Category: Nevin Manimala

Rheumatology (Oxford). 2026 Jan 10:keag016. doi: 10.1093/rheumatology/keag016. Online ahead of print.

ABSTRACT

OBJECTIVES: Several studies reported an association between Sjögren’s disease (SjD) and inclusion body myositis (IBM). However, the potential specificities of IBM when associated with SjD have been poorly investigated. Here, we compared the muscular inflammatory infiltrates between IBM patients with or without associated SjD.

MATERIALS AND METHODS: Formalin-fixed and paraffin-embedded muscle biopsies of patients with IBM, associated with SjD (IBM-SjD) and sporadic (sIBM) forms, from 6 French expert centers, were collected. Imaging mass cytometry (IMC) multiplex immunostaining (34 markers) was used to quantify and analyze inflammatory infiltrate composition. Supervised and unsupervised descriptive and comparative analyses were performed.

RESULTS: Fourteen IBM-SjD and 7 sIBM muscle samples were analyzed. No statistically significant difference was encountered but some trends were pointed. IBM-SjD samples had a broader inflammatory infiltrate surface (median 4.8%, IQR: 1.4-8.6) than sIBM samples (median 1.6% IQR: 1.2-2.4). In both groups, the main inflammatory cells in muscle infiltrate were primarily macrophages and T cells. However, the proportion of plasma cells (14.7% IQR: 5.4-24.6 vs 8.5% IQR: 4.6-9.8) and B cells (3.1% IQR: 0.4-5.6 vs 0.5% IQR: 0.0-3.2) were higher in IBM-SjD patients.

CONCLUSION: Using IMC on muscle biopsies, IBM-SjD and sIBM patients share common histological features, but there are notable distinctions (more extensive infiltrate, high numbers of B cells and plasma cells in IBM-SjD). These observations were exploratory and based on a small number of patients. but may suggest IBM-SjD has distinct SjD-related pathophysiology compared with sIBM, and open to further research with potential diagnostic and therapeutic implications.

PMID:41520169 | DOI:10.1093/rheumatology/keag016

Oncologist. 2026 Jan 10:oyag003. doi: 10.1093/oncolo/oyag003. Online ahead of print.

ABSTRACT

PATIENTS AND METHODS: we retrospectively collected data of patients with HR+/HER2- advanced breast cancer (ABC) treated with endocrine therapy (ET) and a CDK4/6 inhibitor (CDK4/6i) aiming to describe the patterns of post-progression outcomes.

RESULTS: Among 452 evaluable patients 325 were treated in the first-line setting. Median progression free-survival (mPFS) was 22.8 months overall and 29.7 months in patients treated in first-line setting. Factors associated with outcomes in multivariate analysis were the line of CDK4/6i therapy, de novo vs recurrent disease, visceral vs bone-only metastases, and primary endocrine resistance.A total of 300 patients progressed and 250 overall and 156 in the first-line cohort received a subsequent treatment. Visceral progression and CDK4/6i duration <12 months were associated with a higher likelihood of receiving anthracycline or taxanes (AT) as compared to ET ±everolimus (EET). Post-progression PFS (PPFS) and post-progression OS (PPOS) were statistically significantly better with EET and capecitabine (C) arms over AT overall and in patients with visceral progression. Multivariate analysis confirmed a significant advantage for EET and C, while visceral progression retained a significant impact only on PPOS. After progression to the 1st post-CDK4/6i treatment C obtained a significant better PPOS as compared to other treatments.

CONCLUSION: we showed in a large real-world series that most patients with HR+/HER2- ABC failing CDK4/6i and ET unselected for the occurrence of molecular mutations retain endocrine sensitivity and may benefit of a subsequent ET ± a targeted therapy delaying the need for chemotherapy regardless of site of progression and prior CDK4/6i therapy duration.

PMID:41520162 | DOI:10.1093/oncolo/oyag003

Interdiscip Cardiovasc Thorac Surg. 2026 Jan 10:ivag017. doi: 10.1093/icvts/ivag017. Online ahead of print.

ABSTRACT

OBJECTIVES: Extended arch replacement (EAR) and hemiarch replacement (HAR) are surgical options for type A acute aortic dissection (AAD). However, the effectiveness of EAR compared with HAR, particularly in elderly patients, remains unclear owing to its invasiveness and complications. This study aimed to compare the postoperative outcomes of EAR and HAR in elderly patients with type A AAD.

