Category: Nevin Manimala

J Adv Res. 2024 May 24:S2090-1232(24)00214-5. doi: 10.1016/j.jare.2024.05.025. Online ahead of print.

ABSTRACT

INTRODUCTION: Residential greenness may influence COPD mortality, but the causal links, risk trajectories, and mediation pathways between them remain poorly understood.

OBJECTIVES: We aim to comprehensively identify the potential causal links, characterize the dynamic progression of hospitalization or posthospital risk, and quantify mediation effects between greenness and COPD.

METHODS: This study was conducted using a community-based cohort enrolling individuals aged ≥ 18 years in southern China from January 1, 2009 to December 31, 2015. Greenness was characterized by normalized difference vegetation index (NDVI) around participants’ residential addresses. We applied doubly robust Cox proportional hazards model, multi-state model, and multiple mediation method, to investigate the potential causal links, risk trajectories among baseline, COPD hospitalization, first readmission due to COPD or COPD-related complications, and all-cause death, as well as the multiple mediation pathways (particulate matter [PM], temperature, body mass index [BMI] and physical activity) connecting greenness exposure to COPD mortality.

RESULTS: Our final analysis included 581,785 participants (52.52% female. average age: 48.36 [Standard Deviation (SD): 17.56]). Each interquartile range (IQR: 0.06) increase in NDVI was associated with a reduced COPD mortality risk, yielding a hazard ratio (HR) of 0.88 (95 % CI: 0.81, 0.96). Furthermore, we observed per IQR (0.04) increase in NDVI was inversely associated with the risk of multiple transitions (baseline – COPD hospitalization, baseline – death, and readmission – death risks), especially a declined risk of all-cause death after readmission (HR = 0.66 [95 %CI: 0.44, 0.99]). Within the observed association between greenness and COPD mortality, three mediators were identified, namely PM, temperature, and BMI (HR for the total indirect effect: 0.773 [95 % CI: 0.703, 0.851]), with PM showing the highest mediating effect.

CONCLUSIONS: Our findings revealed greenness may be a beneficial factor for COPD morbidity, prognosis, and mortality. This protective effect is primarily attributed to the reduction in PM concentration.

PMID:38797475 | DOI:10.1016/j.jare.2024.05.025

Math Biosci. 2024 May 24:109220. doi: 10.1016/j.mbs.2024.109220. Online ahead of print.

ABSTRACT

Ecological balance and stable economic development are crucial for the fishery. This study proposes a predator-prey system for marine communities, where the growth of predators follows the Allee effect and takes into account the rapid fluctuations in resource prices caused by supply and demand. The system predicts the existence of catastrophic equilibrium, which may lead to the extinction of prey, consequently leading to the extinction of predators, but fishing efforts remain high. Marine protected areas are established near fishing areas to avoid such situations. Fish migrate rapidly between these two areas and are only harvested in the nonprotected areas. A three-dimensional simplified model is derived by applying variable aggregation to describe the variation of global variables on a slow time scale. To seek conditions to avoid species extinction and maintain sustainable fishing activities, the existence of positive equilibrium points and their local stability are explored based on the simplified model. Moreover, the long-term impact of establishing marine protected areas and levying taxes based on unit catch on fishery dynamics is studied, and the optimal tax policy is obtained by applying Pontryagin’s maximum principle. The theoretical analysis and numerical examples of this study demonstrate the comprehensive effectiveness of increasing the proportion of marine protected areas and controlling taxes on the sustainable development of fishery.

PMID:38797471 | DOI:10.1016/j.mbs.2024.109220

J Shoulder Elbow Surg. 2024 May 24:S1058-2746(24)00355-0. doi: 10.1016/j.jse.2024.03.056. Online ahead of print.

ABSTRACT

BACKGROUND: Rotator cuff tears are a common orthopedic injury and the role of social determinants of health (SDoH) in surgical outcomes remains underexplored. The goal of this study was to investigate the correlation between social deprivation, measured by the Area Deprivation Index (ADI), and outcomes following arthroscopic rotator cuff repair.

METHODS: We conducted a retrospective chart review on patients undergoing primary arthroscopic rotator cuff repair at a level one academic center between 2006 and 2019. Patient demographics (age, gender, race), comorbidities, ADI scores, range of motion, visual analog pain scores, and patient-reported outcomes (SST, ASES, and QuickDASH) were collected. Patients were stratified into terciles based on their relative level of deprivation. Statistical analysis was performed using ANOVA, t-tests, chi-square tests, and univariate/multivariate logistic regression.

RESULTS: 322 patients were included in this study. The most deprived group had a higher prevalence of diabetes compared to the least and intermediately deprived group (p<0.001). Massive tear occurrence was greater in the least deprived group (p=0.003) compared to the most deprived group. There was no difference in objective outcomes between groups. Patient-reported outcomes (SST, ASES, and QuickDASH) were worse in the most deprived group compared to the least and intermediate deprived groups.

