Category: Nevin Manimala

J Orthop Surg Res. 2023 Dec 9;18(1):946. doi: 10.1186/s13018-023-04438-5.

ABSTRACT

BACKGROUND: Triangular fibrocartilage complex (TFCC) injury is a frequent soft tissue injury that has been observed to accompany distal radius fractures (DRFs) with concomitant changes in radiologic parameters. The aim of this study was to investigate the relevance of distal radial radiologic parameters associated with DRF and traumatic TFCC injury.

METHODS: A total of 172 patients with distal radius fractures who underwent X-ray, CT, and MRI before undergoing volar locking plate or external splint fixation between October 2021 and December 2022 were included in this study. An analysis of various radiologic parameters and the classification of fracture type and TFCC injuries by CT and MRI was performed. All patients were divided into the TFCC uninjured group and the injured group. The incidence and relevant radiologic parameters were compared.

RESULTS: This study included 76 males and 96 females with a mean age of 56.1 years. Among all patients, 33 (19.2%), 40 (23.2%), and 99 (57.6%) had DRF with A, B, and C fractures, respectively, according to the AO/OTA classification. In patients with fractures, the TFCC was found to be injured in 54.1% (93/172) of patients (type 1A in 21, 1B in 46, 1C in 39, and 1D in 35) but uninjured in 45.9% (79/172). There were significant differences between the TFCC injured and uninjured groups regarding the radius length (p = 0.044) and DRUJ distance (p = 0.040) of radiologic parameters that changed with DRF, although there were no differences between the two groups regarding gender, age, injured side, intra- and extra-articular, radius inclination and palmer tilt angle, or sagittal translation. Within the TFCC injured group, the radius length and DRUJ distance were 4.83 mm and 2.95 mm less or wider than 7.19 mm and 1.83 mm of the uninjured group. Moreover, shorter radius length was related to type lB TFCC injury (p = 0.041). Both radius length (AUC = 0.658) and DRUJ distance (AUC = 0.582) had no convincing predictive value for TFCC injury in DRF.

CONCLUSION: 1B TFCC injury is most common in patients with DRF and concomitant TFCC injury. Both radius length and DRUJ distance have a significant statistical correlation with TFCC injury, and patients with TFCC injury tend to have a shortened radius and wider DRUJ distance, although they have no predictive value for TFCC injury in DRF. In addition, a shorter radius length was related to type lB TFCC injury.

PMID:38071283 | DOI:10.1186/s13018-023-04438-5

Sci Rep. 2023 Dec 9;13(1):21812. doi: 10.1038/s41598-023-49143-9.

ABSTRACT

Bicycles are an eco-friendly mode of transportation, and in the capital city of South Korea, Seoul, efforts are being made to encourage citizens to use bicycles. However, without appropriate safety measures, these efforts can lead to an increase in bicycle-related traffic accidents. To promote bicycle usage while ensuring safety, this study identified various factors that influence bicycle accidents. Data were utilized that had not been properly considered in previous bicycle accident-related studies, including slope and the level of public transportation services. By considering the factors influencing bicycle traffic accidents, various models were constructed, and through comparisons of statistical indicators, the optimal model was selected geographically weighted negative binomial regression. Ultimately, three significant conclusions to ensure bicycle safety were drawn. First, across all areas of Seoul, an increase in road slope leads to a decrease in bicycle-related accidents. Furthermore, for certain Traffic Analysis Zones (TAZs), as the number of local buses (or neighborhood/community buses) increases, the bicycle traffic volume decreases, resulting in a reduction in bicycle accidents. Lastly, for some TAZs, an increase in bicycle lanes to be installed into the roadway was associated with an increase in bicycle accidents.

PMID:38071264 | DOI:10.1038/s41598-023-49143-9

Sci Rep. 2023 Dec 9;13(1):21849. doi: 10.1038/s41598-023-49159-1.

ABSTRACT

Early detection of prostate cancer (PCa) and benign prostatic hyperplasia (BPH) is crucial for maintaining the health and well-being of aging male populations. This study aims to evaluate the performance of transfer learning with convolutional neural networks (CNNs) for efficient classification of PCa and BPH in transrectal ultrasound (TRUS) images. A retrospective experimental design was employed in this study, with 1380 TRUS images for PCa and 1530 for BPH. Seven state-of-the-art deep learning (DL) methods were employed as classifiers with transfer learning applied to popular CNN architectures. Performance indices, including sensitivity, specificity, accuracy, positive predictive value (PPV), negative predictive value (NPV), Kappa value, and Hindex (Youden’s index), were used to assess the feasibility and efficacy of the CNN methods. The CNN methods with transfer learning demonstrated a high classification performance for TRUS images, with all accuracy, specificity, sensitivity, PPV, NPV, Kappa, and Hindex values surpassing 0.9400. The optimal accuracy, sensitivity, and specificity reached 0.9987, 0.9980, and 0.9980, respectively, as evaluated using twofold cross-validation. The investigated CNN methods with transfer learning showcased their efficiency and ability for the classification of PCa and BPH in TRUS images. Notably, the EfficientNetV2 with transfer learning displayed a high degree of effectiveness in distinguishing between PCa and BPH, making it a promising tool for future diagnostic applications.

