Zhonghua Yan Ke Za Zhi. 2026 Mar 11;62(3):187-192. doi: 10.3760/cma.j.cn112142-20250619-00279.
ABSTRACT
Objective: To investigate the correlation between macular edema and the anterior chamber angle status in patients with retinal vein occlusion (RVO). Methods: A retrospective case series analysis was adopted. Consecutive RVO patients treated at the Ophthalmology Department of Peking University Third Hospital from October 2011 to May 2013 were included. All patients underwent fluorescein fundus angiography for RVO classification. They were divided into the macular edema and non-macular edema groups based on the angiography results. Static and dynamic gonioscopy were performed to determine the anterior chamber angle status. The statistical analysis was performed using the independent samples t-test, Welch’s t-test, chi-square test, or Fisher’s exact test. The multivariate logistic regression analysis was used to identify factors associated with the occurrence of macular edema by calculating odds ratios and their 95% confidence intervals. Results: A total of 308 RVO patients (308 eyes) who completed all required examinations were included in the study, consisting of 155 males and 153 females, with a mean age of (58.78±14.45) years. Among them, 59 cases (19.16%) had angle closure, while 249 cases (80.84%) had open angles; 221 patients had macular edema (71.75%). The multivariate regression analysis revealed that the main risk factor for the development of macular edema in eyes with RVO was angle closure (odds ratio=2.59, 95% confidence interval: 1.23-6.05, P=0.018), while other factors such as age, gender, eye laterality, intraocular pressure, type of RVO, and cup-to-disc ratio showed no statistically significant association (all P>0.05). Conclusion: The risk of macular edema is significantly higher in RVO patients with angle closure compared to those with open angles.
PMID:41820063 | DOI:10.3760/cma.j.cn112142-20250619-00279