Arch Dermatol Res. 2024 Jun 8;316(7):371. doi: 10.1007/s00403-024-03086-x.
NO ABSTRACT
PMID:38850422 | DOI:10.1007/s00403-024-03086-x
Category: Nevin Manimala
Arch Dermatol Res. 2024 Jun 8;316(7):377. doi: 10.1007/s00403-024-03015-y.
NO ABSTRACT
PMID:38850418 | DOI:10.1007/s00403-024-03015-y
Arch Dermatol Res. 2024 Jun 8;316(7):376. doi: 10.1007/s00403-024-03025-w.
NO ABSTRACT
PMID:38850413 | DOI:10.1007/s00403-024-03025-w
Arch Dermatol Res. 2024 Jun 8;316(7):370. doi: 10.1007/s00403-024-03067-0.
NO ABSTRACT
PMID:38850410 | DOI:10.1007/s00403-024-03067-0
Arch Dermatol Res. 2024 Jun 8;316(7):350. doi: 10.1007/s00403-024-03054-5.
ABSTRACT
Loss and absence of melanocytes due to a number of factors is responsible for vitiligo; known to be the commonest disorder of pigmentation. The aim of the current work was to compare the efficacy and safety of excimer light with topical tacrolimus ointment 0.1% versus excimer light with topical bimatoprost gel 0.01% in treatment of facial vitiligo. The study was carried out on 48 patients presented with facial vitiligo. The patients were divided randomly using sealed envelope method into two groups (24 patients each). Group 1 were treated with excimer light plus topical tacrolimus ointment 0.1% and group 2 treated with excimer light plus topical bimatoprost gel 0.01%. Clinical improvement based on the quartile grading scale at the end of treatment did not show any statistically significant difference between groups. The majority of subjects in both groups experienced good to excellent improvement. Only 20.9% of patients in group 1 and 33.3% of subjects in group 2 achieved less than 50% repigmentation (p = 0.889). Our study demonstrated that 0.01% topical bimatoprost gel in combination with excimer light is considered safe and effective as treatment of nonsegmental facial vitiligo with comparable results to 0.1% tacrolimus.
PMID:38850408 | DOI:10.1007/s00403-024-03054-5
Arch Dermatol Res. 2024 Jun 8;316(7):372. doi: 10.1007/s00403-024-03101-1.
ABSTRACT
Occupational dermatoses impose a significant socioeconomic burden. Allergic contact dermatitis related to occupation is prevalent among healthcare workers, cleaning service personnel, individuals in the beauty industry and industrial workers. Among risk factors, the exposure to preservatives is frequent, since they are extensively added in products for occupational use. The goal of this study is to investigate the contact allergy patterns in order to understand the linkage among hypersensitivity to preservatives, occupational profiles, patients’ clinical and demographic characteristics. Patch test results were collected from monosensitized patients to Formaldehyde 2%, KATHON 0.02%, thimerosal 0.1%, and MDBGN 0.5%; information was also collected for an extended MOAHLFA (Male-Occupational-Atopic-Hand-Leg-Face-Age) index. To assess the relationship between allergen group and occupational-related ACD, the chi-square test for independence was utilized. To uncover underlying relationships in the data, multiple correspondence analysis (MCA) and categorical principal components analysis (CATPCA), which are machine learning approaches, were applied. Significant relationships were found between allergen group and: occupation class, atopy, hand, leg, facial, trunk, neck, head dermatitis, clinical characteristics, ICDRG 48 h and ICDRG 72 h clinical evaluation. MCA and CATPCA findings revealed a link among allergen group, occupation class, patients’ demographic and clinical characteristics, the MOAHLFA index, and the ICDRG scores. Significant relationships were identified between the allergen group and various manifestations of dermatitis. The utilization of machine learning techniques facilitated the discernment of meaningful patterns in the data.
PMID:38850385 | DOI:10.1007/s00403-024-03101-1
Clin Oral Investig. 2024 Jun 8;28(7):366. doi: 10.1007/s00784-024-05765-5.
ABSTRACT
OBJECTIVES: This study examined the impact of premedication with ibuprofen and ibuprofen-arginine and the influence of preoperative pain and anxiety on inferior alveolar nerve block (IANB) efficacy in cases of symptomatic irreversible pulpitis.
MATERIALS AND METHODS: The study involved 150 SIP patients who were randomly assigned to receive ibuprofen (600 mg), ibuprofen-arginine (1,155 mg), or a placebo 30 min before IANB. Preoperative anxiety and pain levels were assessed using the Modified Dental Anxiety Scale and the Heft-Parker visual scale. IANB efficacy was determined by the absence of or mild pain during the procedure. Statistical analysis included chi-square, z-tests, Analysis of Variance, and Student’s t tests.
RESULTS: The ibuprofen and ibuprofen-arginine groups exhibited significantly higher IANB success rates (62% and 78%, respectively) compared to the placebo group (34%). However, no significant difference was observed between the ibuprofen and ibuprofen-arginine groups. Patients with successful IANB in the ibuprofen and ibuprofen-arginine groups displayed lower median anxiety scores (8) than those with failed blocks (15) and lower mean preoperative pain scores (118.3).
CONCLUSION: In cases of symptomatic irreversible pulpitis the preemptive medication with ibuprofen-arginine effectively increased the efficacy of the inferior alveolar nerve block The inferior alveolar nerve block efficacy was influenced by preoperative anxiety levels and the intensity of pain.