PMID:38071254 | DOI:10.1038/s41598-023-49159-1

Nat Commun. 2023 Dec 9;14(1):8177. doi: 10.1038/s41467-023-44031-2.

ABSTRACT

Counteracting the overactivation of glucocorticoid receptors (GR) is an important therapeutic goal in stress-related psychiatry and beyond. The only clinically approved GR antagonist lacks selectivity and induces unwanted side effects. To complement existing tools of small-molecule-based inhibitors, we present a highly potent, catalytically-driven GR degrader, KH-103, based on proteolysis-targeting chimera technology. This selective degrader enables immediate and reversible GR depletion that is independent of genetic manipulation and circumvents transcriptional adaptations to inhibition. KH-103 achieves passive inhibition, preventing agonistic induction of gene expression, and significantly averts the GR’s genomic effects compared to two currently available inhibitors. Application in primary-neuron cultures revealed the dependency of a glucocorticoid-induced increase in spontaneous calcium activity on GR. Finally, we present a proof of concept for application in vivo. KH-103 opens opportunities for a more lucid interpretation of GR functions with translational potential.

PMID:38071198 | DOI:10.1038/s41467-023-44031-2

Sci Rep. 2023 Dec 9;13(1):21855. doi: 10.1038/s41598-023-49029-w.

ABSTRACT

In this paper, we aim to present a powerful approach for the approximate results of multi-dimensional diffusion problems with time-fractional derivatives. The fractional order is considered in the view of the Caputo fractional derivative. In this analysis, we develop the idea of the Yang homotopy perturbation transform method (YHPTM), which is the combination of the Yang transform (YT) and the homotopy perturbation method (HPM). This robust scheme generates the solution in a series form that converges to the exact results after a few iterations. We show the graphical visuals in two-dimensional and three-dimensional to provide the accuracy of our developed scheme. Furthermore, we compute the graphical error to demonstrate the close-form analytical solution in the comparison of the exact solution. The obtained findings are promising and suitable for the solution of multi-dimensional diffusion problems with time-fractional derivatives. The main advantage is that our developed scheme does not require assumptions or restrictions on variables that ruin the actual problem. This scheme plays a significant role in finding the solution and overcoming the restriction of variables that may cause difficulty in modeling the problem.

PMID:38071195 | DOI:10.1038/s41598-023-49029-w

Dig Liver Dis. 2023 Dec 8:S1590-8658(23)01071-X. doi: 10.1016/j.dld.2023.11.030. Online ahead of print.

ABSTRACT

BACKGROUND AND AIMS: Despite its growing popularity, endoscopic submucosal dissection (ESD) for colorectal neoplasms is still technically challenging. The factors contributing to the failure of ESD are not yet comprehensively elucidated. Therefore, this systematic review was conducted to explore the potential risk factors associated with unsuccessful colorectal ESD.

METHODS: A comprehensive search of Medline and Embase databases was conducted to identify relevant publications from inception until March 14, 2023. Unsuccessful ESD was defined as cases involving incomplete resection or the occurrence of adverse events, such as perforation and delayed bleeding.

RESULTS: Among the 2067 citations initially identified, a total of 23 cohort studies and 16 case-control studies met the inclusion criteria. Following meta-analyses, several significant risk factors for incomplete resection were identified, including lesion diameter ≥40 or 50 mm, right-side colonic location, deeper submucosal invasion, and severe fibrosis. Similarly, lesion diameter ≥40 or 50 mm and severe fibrosis emerged as risk factors for perforation. However, no individual factor was found to be statistically associated with delayed bleeding.

CONCLUSIONS: This meta-analysis identified risk factors correlated with incomplete resection and adverse events following ESD. The findings provide valuable insights that can guide clinical decision-making, aiding gastroenterologists in accurately identifying high-risk individuals.

PMID:38071178 | DOI:10.1016/j.dld.2023.11.030

Endeavour. 2023 Dec 8:100902. doi: 10.1016/j.endeavour.2023.100902. Online ahead of print.

ABSTRACT

Although much scholarship on nineteenth and twentieth century mathematics has focused on processes of professionalization, historical mathematicians themselves rarely experienced their lives as neatly divisible into the professional and the private. Taking marriage as a focal point, this introduction brings the fruitful historiography of gender, collaborative couples, and domesticity in science into a broader conversation with the history of mathematics. By historicizing marriage and its relationship to mathematical careers, we lay the groundwork for the special issue which uncovers the myriad ways in which spousal collaboration and support have been central to mathematical work.

PMID:38071174 | DOI:10.1016/j.endeavour.2023.100902

Ophthalmic Physiol Opt. 2023 Dec 9. doi: 10.1111/opo.13260. Online ahead of print.

