limited formal oncofertility training, with most rating prior education as fair or poor. Knowledge varied across FP strategies, with high familiarity for ovarian suppression and sperm cryopreservation and lower familiarity for ovarian transposition and male-directed surgical techniques. A trend toward discordance between perceived and demonstrated knowledge was observed but was not statistically significant. Awareness of institutional FP resources and referral pathways was limited. Providers most frequently cited patient-level barriers, including treatment urgency and cost, although provider- and system-level barriers were also reported.

DISCUSSION: Oncology providers may overestimate oncofertility knowledge, contributing to inconsistent counseling and missed opportunities for FP. This pattern, combined with gaps in training and awareness of institutional protocols, highlights the need for competency-based education, clearer institutional communication, and improved referral systems. Objective assessments may better identify knowledge gaps and guide targeted interventions to support guideline-concordant FP care.

PMID:42363674 | DOI:10.1177/21565333261464968