CLINICAL RELEVANCE: This research underscores the potential benefits of oral premedication with ibuprofen and ibuprofen-arginine in improving anesthesia outcomes in cases of symptomatic irreversible pulpitis.
PMID:38850383 | DOI:10.1007/s00784-024-05765-5
J Robot Surg. 2024 Jun 8;18(1):247. doi: 10.1007/s11701-024-01980-0.
ABSTRACT
Long-term postoperative complications of metabolic and bariatric surgery (MBS) are more frequent than those of primary surgery. Robotic-assisted procedures offer several advantages over traditional laparoscopy, but there are limited data. A retrospective study of 29 patients who underwent a revisional robotic-assisted Roux-en-Y gastric bypass (RRYGB) in a Tertiary Level Hospital. Variables included were demographics, causes for revision, operative details, complications, and weight loss outcomes up to 54 month post-RRYGB. Causes for conversion were weight loss failure (WLF), weight regain (WR), Gastroesophageal Reflux Disease (GERD), or Joint Pain (JP). We assessed 29 patients. Causes for conversion included WLF (34%), WR (15%), WR with GERD (20%), GERD (24%), and JP (3%). Initial BMI was 53.43 kg/m2 ± 8.75. Mean length of hospital stay (LOS) was 2 days. Total operative time was 126 min. ± 43.45. Excess weight loss at 1 year post-surgery was 82.66% (p < 0.0001), with mean BMI of 30.93 kg/m2 (p < 0.001). At 3 years, mean %EWL was 71.26% and a mean BMI 33.81 kg/m2 (p < 0.0001). At 4.5 years, mean %EWL was 59.29% and mean BMI 37.27 kg/m2 (p < 0.0001). One complication (8%) was found (jejunojejunal stenosis). There was no mortality. The initial experience with RRYGB shows acceptable outcomes, including low morbidity, no mortality, excellent weight loss after the revisional surgery, and promising reduction in operative times, with important implications on reduction of the total cost of the procedure.
PMID:38850381 | DOI:10.1007/s11701-024-01980-0
Environ Monit Assess. 2024 Jun 8;196(7):603. doi: 10.1007/s10661-024-12762-4.
ABSTRACT
Ground-level ozone (O3) pollution has emerged as a significant concern impacting air quality in urban agglomerations, primarily driven by meteorological conditions and social-economic factors. However, previous studies have neglected to comprehensively reveal the spatial distribution and driving mechanism of O3 pollution. Based on the O3 monitoring data of 41 cities in the Yangtze River Delta (YRD) from 2014 to 2021, a comprehensive analysis framework of spatial analysis-spatial econometric regression was constructed to reveal the driving mechanism of O3 pollution. The results revealed the following: (1) O3 concentrations in the YRD exhibited a general increasing and then decreasing trend, indicating an improvement in pollution levels. The areas with higher O3 concentration are mainly the cities concentrated in central and southern Jiangsu, Shanghai, and northern Zhejiang. (2) The change of O3 concentration and distribution is the result of various factors. The effect of urbanization on O3 concentrations followed an inverted U-shaped curve, which implies that achieving higher quality urbanization is essential for effectively controlling urban O3 pollution. Traffic conditions and energy consumption have significant direct positive influences on O3 concentrations and spatial spillover effects. The indirect pollution contribution, considering economic weight, accounted for about 35%. Thus, addressing overall regional energy consumption and implementing traffic source regulations are crucial paths for O3 pollution control in the YRD. (3) Meteorological conditions play a certain role in regulating the O3 concentration. Higher wind speed will promote the diffusion of O3 and increase the O3 concentration in the surrounding city. These findings provide valuable insights for designing effective policies to improve air quality and mitigate ozone pollution in urban agglomeration area.
PMID:38850374 | DOI:10.1007/s10661-024-12762-4
Indian J Pediatr. 2024 Jun 8. doi: 10.1007/s12098-024-05165-3. Online ahead of print.
ABSTRACT
OBJECTIVES: To evaluate the effect of antiepileptic medications prescribed to mothers during pregnancy on the development and behavior of children.
METHODS: From the Kerala Registry of Epilepsy and Pregnancy, 98 children between the ages of 1½ to 2½ y were consecutively chosen. Children of mothers who did not have epilepsy during pregnancy and not exposed to antiseizure medications (ASMs) antenatally were selected as comparator group. Developmental assessment of the children was performed using Developmental Assessment Scale for Indian Infants (DASII) and Receptive-Expressive Emergent Language Scale (REELS). Behavior outcomes were assessed using Child Behavior Checklist.
RESULTS: A significant delay in expressive language skills was seen in children exposed to antiseizure medication with an odds ratio of 2.539 (95% CI 1.10, 5.85, P = 0.026). A delay in expressive language skills was seen in polytherapy with clobazam (odds ratio 6.83; 95% CI 2.17, 21.56, P < 0.001). Also, delay was seen in receptive language skills in the same polytherapy group (odds ratio of 7.333; 95% CI 2.16, 24.92, P < 0.001). There were no statistically significant differences between study and comparative groups in motor and mental quotient domains and behavioral outcomes.
CONCLUSIONS: The finding of speech delay in children exposed to ASMs is significant since individuals with a history of childhood speech or language disorders may experience long-term difficulties in mental health, social well-being, and academic outcomes.
PMID:38850358 | DOI:10.1007/s12098-024-05165-3