CONCLUSION: Social deprivation significantly affects patient-reported outcomes in rotator cuff repair surgery. While clinician-reported outcomes were consistent, patients’ perceptions varied based on social determinants. Integrating SDoH considerations in orthopedic care is a promising next step in securing equitable approaches. However, more research is needed to validate and expand these findings.

PMID:38797469 | DOI:10.1016/j.jse.2024.03.056

J Arthroplasty. 2024 May 24:S0883-5403(24)00525-4. doi: 10.1016/j.arth.2024.05.053. Online ahead of print.

ABSTRACT

INTRODUCTION: Venous thromboembolism (VTE) poses a major clinical concern due to its life-threatening nature, and obese and morbidly obese patients are thought to be at an increased risk for VTE. The aims of this study were twofold; first, to explore VTE rates in patients who have a body mass index > 40 undergoing primary and revision total joint arthroplasty (TJA), and second, to investigate aspirin (ASA) efficacy and safety.

METHODS: We identified all patients (n = 4,672) who had a BMI > 40 who underwent primary and revision TJA from 2016 to 2022 at a single academic tertiary care center. Patients were stratified by BMI groups: 40 to 44.9 (n = 3,462), 45 to 49.9 (n = 935), and 50+ (n = 275). The primary outcome was any venous thromboembolism (VTE) event within 90 days postoperatively. The secondary outcome consisted of wound complications within 90 days postoperatively.

RESULTS: The total VTE rate was 0.4% (n = 21) and did not differ statistically between the BMI groups (0.4 versus 0.4 versus 0.7%, P = 0.669). The VTEs consisted of six deep venous thromboses (DVT), fourteen pulmonary embolisms (PE), and one concomitant DVT and PE. The VTE rates were not statistically different between patients who received aspirin 325 mg 0.5% (n = 9), aspirin 81 mg 0.2% (n = 1), aspirin + anticoagulant 0.5% (n = 6), and anticoagulant alone 0.4% (n = 5) (P = 0.954). In addition, wound complications did not differ significantly between patients who received ASA 325 mg, ASA 81mg, ASA + anticoagulant, or anticoagulant alone (1.6 versus 1.0 versus 1.8 versus 1.1%, P = 0.351).

CONCLUSION: The use of aspirin 325 mg and 81 mg was found to have similar VTE rates as aspirin + anticoagulants and anticoagulants alone, with no significant increase in wound complications. In patients who have a BMI > 40, the use of aspirin is a safe option for VTE prophylaxis and should be prescribed in the context of the patient who has other risk factors for VTE.

PMID:38797448 | DOI:10.1016/j.arth.2024.05.053

Sci Total Environ. 2024 May 24:173524. doi: 10.1016/j.scitotenv.2024.173524. Online ahead of print.

ABSTRACT

Understanding the relationships among ecosystem services (ESs) and their interactions with influencing factors is essential for spatially targeted ecosystem governance. However, classifying the spatial distribution of these diverse interactions still needs improvement. Furthermore, existing studies have insufficiently addressed the specific impacts of bidirectional land cover transitions on ESs. Taking the upper Blue Nile basin as a study area, we estimated the spatiotemporal distribution of annual water yield (AWY), carbon storage (CS), habitat quality (HQ), and soil retention (SR) from 2000 to 2020, using InVEST models and associated formulas. Changes in ESs per inward-outward land cover transition were quantified based on the Cross-Tabulation Matrix. An improved pairwise method was employed to assess the spatially diverse interactions between ESs pairs and their relationship with influencing factors. The statistical significance of influencing factors was evaluated using partial least square regression. The findings indicated that high HQ values were prevalent in the west, while they were in the east for SR. The central and southern areas experienced higher CS and AWY values. During the study period, variations were observed in the mean values of SR (ranging from 22.89 to 23.88 × 10² t/ha/y), AWY (32.13-42.2 × 10² mm/ha/y), CS (90.5-102.9 × 10³gC/ha/y) and HQ (0.62-0.64). Synergies were predominant in AWY-CS, AWY-SR, and CS-SR pairs. HQ revealed more of a no-effect and tradeoff relationship with other ESs. The interactions between ESs and influencing factors were dominated by synergies, followed by tradeoffs and no-effect. The influence of landscape structure (gyrate and landscape shape index) and land surface temperature on all ESs and precipitation on AWY and SR was significant (1.049 ≤ Variable Importance in the Projection ≤ 1.371). Overall, the spatiotemporal dynamics of key ESs and the modeling of their drivers are essential policy information for taking spatially explicit conservation measures. This study will also serve as a valuable methodological reference for future research.

PMID:38797426 | DOI:10.1016/j.scitotenv.2024.173524

Sci Total Environ. 2024 May 24:173337. doi: 10.1016/j.scitotenv.2024.173337. Online ahead of print.

