Category: Nevin Manimala

Adv Exp Med Biol. 2026;1489:375-384. doi: 10.1007/978-3-032-03394-9_36.

ABSTRACT

PURPOSE: To confirm the validity and reliability of the Greek version of the Clinical Cultural Competency Questionnaire (CCCQ) among mental healthcare professionals.

METHODOLOGY: A cross-sectional study was conducted with a convenience sample of 290 mental health professionals who worked in two psychiatric hospitals of Athens. Internal reliability, content validity, and construct validity were estimated. We conducted factor analysis in order to estimate the structure of the questionnaire.

RESULTS: Our six-factor model explained 67.0%of the variance and included the following factors: (a) knowledge, (b) skills, (c) encounter situation, (d) attitude, (e) awareness, and (f) education/training. All subscales resulting from the factor analysis had alphas that ranged from 0.72 to 0.93. Correlations among the scales were all statistically significant. Higher scores in all subscales were observed for mental health care professionals who had attended transcultural health care courses and had social interactions with people from different cultural backgrounds.

CONCLUSIONS: The Greek version of CCCQ was found to be a clear, valid, and reliable tool to assess the cultural competence of mental healthcare professionals.

PMID:41252023 | DOI:10.1007/978-3-032-03394-9_36

Adv Exp Med Biol. 2026;1489:347-356. doi: 10.1007/978-3-032-03394-9_34.

ABSTRACT

INTRODUCTION: Burns are injuries with local and systemic responses that cause severe complications to all systems in human body. Patients with moderate or severe burn injury are likely, over time, to develop metabolic, motor, psychiatric, and social disorders. The aim of this study was to explore the quality of life, post-traumatic stress disorder and insomnia in individuals with burn injuries.

MATERIAL AND METHODS: This cross-sectional study included adults with burn injuries in any area of the body. The research tools were BSHS-B, 5Q-5D-5L, ABSI, AIS, and IES-R which also included variables from medical or nursing documentation and records as well as reports from patients. Statistical significance was set at p < 0.05 and analyses were conducted using SPSS statistical software (version 26.0).

RESULTS: In the present study were enrolled 45 outpatients with burns. The findings revealed that insomnia was significantly associated with lower scores in Simple Abilities (p = 0.006), Treatment Regimen (p = 0.033), Heat Sensitivity (p = 0.005), Affect (p < 0.001), Sexuality (p = 0.023), Interpersonal Relationship (p = 0.046) domains of the BSHS-B index, as well as with the total BSHS-B score (p = 0.004). Greater Avoidance (p = 0.050) and Hyperarousal (p = 0.011) domains, as also the total IES-R scores (p = 0.018) of the IES-R scale were significantly associated with lower Simple abilities score of BSHS-B index.

CONCLUSION: There is a clear and urgent need for the continuation of this study with a larger sample, representative of the population, and over an extended period of time to produce more sufficient and significant statistical results.

PMID:41252021 | DOI:10.1007/978-3-032-03394-9_34

Adv Exp Med Biol. 2026;1489:335-345. doi: 10.1007/978-3-032-03394-9_33.

ABSTRACT

Abdominal aortic aneurysm (AAA) is one of the leading causes of death worldwide. Considering that most AAAs remain asymptomatic until they are close to rupture, an efficient workflow for the accurate detection and delineation is crucial for the clinical outcome. In this study, we conduct a comparative analysis of two different AAA segmentation algorithms using X-ray Computed Tomography (CT) images from 18 patients diagnosed with AAA, which have not been used in similar studies before. The methodologies employed include an in-house segmentation algorithm based on conventional image analysis techniques, and a deep learning approach based on the nnU-Net -framework called TotalSegmentor. The CT dataset, which contained baseline studies, was processed, and the manual annotations by clinicians were used as ground truth. Results demonstrated a high degree of accuracy and robustness, with TotalSegmentor achieving an average Sorensen-Dice coefficient of 0.89 and Jaccard index of 0.81 across the dataset, compared to the proposed unsupervised method’s scores of 0.85 and 0.77, respectively. These findings highlight the potential of deep learning-based models to enhance clinical workflows, ultimately improving early detection and monitoring of AAA.

PMID:41252020 | DOI:10.1007/978-3-032-03394-9_33

Adv Exp Med Biol. 2026;1489:297-304. doi: 10.1007/978-3-032-03394-9_30.

ABSTRACT

The preference for the gender of physicians has been the subject of numerous studies, primarily conducted abroad. Several of these studies reveal that a considerable number of female patients prefer to consult with a female doctor, especially for issues related to gynecological care. This study aimed to: (a) investigate patient preferences regarding the gender of physicians in pulmonology, (b) explore factors related to these preferences, and (c) examine the relationship between gender preferences and health locus control among the treated individuals.

