Crit Care. 2025 Sep 16;29(1):396. doi: 10.1186/s13054-025-05645-8.
NO ABSTRACT
PMID:40958116 | DOI:10.1186/s13054-025-05645-8
Category: Nevin Manimala
BMC Infect Dis. 2025 Sep 16;25(1):1110. doi: 10.1186/s12879-025-11521-1.
ABSTRACT
BACKGROUND: Acute respiratory infections (ARI) exhibit varying lethality rates, influenced by individual and population factors. This retrospective study aimed to analyse infection frequency, clinical characteristics, and factors associated with lethality in hospitalized patients with seasonal ARI pathogens.
METHODS: Virological and demographic data of hospitalized patients ≥ 18 years who tested positive for at least one ARI viral pathogen (Influenza, Adenovirus, Coronavirus, human Metapneumovirus (hMPV), Parainfluenza, Rhinovirus, Respiratory Syncytial Virus (RSV) and SARS-CoV-2) were collected from 07/2022 to 04/2023 at a German tertiary care hospital. Logistic regression analysis was used to analyse factors influencing lethality. Univariate comparisons examined pathogen-specific differences in length of stay and lethality.
RESULTS: Among 1,657 hospitalized patients with at least one detected ARI pathogen, 89 (5.5%) passed away. Logistic regression analysis indicated a significant association between advanced age and lethality (OR = 1.05 per year, p < 0.0001). Patients infected with ARI pathogens other than SARS-CoV-2 or hMPV exhibited a heightened risk of lethality compared to those with Influenza. While statistical significance was reached only for Adenovirus (OR = 5.99, p = 0.049), elevated risk of lethality was also observed among hospitalized patients infected with Coronavirus (OR = 2.22), RSV (OR = 2.18), and more than one pathogen (OR = 2.07).
CONCLUSIONS: Lethality rates varied among the examined ARI pathogens. Compared to Influenza, Adenovirus, Coronavirus, and RSV showed elevated lethality rates and an increased risk of intrahospital death among ARI-infected patients. RSV emerged as a notable concern for hospitalized adults. Additionally, age also arises as a significant risk factor for lethality associated with ARI during hospitalization.
TRIAL REGISTRATION: This study is a retrospective analysis of fully anonymized routinely collected patient data and does not require registration in a clinical trial registry.
PMID:40958111 | DOI:10.1186/s12879-025-11521-1
BMC Oral Health. 2025 Sep 16;25(1):1408. doi: 10.1186/s12903-025-06782-w.
ABSTRACT
OBJECTIVE: This study aimed to correlate the dimensions of the maxillary sinus in CBCT-reformatted panoramic radiographs to the greater palatine canal geometry and its neighbor structures in CBCT multiplanar images, so considering the limitations of the current study, we could use panoramic radiographs as an alert tool before performing a variety of implant surgical and dental procedures concerning the Greater Palatine Canal (GPC).
METHODS: The GPC pathway and its neighbor structures were assessed in a sample of 48 CBCT Egyptian adult patients’ images (24 females and 24 males) in the three orthogonal planes and correlated to the height, width and hypothetical surface area of the maxillary sinus (MS).
RESULTS: There was a statistically significant difference in sagittal planes among genders regarding GPC pathway, as Type a was the most prominent GPC pathway among females (an antero-inferior direction) in contrast to male cases that shown Type c (posterior-inferior direction, then an anterior-inferior direction) pathway. Male patients had significantly lower GPC angle than female patients (P = 0.022). Males had greater mean values of MS height, width & hypothetical surface area than females. The greater the GPC angle in sagittal plan, the lesser MS height, width & hypothetical surface area. In addition, MS of greater height had more posterior extension (depth).