METHODS: This retrospective cohort study used data from the Shizuoka Kokuho Database, a prefecture-wide, multi-institutional administrative claims database managed by the Shizuoka Prefectural Government. We identified patients aged ≥60 years with type A AAD who underwent HAR or EAR between April 2012 and September 2022. Propensity score matching was employed to balance the baseline characteristics between the groups. The primary outcome was all-cause mortality. The secondary outcome included the incidence of reoperation for bleeding.

RESULTS: A total of 774 patients were included (174 undergoing EAR and 600 undergoing HAR). After propensity score matching, 167 matched pairs were analyzed. Kaplan-Meier curves revealed no significant differences in survival between both procedures (log-rank test, p = 0.739). Cox proportional hazards analysis also revealed no significant differences in all-cause mortality between the EAR and HAR groups (hazard ratio: 1.08, 95% confidence interval: 0.70-1.66). However, the incidence of reoperation for bleeding was higher in the EAR group than in the HAR group (20 [12.0%] vs 7 [4.2%], p = 0.012).

CONCLUSIONS: Although no statistically significant difference in postoperative mortality was observed between EAR and HAR, the incidence of reoperation for bleeding was higher in the EAR group. Therefore, the indication for EAR in elderly patients with type A AAD should be considered with caution.

PMID:41520161 | DOI:10.1093/icvts/ivag017

Disabil Rehabil. 2026 Jan 10:1-25. doi: 10.1080/09638288.2025.2611576. Online ahead of print.

ABSTRACT

PURPOSE: To evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) on gait and brain alteration in cerebral palsy (CP) children.

MATERIALS AND METHODS: MEDLINE, Scopus, Google Scholar, Web of Science, and Cochrane were searched in February 2024 and updated in 9 October 2025. Randomized controlled trials (RCTs) with CP participants under 18, rTMS or tDCS intervention, and gait assessment were included. The risk of bias was assessed, and a meta-analysis was conducted using random-effect models.This review was registered in PROSPERO (ID: CRD42024555049).

RESULTS: 21 studies met the inclusion criteria. tDCS led to significant improvements in velocity (MD = 0.17, 95% CI = 0 to 0.35), gross motor function measure (GMFM), and functional independence. However, changes in other parameters such as step length, and cadence were not statistically significant and showed high heterogeneity. rTMS also improved overall motor function and walking performance in several studies, though data variability prevented meta-analysis. Both methods were safe and well-tolerated.

CONCLUSION: Both interventions showed promise for improving velocity and GMFM in children with CP. However, due to inconsistent findings across other gait parameters and substantial heterogeneity, further large-scale, standardized RCTs with neuroimaging assessments are needed.

PMID:41518074 | DOI:10.1080/09638288.2025.2611576

Colorectal Dis. 2026 Jan;28(1):e70358. doi: 10.1111/codi.70358.

ABSTRACT

AIM: Neoadjuvant treatment for rectal cancer has evolved markedly with the growing adoption of total neoadjuvant therapy (TNT), organ-preservation strategies and selective omission of radiotherapy. Recent trials support risk-based personalization, but its application in real-world settings remains poorly documented. The aim was to describe current neoadjuvant treatment practices for mid-low rectal cancer in French expert centres and identify tumour- and patient-related factors influencing decisions.

METHOD: This observational study included patients with non-metastatic rectal adenocarcinoma ≤10 cm from the anal verge, discussed in tumour boards (October 2022 to March 2023) across GRECCAR centres. Tumours were classified as early, intermediate-risk or locally advanced rectal cancer (LARC). Neoadjuvant treatments were analysed according to tumour extension, location and age.

RESULTS: Among 463 patients from 27 centres, the most frequent regimen was induction chemotherapy, mainly FOLFIRINOX, followed by long-course chemoradiotherapy (CRT) (65%). This approach was used in 51%, 66% and 71% of patients in the early, intermediate-risk and LARC groups, respectively (p = 0.0060). TNT was more frequently administered for low- than mid-rectal cancers, especially in LARC (86% vs. 71%, p = 0.016). In patients >75 years, CRT + consolidation chemotherapy and radiotherapy alone were proportionally more frequent. Among the early rectal cancers, those treated with induction chemotherapy + CRT had more advanced features than those treated with CRT alone (cT3: 80% vs. 43%, cN+: 62% vs. 10%, tumour size: 3.4 vs. 2.3 cm; all p < 0.001).