ABSTRACT

PURPOSE: There is uncertainty about the effect of increased neonatal protein intake on neurodevelopmental outcomes following preterm birth. The aim of this study was to assess the effect of a change in neonatal nutrition protocol at a major tertiary neonatal intensive care unit intended to increase protein intake on ophthalmic and visual development in school-age children born very preterm.

METHODS: The study cohort comprised children (n = 128) with birthweight <1500 g or gestational age < 30 weeks born at Auckland City Hospital before (OldPro group, n = 55) and after (NewPro group, n = 73) a reformulation of parenteral nutrition that resulted in increased total protein intake during the first postnatal week and decreased carbohydrate, total parenteral fluid and sodium intake. Clinical and psychophysical vision assessments were completed at 7 years’ corrected age, including visual acuity, global motion perception (a measure of dorsal stream function), stereoacuity, ocular motility and ocular health. Composite measures of favourable overall visual, binocular and functional visual outcomes along with individual vision measures were compared between the groups using logistic and linear regression models.

RESULTS: Favourable overall visual outcome did not differ between the two groups. However, global motion perception was better in the NewPro group (p = 0.04), whereas the OldPro group were more likely to have favourable binocular visual outcomes (60% vs. 36%, p = 0.02) and passing stereoacuity (p = 0.02).

CONCLUSIONS: These results indicate subtle but complex associations between early neonatal nutrition after very preterm birth and visual development at school age.

PMID:38069619 | DOI:10.1111/opo.13260

Am J Ind Med. 2023 Dec 9. doi: 10.1002/ajim.23556. Online ahead of print.

ABSTRACT

BACKGROUND: Working from home (WFH) may affect health behaviors and mental health. The coronavirus disease-2019 (COVID-19) pandemic saw many US employees transition to WFH, which has persisted in various job sectors and significantly impacted employees. However, its effects on health outcomes have remained unclear. We aimed to explore the characteristics and health outcomes of, and health-related differences between, WFH and not-WFH groups.

METHODS: Using the 2021 California Health Interview Survey data, we analyzed health behaviors (smoking, alcohol consumption, and fruit-related nutrition) and the mental health status of 12,438 individuals using descriptive statistics, Pearson’s χ² test, and regressions.

RESULTS: A total of 39% were WFH and 61% were not-WFH. Overall, the WFH group had worse health behaviors and mental health than the not-WFH group. Age was associated with smoking in both groups (WFH: b = 0.37; not-WFH: b = 0.35), but with fruit-related nutrition only in the WFH group. Household income and occupation were associated with alcohol consumption in both groups. Age (WFH: b = -1.58; not-WFH: b = -1.39), household income (WFH: b = -0.75; not-WFH: b = -0.34), and job duration (WFH: b = -0.34; not-WFH: b = -0.40) were associated with mental health in both groups; those who were younger and had lower household incomes and job durations had worse mental health.

CONCLUSION: Health management is a clear necessity for the WFH group. Irrespective of WFH status, young workers with shorter than 5 years’ job duration reported mental distress, highlighting a need for distress assessment and management for the young workforce.

PMID:38069590 | DOI:10.1002/ajim.23556

J Sleep Res. 2023 Dec 9:e14118. doi: 10.1111/jsr.14118. Online ahead of print.

ABSTRACT

Diagnostic manuals describe insomnia disorder (ID) characterised by fatigue and sleepiness as diurnal consequences of nocturnal symptoms. However, patients with ID do not frequently report sleepiness in the clinical setting. The present study aimed to investigate subjective sleepiness in ID measured through the Epworth Sleepiness Scale (ESS) and its independence towards daytime functioning and fatigue, and to evaluate cognitive behavioural therapy for insomnia (CBT-I) improvement in daytime consequences and their relationship to sleepiness and fatigue. We retrospectively collected the ESS evaluation in a large sample of 105 healthy controls (HCs), 671 patients with ID, and 602 patients with sleep disorders characterised by excessive daytime sleepiness (EDS). Moreover, we conducted a pre-post evaluation of the ESS in a sub-sample of patients with ID who underwent CBT-I. Component 2 of the Insomnia Severity Index and Profile of Mood States-Fatigue Inertia Scale was used to evaluate daytime functioning and fatigue. Patients with ID reported ESS levels comparable to that observed in HCs and significantly lower than the EDS group. No significant correlation arose between ESS and the diurnal impact of the disorder, suggesting the independence between daytime functioning and sleepiness in ID. Contrarily, insomnia severity and diurnal impact significantly correlated with fatigue. Data showed a statistically significant increase in sleepiness after CBT-I, despite significantly improving daytime consequences and fatigue. Although diagnostic manuals report sleepiness and fatigue as daytime consequences of sleep symptoms in patients with ID, these retrospective data indicate a dissociation between these entities. This evidence aligns with the core feature of ID: the hyperarousal status that pervades patients also during wakefulness.

PMID:38069577 | DOI:10.1111/jsr.14118