ABSTRACT

The intricate oceanic climate interactions with terrestrial primary production of Asian ecosystems exert crucial social-economical-environmental repercussions. Yet, a holistic understanding of tropical sea surface temperature (SST) anomalies associated with the gross primary productivity (GPP) variations of monsoon-Asia remains constrained. This study provides a statistical framework demonstrating how SST perturbations in the tropics influence GPP fluctuations in monsoon-Asia by modulating hydrothermal conditions of different climate system components. Observation evidence explicitly illustrated the characteristic anomalous SST signatures of positive and negative GPP anomalies in South and Southeast Asia during June-August. The SST anomalies of the central-eastern tropical Pacific showed a robust negative impact on the GPP variability of South-Asia. The GPP alterations in maritime-Southeast-Asia exhibited strong connections with SST anomalies of the western Pacific (positive) and eastern equatorial Pacific (negative). The oceanic signals in the GPP variability of South-Asia and maritime-Southeast-Asia mirrored canonical El Niño and La Niña patterns. The detected SST-GPP link is feasible through large-scale atmospheric circulation variability and the consequent regional modulation of heat and moisture fluxes. The anomalous strengthening (weakening) of Walker cell enhance (reduce) water available to plants for photosynthesis during La Niña (El Niño) phase of ENSO cycle and thus elevate (lower) GPP in South-Asia and Maritime-southeast-Asia. In contrast, the enhanced GPP anomaly in mainland-Southeast-Asia depicts signs of canonical La Niña and Indian Ocean subtropical dipole (IOSD) teleconnections. The positive impact of IOSD was through the modulation of the Mascarene High and the consequent impact on monsoon. Meanwhile, decreased GPP bears the imprint of El Niño Modoki and warm tropical Indian Ocean SSTs. The atmospheric teleconnections demonstrated the delayed impact of El Niño Modoki on GPP variability through the Indian Ocean capacitor effect. Our findings could be instrumental in forecasting the probable effects on vegetation growth in monsoon-Asia associated with high-frequency tropical oceanic changes.

PMID:38797406 | DOI:10.1016/j.scitotenv.2024.173337

J Affect Disord. 2024 May 24:S0165-0327(24)00824-3. doi: 10.1016/j.jad.2024.05.088. Online ahead of print.

ABSTRACT

BACKGROUND: High rates of depression and suicidal ideation are found in women experiencing intimate partner violence (IPV), but their temporal relationship is unclear. This study explores the bidirectional causality between IPV victimization, depressive symptoms, and suicidal thoughts among adolescent and young married women in India.

METHODS: Data sourced from the UDAYA longitudinal survey in India, comprising 3965 women aged 15-22. Employing Pearson’s correlation coefficient, we analyzed the relationship between variables. Additionally, a two-wave cross-lagged autoregressive panel model explored the bidirectional link between IPV, depressive symptoms, and suicidal ideation.

RESULTS: Approximately 25 % and 45 % of the participants reported some form of partner violence at baseline and at follow-up after three years, respectively. Exposure to IPV at baseline was significantly associated with depressive symptoms at follow-up [β = 0.10, p < 0.001], and the association between depressive symptoms at baseline and IPV at follow-up was statistically not significant [β = -0.02, 95 % CI: -0.06-0.02]. Similarly, exposure to IPV at baseline was significantly associated with suicidal thoughts at follow-up [β = 0.24, p < 0.001], and the association between suicidal thoughts at baseline and IPV at follow-up was statistically not significant [β = 0.003, 95 % CI: -0.001-006].

CONCLUSIONS: The findings suggest that exposure to IPV is consistently and strongly associated with depressive symptoms and suicidal thoughts in adolescent and young married women. However, the reciprocal relationships did not hold true in this study, implying that reducing IPV during adolescence could potentially minimize the prevalence of depressive symptoms and suicidal thoughts during young adulthood.

PMID:38797392 | DOI:10.1016/j.jad.2024.05.088

J Affect Disord. 2024 May 24:S0165-0327(24)00863-2. doi: 10.1016/j.jad.2024.05.120. Online ahead of print.

ABSTRACT

BACKGROUND: Depression is common at older ages, but is under-recognized due to stigma, misperception, and under-diagnosis; its manifestations may vary by setting. Identifying older adults at risk of depression in the community is urgently needed for timely support and early interventions. We assessed the performance of an existing risk prediction model developed in a European setting (i.e., Depression Risk Assessment Tool (DRAT-up)), and developed a new model (i.e., EHS-Depress model) to predict 2-year risk of the onset of later life depressive symptoms in older Chinese adults.