METHODS: A cross-sectional study design was applied in this study. Data were collected using a self-administered questionnaire. The questionnaire consists of three parts: The first part includes questions related to the demographic characteristics of the sample (age, profession, education, etc.). The second part of the questionnaire consists of a specially designed section that examines (a) gender preferences for the pulmonologist, (b) age preferences of the physician, and (c) reasons for choosing a specific gender, such as knowledge and skills, communication, etc. Finally, the third part of the questionnaire includes the Health Locus of Control scale. The statistical software package for social sciences (SPSS), version 25.0, was utilized for data analysis. The level of statistical significance will be set at 0.05.

RESULTS: According to the results, the majority of the participants didn’t have a specific preference, but if they did, they favored female pulmonologists over men. Moreover, only monthly income emerged as a significant associated factor for pulmonologist gender preference.

CONCLUSION: The majority exhibited no specific preference, but among those who did, a preference for female pulmonologists over males was observed. Monthly income emerged as a significant factor associated with pulmonologist gender preference.

PMID:41252017 | DOI:10.1007/978-3-032-03394-9_30

Adv Exp Med Biol. 2026;1489:69-76. doi: 10.1007/978-3-032-03394-9_7.

ABSTRACT

This research aims to analyze discrimination experienced by individuals with di verse gender identities and sexual orientations in their daily lives when seeking medical assistance, and its impact on their quality of life. Conducted as a cross-sectional study, it utilized a questionnaire developed based on the 2019 Southern LGBTQ Health Survey. Linear regression analysis identified factors influencing difficulties accessing health and public services, and Quality of Life SF-12 scores. The sample comprised 152 individuals, predominantly aged 18-30, female, and identifying as bisexual. Most resided in urban areas and were educated, yet a significant part of them were unemployed. While many preferred private clinics for medical care, few delayed seeking care due to LGBTQ+ identity. Participants reported workplace difficulties and experienced violence, correlating with poorer physical and mental health. Positive opinions about healthcare services corresponded to better mental health. Educational level and employment status influenced mental well-being. Exclusion from healthcare and public services detrimentally affected LGBTQ+ individuals’ mental health, emphasizing the need for inclusive policies, education for healthcare professionals, and specialized services. Efforts to promote inclusion across social groups are imperative for enhancing overall well-being and ensuring equitable access to healthcare.

PMID:41251994 | DOI:10.1007/978-3-032-03394-9_7

Adv Exp Med Biol. 2026;1489:37-45. doi: 10.1007/978-3-032-03394-9_4.

ABSTRACT

BACKGROUND: Covid-19 vaccinations of the general population and special groups such as football players are expected to reduce the transmission of disease and achieve herd immunity.

METHODS: We conducted a cross-sectional study among professional football players in Greece via an online survey prepared using Google Forms. The study was conducted during the period April-June 2022. In this study, we aimed to assess the knowledge and attitude of professional football players inthe second division of Greece’s football league, together with their vaccination coverage against Covid-19.

RESULTS: We found that the majority of participants were fully vaccinated against Covid-19 (72% vaccination coverage). Since the start of the pandemic, 70.4% of the football players had been diagnosed with Covid-19. A significant difference in Covid-19 vaccination was reported, with players who believed that vaccines are important for public health in comparison to counterparts that were opposed to that (p-value = 0.000005, CI = 1.422-18.34). Players with trust of health professionals also showed higher Covid-19 vaccination rates relative to players who did not against Covid-19 (p-value <0.0000001; CI = 2.906-41.64). A small proportion of medical staff of football teams recommended vaccination against the Covid-19 pandemic to football players.

CONCLUSIONS: Targeting the holistic approach of knowledge of football players’ vaccination, it may have an impact to next generation’s vaccination’s behavior and knowledge, that will eventually lead to the existence of future influencers for vaccination campaigns.

PMID:41251991 | DOI:10.1007/978-3-032-03394-9_4

J Clin Exp Neuropsychol. 2025 Nov 18:1-11. doi: 10.1080/13803395.2025.2579873. Online ahead of print.

ABSTRACT

BACKGROUND: Hyperbaric oxygen (HBO₂) treatment is used to treat a variety of conditions, but its effects on cognitive functioning are inconsistently assessed. This scoping review identifies the current literature on cognitive testing in relation to HBO₂ treatment.

OBJECTIVE: We aimed to 1) identify which cognitive domains have been investigated in relation to HBO₂; 2) identify the neurocognitive tests used; and 3) propose a standardized cognitive assessment program applicable to future HBO₂ clinical trials.

METHODS: A systematic search of four databases was conducted up to March 2025 for clinical studies involving adult patients treated with HBO₂, with neurocognitive testing as one of the outcomes. Cognitive domains were categorized using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria, and test sensitivity was evaluated in randomized controlled trials.