CONCLUSION: TNT with induction chemotherapy is the predominant neoadjuvant approach in French expert centres. Tumour classification, location and patient age significantly influence treatment choices, reflecting a shift towards personalized context-specific care.

PMID:41518072 | DOI:10.1111/codi.70358

Appl Neuropsychol Child. 2026 Jan 10:1-8. doi: 10.1080/21622965.2025.2611932. Online ahead of print.

ABSTRACT

Sensory processing plays a critical role in children’s ability to engage in social interactions and participate in daily activities. This study examines the associations between sensory processing skills, social skills, and participation in kindergarten children. A total of 88 children aged 4-7 years were included. The Sensory Processing Measure (SPM), Social Skills Scale (SSS), and Child and Adolescent Participation Scale (CASP) were completed by parents. The SPM total score was significantly negatively correlated with social cooperation (r = -.45, p < .001), self-regulation (r = -.51, p < .001), and assertion (r = -.42, p < .001). Similarly, significant negative correlations were observed between SPM and CASP in home (r = -.55, p < .001), community (r = -.43, p < .001), and school (r = -.44, p < .001) settings, as well as with home and community living activities (r = -.34, p = .001). Regression analysis showed that both sensory processing (β = -.37, p < .001) and social skills (β = .39, p < .001) were statistically significant predictors of participation, explaining 43.4% of the variance (R² = 0.434, F = 30.318, p < .001). These findings highlight the importance of early identification and intervention for addressing sensory processing issues, thereby enhancing participation and social development in early childhood.

PMID:41518063 | DOI:10.1080/21622965.2025.2611932

Am J Biol Anthropol. 2026 Jan;189(1):e70202. doi: 10.1002/ajpa.70202.

ABSTRACT

OBJECTIVES: Traits found in a skeletal sample are frequently used to infer qualities of the living population from which the skeletons were drawn. However, traits observed in a mortality sample may exhibit biological mortality bias in that they may not accurately represent the same traits in the living sample. The purpose of this research was to assess biological mortality bias in deciduous tooth emergence, a trait that is used to estimate chronological age in skeletal samples.

MATERIALS AND METHODS: Data on clinical tooth emergence were collected from longitudinal studies of Javanese, Guatemalan, and Bangladeshi children that included a living sample (those who survived through the study) and a mortality sample (those who died during the study). Parametric hazards analysis was used to test for differences in the timing of tooth emergence between the living and mortality samples.

RESULTS: There were no significant differences between the living and mortality samples for Bangladesh and Java, although there was a trend toward delayed emergence in the Bangladesh mortality sample. The Guatemalan mortality sample exhibited advanced emergence of the posterior dentition for the mortality sample. No evidence of biological mortality bias was found in pooled analyses of the Bangladesh and Java samples or pooled analyses of all three samples.

DISCUSSION: We found limited evidence that deciduous tooth emergence in a mortality sample (e.g., a skeletal series) would differ from the timing of emergence in the living population from which the mortality sample was drawn.

PMID:41518048 | DOI:10.1002/ajpa.70202

Med Teach. 2026 Jan 10:1-10. doi: 10.1080/0142159X.2025.2604240. Online ahead of print.

ABSTRACT

INTRODUCTION: The integration of artificial intelligence (AI) tools into medical education presents new opportunities for enhancing students’ research skills and scientific writing. However, concerns remain about the potential for cognitive disengagement and the ethical use of AI when lacking appropriate educational supervision. This study aimed to evaluate a novel educational strategy combining structured AI assistance with mentor guidance to support narrative review writing among third-year medical students.

METHODS: A structured framework was implemented during the endocrine module, involving AI-assisted objective formulation, mentor-guided objective refinement, literature search and summarization, review drafting followed by AI-assisted rephrasing. Students worked in groups, each supervised by a trained mentor. A validated questionnaire assessed student perceptions across four domains: framework and guidelines, AI-generated objectives, skills developed and mentor role, and overall satisfaction. Descriptive statistics were performed and chi-square tests evaluated associations between perceptions and AI tool usage (ChatGPT vs. DeepSeek).