CONCLUSION: Considering the restrictions of the current retrospective study, the current study illustrated a significant correlation between maxillary sinus (MS) dimensions and greater palatine canal (GPC) anatomy, specifically the GPC pathway and angle. Larger MS (especially height) correlated with GPC with more posterior pathway and lesser angle, which is sex-based association. These findings are with great clinical significance to minimize the risk of GPC neurovascular bundle iatrogenic injury during interventions dealing with posterior maxilla, particularly sinus lifts, implant planning, due to potential impingement from MS expansion.
PMID:40958094 | DOI:10.1186/s12903-025-06782-w
ACS Appl Mater Interfaces. 2025 Sep 16. doi: 10.1021/acsami.4c20938. Online ahead of print.
ABSTRACT
An alternative method for fabricating planar surface-enhanced Raman spectroscopy (SERS) sensors, offering enhanced performance compared to conventional drop-casting techniques, is presented. We synthesized stable gold nanoparticles (AuNPs) with an average diameter of 16 ± 2 nm and developed two types of SERS sensors using pyro-electrohydrodynamic jet printing (p-jet) technology. The first sensor, printed on a glass substrate, featured a corona pattern with sensing areas aligned to the laser spot size, enabling efficient sampling with minimal material waste. The second sensor, fabricated on a dithiol-functionalized gold substrate, demonstrated uniform nanoparticle coverage. SERS activity was evaluated using p-Mercaptoaniline (pMA), yielding intense and reproducible spectra. Raman imaging confirmed consistent SERS activity, uniform nanoparticle distribution, and sensor stability. Statistical analysis indicated high reproducibility in sensor dimensions and shapes, underscoring the potential of p-jet microprinting as a cost-effective, stable, and scalable method for producing high-performance SERS sensors suitable for diverse applications.
PMID:40958078 | DOI:10.1021/acsami.4c20938
Anaesthesiologie. 2025 Sep 16. doi: 10.1007/s00101-025-01592-9. Online ahead of print.
ABSTRACT
BACKGROUND: The response time (“Hilfsfrist”) in Germany is an important planning parameter that determines the arrival times of emergency medical services and is regulated by state legislation. This study analyzes arrival times in the German federal states.
MATERIAL AND METHOD: The German Resuscitation Registry uniformly records arrival times for the first vehicle on the scene and the complete team (team arrival time: ambulance and emergency physician) nationwide. The statistical testing of the null hypothesis, equality between the federal states, was conducted using the Kruskal-Wallis test. Binary logistic regression analyses were used to examine the impact of arrival times on survival rates.
RESULTS: The null hypothesis had to be rejected (p < 0.001), indicating that arrival times differ between the federal states (first vehicle: mean arrival times ranged from 5.7 ± 2.6 min to 7.4 ± 3.5 min; 90th percentile: 9-13 min; team arrival time ranged from 8.6 ± 3.6 min to 11.9 ± 5.9 min; 90th percentile: 13-21 min; 2014-2024: n = 104,657; 201 ambulance services). In 10 out of 16 federal states, fewer than 80% of patients were reached by the first vehicle within 8 min. The regression analyses showed that longer arrival and team arrival times were negatively associated with good neurological recovery at discharge (team arrival time ≥ 12 min: odds ratio, OR =0.54, confidence interval, CI =0.39-0.75, p < 0.001; n = 45,873; 71 reference emergency medical services, EMS, sites).
CONCLUSION: Patients receive qualitatively different levels of care across the federal states due to variations in arrival times. Shorter arrival times are associated with better chances of survival. Equal quality of care is a constitutional requirement by the German constitution but it is not being achieved.
PMID:40958064 | DOI:10.1007/s00101-025-01592-9
J Neurooncol. 2025 Sep 16. doi: 10.1007/s11060-025-05186-8. Online ahead of print.
ABSTRACT
PURPOSE: Predicting future tumor growth from initial imaging of incidentally discovered meningioma (IDM) could inform treatment decisions. However, most factors identified in prior studies on meningioma growth are qualitative. The aim of this study is to identify factors associated with tumor growth using quantitative radiomics features from MRI data.