METHODS: Among 185,538 participants aged ≥65 years from Hong Kong’s Elderly Health Service (EHS) cohort, 174,806 without depressive symptoms at baseline were included. Two-thirds were randomly sampled for recalibration and new model development using Cox proportional-hazards models with backward elimination. Overall predictive performance, discrimination, and calibration were assessed using the remaining.

RESULTS: The original DRAT-up model underestimated the risk of developing depressive symptoms in older Chinese adults; recalibrating it improved calibration. The new EHS-Depress mode had better discrimination (Harrell’s C statistic 0.68 and D statistic 2.74) and similarly good calibration (calibration slope 1.18 and intercept -0.002) probably due to the inclusion of more specific health measures, socio-demographics, lifestyle factors, and regular social contact as predictors.

LIMITATIONS: Predictors of depressive symptoms included in our models depend on the data availability.

CONCLUSIONS: The EHS-Depress model predicted 2-year risk of developing depressive symptoms better than the original and recalibrated DRAT-up models. The setting-specific risk prediction model is more applicable to older Chinese adults in primary care settings.

PMID:38797391 | DOI:10.1016/j.jad.2024.05.120

Acta Otorrinolaringol Esp (Engl Ed). 2024 May 24:S2173-5735(24)00062-0. doi: 10.1016/j.otoeng.2024.05.002. Online ahead of print.

ABSTRACT

BACKGROUND AND OBJECTIVE: Sound localization plays a crucial role in our daily lives, enabling us to recognize voices, respond to alarming situations, avoid dangers, and navigate towards specific signals. However, this ability is compromised in patients with Single-Sided Deafness (SSD) and Asymmetric Hearing Loss (AHL), negatively impacting their daily functioning. The main objective of the study was to quantify the degree of sound source localization in patients with single-sided deafness or asymmetric hearing loss using a Cochlear Implant (CI) and to compare between the two subgroups.

MATERIALS AND METHODS: This was a prospective, longitudinal, observational, single-center study involving adult patients diagnosed with profound unilateral or asymmetric sensorineural hearing loss who underwent cochlear implantation. Sound localization was assessed in a chamber equipped with seven speakers evenly distributed from -90º to 90º. Stimuli were presented at 1000 Hz and intensities of 65 dB, 70 dB, and 75 dB. Each stimulus was presented only once per speaker, totaling 21 presentations. The number of correct responses at different intensities was recorded, and angular error in degrees was calculated to determine the mean angular distance between the patient-indicated speaker and the speaker presenting the stimulus. Both assessments were conducted preoperatively without a cochlear implant and two years post-implantation.

RESULTS: The total sample comprised 20 patients, with 9 assigned to the SSD group and 11 to the AHL group. The Preoperative Pure Tone Average (PTA) in free field was 31.7 dB in the SSD group and 41.8 dB in the AHL group. There was a statistically significant improvement in sound localization ability and angular error with the use of the cochlear implant at all intensities in both SSD and AHL subgroups.

CONCLUSIONS: Cochlear implantation in patients with SSD and AHL enhances sound localization, reducing mean angular error and increasing the number of correct sound localization responses.

PMID:38797372 | DOI:10.1016/j.otoeng.2024.05.002

Otolaryngol Head Neck Surg. 2024 May 26. doi: 10.1002/ohn.824. Online ahead of print.

ABSTRACT

OBJECTIVE: Whether ligation or reconstruction should be performed after radical resection of the tumor and carotid artery in patients with head and neck cancers invading the carotid artery (HNC-CA) has been controversial. This paper provides a review and meta-analysis of the efficacy of these 2 modalities.

DATA SOURCES: PubMed, Cochrane, Web of Science, Scopus, and Ovid databases were searched through August 2023.

REVIEW METHODS: Descriptive, graphical, tabular, and quantitative data were extracted. The statistical outcomes (risk difference, RD) were synthesized under a random-effects model. This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses reporting guidelines.

RESULTS: A total of 22 papers and 337 patients met the inclusion criteria for the literature review. Statistical analysis showed that the RD of overall survival (OS) rate at 1-year was 32% (95% confidence interval [CI]: 21%-42%) for ligation and 70% (95% CI: 65%-76%) for reconstruction (P < .05). The RD for OS rate at 2-year was 16% (95% CI: 7%-26%) for ligation and 39% (95% CI: 30%-47%) for reconstruction (P < .05). The RD for disease-free survival rate at 1-year was 27% (95% CI: 17%-38%) for ligation and 60% (95% CI: 51%-70%) for reconstruction (P < .05). There were no statistically significant differences (P > .05) between the 2 surgical modalities in terms of locoregional recurrence rate, carotid blowout rate, surgery-related complications rate, neurological complications rate, and perioperative mortality rate.

CONCLUSION: This review demonstrates the significant advantage of carotid artery reconstruction surgery in short-term patient survival, thus making it a recommended option for HNC-CA patients undergoing radical surgery.

PMID:38796730 | DOI:10.1002/ohn.824