RESULTS: Eighty-seven students completed the survey. Perceived improvement in research readiness was observed; confidence in literature searching rose from 29.8% to 69%, while 75.8% reported increased familiarity with PubMed/Google Scholar. Most students (80.5%) expressed satisfaction with the AI mentor hybrid approach, and 82.8% agreed it prepared them for future research. There were no significant differences in perceived outcomes between AI tools used. Mentor involvement was deemed essential by 69% of students, and a minority believed AI alone could replicate the same outcomes. Common challenges included limited access to articles and peer collaboration difficulties, while key learning outcomes included improved summarization and ethical AI use.

DISCUSSION: This study supports the integration of AI tools within a structured, mentor-guided educational framework to enhance critical evaluation and scientific writing in medical education. Human oversight and mentorship drive skill development and minimize the risk of unmoderated AI use in academic settings.

PMID:41518042 | DOI:10.1080/0142159X.2025.2604240

J Esthet Restor Dent. 2026 Jan 10. doi: 10.1111/jerd.70104. Online ahead of print.

ABSTRACT

OBJECTIVE: This study aimed to evaluate the tensile bond strength of polyetheretherketone (PEEK) hybrid abutments bonded to titanium (Ti) and chromium-cobalt (Cr-Co) bases using two adhesive systems or the heat-pressing technique.

MATERIALS AND METHODS: Ninety PEEK abutments were fabricated using titanium or cobalt-chromium bases: 60 milled from BioHPP blocks and cemented with MKZ Primer-DTK or Monobond Plus-Multilink Hybrid (n = 15) and 30 produced by heat-pressing technique. Tensile bond strength was measured and failure modes were evaluated under a stereomicroscope. Statistical analysis was performed using two-way robust ANOVA with Bonferroni correction (α = 0.05).

RESULTS: Both the bonding method and the interaction between method and base materials had a statistically significant effect on bond strength (p < 0.001). The heat-pressing technique resulted in higher bond strength than the resin cement groups (p < 0.001). The highest bond strength was observed in the Cr-Co heat-pressed group (124 MPa) (p < 0.001). All failures in the cemented groups were adhesive type. In the Cr-Co heat-pressed group, failures were cohesive and mixed. In the titanium heat-pressed group, failures were adhesive and mixed.

CONCLUSION: The heat-pressing technique significantly improved the bond strength of PEEK abutments compared with resin cementation. Cr-Co bases also demonstrated favorable bonding with PEEK using the heat-pressing technique.

CLINICAL SIGNIFICANCE: The heat-pressing technique improved the bond strength of PEEK abutments to titanium and cobalt-chromium bases.

PMID:41518024 | DOI:10.1111/jerd.70104

J Esthet Restor Dent. 2026 Jan 10. doi: 10.1111/jerd.70082. Online ahead of print.

ABSTRACT

OBJECTIVES: To evaluate the influence of head posture on the accuracy of occlusal contacts at maximum intercuspal position (MIP) recorded by an intraoral scanner.

METHODS: Occlusal contacts of 46 individuals were initially located using articulating film (8 μm, Accufilm, FastCheck; Parkell). The located contacts were digitized with an intraoral scanner (IOS, Trios 4; 3Shape) by obtaining maxillary and mandibular scans. Bilateral virtual occlusal records in MIP were acquired by setting the dental chair in two different positions: upright (90° to the horizontal plane) and supine (0° to the horizontal plane). In both positions, occlusal contacts were also recorded using a digital occlusal analysis system (T-Scan Novus, Tekscan). Two calibrated examiners evaluated occlusion attribution, using the digitized contacts from the articulating film as the reference. Statistical analysis was performed using one-way ANOVA followed by pairwise multiple comparisons (α = 0.05).

RESULTS: Head posture did not significantly affect the proportion of coinciding occlusal contacts at MIP between the reference and those identified by the IOS and the digital occlusal analysis system, both for the full arch and individual sections. The digital occlusal analysis system, however, recorded a higher number of false occlusal contacts in the supine position compared to the upright position.

CONCLUSIONS: The use of IOS to locate the occlusal contacts at MIP was not impacted by the evaluated head postures. In contrast, head posture had a significant effect on the recordings obtained with the digital occlusal analysis system.

CLINICAL SIGNIFICANCE: Intraoral scanning provides reliable MIP acquisition in both upright and supine positions. However, digital occlusal analysis is sensitive to changes in head posture; therefore, recording in the upright patient position is recommended for greater accuracy.

PMID:41518020 | DOI:10.1111/jerd.70082