RESULTS: Of 3,238 records, 98 studies published between 1963 and 2025 met the inclusion criteria. The findings reveal considerable variation in the cognitive domains investigated and in the assessment methods employed, reflecting the diversity of disorders treated and a lack of consensus in the field of HBO₂ treatment. To improve consistency and comparability across future HBO₂ research, we propose a standardized, computerized cognitive test battery assessing psychomotor speed, attention, memory, and executive function.

PMID:41251096 | DOI:10.1080/13803395.2025.2579873

Brain Behav. 2025 Nov;15(11):e71087. doi: 10.1002/brb3.71087.

ABSTRACT

BACKGROUND: To identify genetic loci associated with Parkinson’s disease (PD) through a genome-wide meta-analysis, to screen for druggable genes significantly linked to PD risk, and evaluate their potential as therapeutic targets.

METHODS: Data from DGIdb, GeneCards, and the Finan genomic resource were integrated to identify candidate therapeutic genes associated with PD. Genome-wide meta-analysis was conducted using GWAS data from the International Parkinson’s Disease Genomics Consortium and FinnGen, involving 1,851,374 participants. Mendelian randomization (MR), colocalization analysis, and phenome wide association studies (PheWAS) were conducted to validate the associations between the identified genes and PD. Furthermore, knockout mouse models from the Mouse Genome Informatics were analyzed to validate PD-related phenotypes, and DSigDB was utilized to predict potential therapeutic compounds.

RESULTS: We identified several therapeutic genes significantly associated with PD risk. Colocalization analysis suggested shared causal genetic variants between these genes and PD. PheWAS further revealed that GCLC and GFPT1 exhibit limited pleiotropic effects across other traits. Eight potential compounds were identified through DSigDB predictions.

CONCLUSION: Through genome-wide meta-analysis, MR, colocalization, and PheWAS, we identified genetic loci associated with PD and assessed GCLC and GFPT1 as potential therapeutic targets.

PMID:41251092 | DOI:10.1002/brb3.71087

J Health Psychol. 2025 Nov 18:13591053251386383. doi: 10.1177/13591053251386383. Online ahead of print.

ABSTRACT

This study aimed to understand the status of undergraduate nursing students’ subjective well-being and psychological flexibility in China, and to explore their correlation, providing evidence for psychological health interventions. A cross-sectional study was conducted involving 1609 full-time undergraduate nursing students from 20 Chinese universities, by convenience and snowball sampling. Data were collected using a general information questionnaire, Index of Well-being and Index of General Affect, and Comprehensive assessment of Acceptance and Commitment Therapy processes. Statistical analyses were performed using SPSS25.0. The findings revealed that Chinese undergraduate nursing students had moderate subjective well-being and psychological flexibility. Students with higher psychological flexibility demonstrated greater subjective well-being, and vice versa. Among dimensions of psychological flexibility, behavioural awareness was the most significant contributor to higher subjective well-being. These results provide theoretical evidence on current status of their subjective well-being and psychological flexibility, highlighting the importance of better psychological flexibility to higher subjective well-being.

PMID:41251076 | DOI:10.1177/13591053251386383

Small. 2025 Nov 18:e09928. doi: 10.1002/smll.202509928. Online ahead of print.

ABSTRACT

This investigation demonstrates the cold sintering process (CSP) enabling remarkable densification of microporous zeolite 13X while preserving intrinsic structural integrity. Using sequential one-factor-at-a-time optimization, both H₂O- and NaOH-assisted CSP pathways are comprehensively evaluated through XRD, TGA, SEM, HR-TEM, BET analysis, and statistical validation. Water-assisted CSP (10 wt.%, 350 MPa, 220 °C, 90 min, 5 °C min^-1) achieves 82.1 ± 1% relative density via controlled dissolution-reprecipitation mechanisms. Heckel analysis reveals yield pressures (P_y) = 10.93-12.20 MPa (R² > 0.97), confirming a nonlinear deformation behavior. Hierarchical porosity is successfully maintained (BET surface area = 559.11 m² g^-1; micropore volume = 0.28 cm³ g^-1). NaOH-assisted CSP (5 M NaOH, 25 wt.%, 350 MPa, 200 °C, 60 min, 5 °C min^-1) achieves exceptional densification of 99.1 ± 0.5% (geometric) and 98.7 ± 0.5% (Archimedes) relative density. Enhanced nonlinear densification is evidenced by reduced P_y values (1.77-2.17 MPa, R² > 0.98). Despite near-theoretical densification, intrinsic porosity remains intact (BET = 422.01 m² g^-1; micropore volume = 0.21 cm³ g^-1). Statistical ANOVA analysis confirms excellent reproducibility (F < 1 × 10^-5, p = 0.99) and significant pressure dependency. Both pathways preserve crystallographic integrity and thermal stability to 800 °C, achieving ≈80-90% energy reduction compared to conventional sintering, demonstrating CSP’s potential for sustainable ceramic processing.

PMID:41251045 | DOI:10.1002/smll.202509928