METHODS: MRI T2 features from initial imaging of 24 tumor growth cases were compared with those of 25 cases without growth. An in-house program was developed to reduce the time required for data analysis. This program is based on the open-source software 3D Slicer 5.6.2 and PyRadiomics 3.1.0. It enables semi-automatic batch t-test analyses for each feature to compare tumor growth and non-growth groups. Regions of interest (ROIs) were placed in the tumor, outer tumor edge, whole brain, and white matter contralateral to the tumor. A total of 107 features were analyzed across seven classifications: First Order, Shape, Gray Level Co-occurrence Matrix, Gray Level Run Length Matrix, Gray Level Size Zone Matrix, Gray Level Dependence Matrix, and Neighboring Gray Tone Difference Matrix. A t-test was used to identify significant predictors.
RESULTS: Ten features across five classifications showed significant differences (p < 0.05): 2 First Order statistics, 2 Shape features, 4 Gy Level Co-occurrence Matrices, 1 Gy Level Size Zone Matrix, and 1 Neighboring Gray Tone Difference Matrix.
CONCLUSIONS: Potential predictors of IDM growth were identified using radiomics features. Future studies with larger cohorts and validation will be essential to confirm the clinical utility and improve the predictive accuracy of these features.
PMID:40958042 | DOI:10.1007/s11060-025-05186-8
Aesthetic Plast Surg. 2025 Sep 16. doi: 10.1007/s00266-025-05244-6. Online ahead of print.
ABSTRACT
INTRODUCTION: In Asia, a square face, which is characterized by prominent mandibular angles or masseter hypertrophy, is considered less aesthetic and masculine by Oriental populations, including Vietnamese. A combination of any two procedures of mandibular ostectomy, outer cortex grinding or ostectomy, and masseter muscle resection was widely presented. In this article, we presented a single-stage procedure combining angle-body-chin curved ostectomy, corticectomy, and/or masseter muscle resection based on four classifications of mandibular angles, which brought satisfactory results in the Vietnamese population.
METHODS: From January 2021 to February 2023, all cases (n = 31) that underwent facial contouring surgery only for aesthetic purposes in our clinic were included in the study. The majority of patients underwent a combination of curved ostectomy, corticectomy, and masseter muscle resection to achieve optimal results. Pre- and postoperative mandibular angles (ArGoMe), the distance between two bilateral angles (G-G), and the distance between soft tissue parts of two bilateral angles (G’-G’) measured by cephalometry were recorded.
RESULTS: The ArGoMe angle significantly increased from 114.3° ± 3.1 to 128.7° ± 5.0 (p < 0.0001). The G-G distance and G’-G’ distance statistically decreased from 97.6 ± 6.6 to 86.2 ± 4.0 mm (p < 0.0001) and from 120.7 ± 7.2 to 111.0 ± 7.2 mm (p < 0.0001). 94% of patients expressed their satisfaction with the results. No severe complications were noted.
CONCLUSIONS: The combination of curved mandibular ostectomy-corticectomy-masseter resection brought satisfactory results to patients with a square face and idiopathic masseter hypertrophy in both frontal and lateral views. This approach was suitable for patients with a prominent mandibular angle and masseter hypertrophy, which might be widely present in the Vietnamese population and other populations with similar anatomic characteristics.
LEVEL OF EVIDENCE III: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
PMID:40958022 | DOI:10.1007/s00266-025-05244-6
Intern Emerg Med. 2025 Sep 16. doi: 10.1007/s11739-025-04110-2. Online ahead of print.
ABSTRACT
The optimal site for needle decompression in tension pneumothorax patients with a body mass index (BMI) over 30 remains debated. This study aimed to identify the most suitable site-second intercostal space at the midclavicular line (2nd ICS in the MCL) or fifth intercostal space at the midaxillary line (5th ICS in the MAL)-by comparing skin-to-pleura distances using point-of-care ultrasound (POCUS). Skin-to-pleura distance measurements at the right 2nd ICS-MCL and the right 5th ICS in the MAL, assessed by three different operators. The primary outcome was to compare the skin-to-pleura distances at the 2nd ICS in the MCL and the 5th ICS in the MAL using POCUS in volunteers with a BMI over 30. The secondary outcome was to evaluate the consistency of different operators in determining the most appropriate site for needle decompression in the management of tension pneumothorax among healthy volunteers with a BMI over 30, using bedside ultrasonography. A total of ninety-one volunteers were enrolled. The skin-to-pleura distance at the 5th ICS in the MAL was found to be statistically significantly greater than that at the 2nd ICS in the MCL in the measurements performed by each operator (Operator 1: p = 0.016; Operator 2: p = 0.002; Operator 3: p = 0.006). The MCL measurements obtained by all three operators demonstrated statistically significant agreement. In obese patients, the 2nd ICS-MCL may be considered the preferred site for needle decompression. Nevertheless, individualized assessment of both sites using bedside ultrasonography is recommended to optimize procedural success and reduce complications.
PMID:40958006 | DOI:10.1007/s11739-025-04110-2
Immunol Res. 2025 Sep 16;73(1):130. doi: 10.1007/s12026-025-09682-x.
ABSTRACT
Efficient utilization of healthcare resources, including laboratory testing, is crucial for environmental sustainability and cost-effectiveness. The diagnosis of APS requires the presence of at least one clinical event (either an objectively confirmed thrombotic event and/or pregnancy complication) and detection of one or more aPL (lupus anticoagulant [LA], IgG/IgM anticardiolipin [aCL], and/or IgG/IgM anti-β2 glycoprotein-1 [aβ2GPI]). However, inappropriate requests for aPL tests contribute to unnecessary healthcare expenses and environmental impact. This study evaluates the appropriateness of aPL testing in a clinical setting. A retrospective analysis was conducted on 642 patients attending the San Giovanni Di Dio Hospital, Florence (11/2023-02/2024). Diagnostic suspicion underlying aPL test requests were classified as appropriate, inappropriate, or unevaluable using a scoring system based on clinical recommendations. Appropriateness assessment was performed independently by two researchers and reconciled with a third expert. Patient demographics, test results, and the specialty of the physicians ordering aPL were recorded and analyzed. Of the 642 queries, 36% were deemed appropriate, 42% inappropriate, and 22% unevaluable. Family physicians accounted for 53% of all test requests but exhibited the highest rate of inappropriate requests (44%). Rheumatologists, internal medicine physicians, and gynecologists demonstrated better adherence to recommendations (with 34%, 30%, and 18% of inappropriate requests, respectively). Only 4.9% of patients underwent comprehensive aPL testing per international standards (Sidney criteria). Among the 115 aPL-positive cases, multiple antibody positivity was more common in appropriate test requests. Inappropriate requests often stemmed from conditions without established links to APS, such as alopecia, hypercholesterolemia, and dysmenorrhea. A considerable proportion of aPL testing in routine practice lacks clinical justification, reflecting variability in guideline adherence across specialties. Inappropriate testing increases healthcare costs, specialist referrals, and environmental burdens. Improved education, adherence to diagnostic recommendations, and sustainable practices are critical to optimizing APS testing and resource utilization.
PMID:40958002 | DOI:10.1007/s12026-025-09682-x
J Math Biol. 2025 Sep 16;91(4):42. doi: 10.1007/s00285-025-02284-z.
ABSTRACT
In this paper, we investigate a two-species Lotka-Volterra competition patch model in a Y-shaped river network, where the two species are assumed to be identical except for their random and directed movements. We show that competitive exclusion can occur under certain conditions, i.e., one of the semi-trivial equilibria is globally asymptotically stable. Specifically, if the random dispersal rates of the two species are equal, the species with a smaller drift rate will drive the other species to extinction, which suggests that smaller drift rates are favored.
PMID:40958001 | DOI:10.1007/s00285-025-02284-z