Category: Nevin Manimala

Aust Occup Ther J. 2022 Apr 19. doi: 10.1111/1440-1630.12803. Online ahead of print.

ABSTRACT

INTRODUCTION: Current research evidence suggests that people with schizophrenia have sensory processing difficulties. Sensory modulation has growing evidence for use in this population. This study aimed to evaluate the extent to which health, social, cognitive, and occupational functioning outcomes were impacted by sensory modulation interventions for people with schizophrenia.

METHODS: A prospective observational cohort study using a waitlist control design was used in two large hospital and health services in Queensland, Australia. The study recruited patients who used sensory modulation (n = 30) across the two hospitals and those who did not use sensory modulation interventions as a control (n = 11). Results were analysed using a series of planned comparisons including independent and paired t-tests, and mixed ANOVA was used whenever statistically indicated. The analysed measures were pre- and post-intervention scores.

RESULTS: This study found no statically significant differences between the control and intervention groups at both pre- and post-intervention. However, analysis of results from within the intervention group showed statistically significant improvements between pre- and post-test scores on distress, occupational functioning, and health and social functioning but not on sensory processing and global cognitive processing. Further analysis of results from this study, compared with those from an earlier study on the general population showed significant differences in Low Registration and Sensation Avoiding, as measured by the Adult/Adolescent Sensory Profile, between participants with schizophrenia and those without schizophrenia.

CONCLUSION: This study provides evidence to suggest that sensory modulation interventions can be complementary to standard care when utilised appropriately in clinical settings. Findings also suggest that the sensory profile of people with schizophrenia is different to that of the general population and this may have clinical implications. Further longitudinal research is needed with larger and randomised samples, using more targeted measures to better explore effectiveness of sensory modulation interventions.

PMID:35441391 | DOI:10.1111/1440-1630.12803

Behav Res Methods. 2022 Apr 19. doi: 10.3758/s13428-022-01845-0. Online ahead of print.

ABSTRACT

Research demonstrates that IATs are fakeable. Several indices [either slowing down or speeding up, and increasing errors or reducing errors in congruent and incongruent blocks; Combined Task Slowing (CTS); Ratio 150-10000] have been developed to detect faking. Findings on these are inconclusive, but previous studies have used small samples, suggesting they were statistically underpowered. Further, the stability of the results, the unique predictivity of the indices, the advantage of combining indices, and the dependency on how faking success is computed have yet to be examined. Therefore, we reanalyzed a large data set (N = 750) of fakers and non-fakers who completed an extraversion IAT. Results showed that faking strategies depend on the direction of faking. It was possible to detect faking of low scores due to slowing down on the congruent block, and somewhat less with CTS-both strategies led to faking success. In contrast, the strategy of increasing errors on the congruent block was observed but was not successful in altering the IAT effect in the desired direction. Fakers of high scores could be detected due to slowing down on the incongruent block, increasing errors on the incongruent block, and with CTS-all three strategies led to faking success. The results proved stable in subsamples and generally across different computations of faking success. Using regression analyses and machine learning, increasing errors had the strongest impact on the classification. Apparently, fakers use various goal-dependent strategies and not all are successful. To detect faking, we recommend combining indices depending on the context (and examining convergence).

PMID:35441359 | DOI:10.3758/s13428-022-01845-0

Stat Med. 2022 Apr 19. doi: 10.1002/sim.9369. Online ahead of print.

ABSTRACT

Cluster/group randomized controlled trials (CRTs) have a long history in the study of health sciences. CRT is a special type of intervention trial in which a complete group is randomly assigned to a study condition (or intervention). It is typically performed when individual randomization is difficult/impossible without substantial risk of contamination across study arms or prohibitive from the cost or group dynamics point of view. In this article, the aim is to design and analyze four-level longitudinal cluster randomized trials. The main interest here is to study the difference between treatment groups over time for such a four-level hierarchical data structure. This work is motivated by a real-life study for education based HIV prevention. Such trials are not only popular for administrative convenience, ethical considerations, subject compliance, but also help to reduce contamination bias. A random intercept mixed effects linear regression including a time by intervention interaction is used for modeling. Closed form expression of the power function to detect the interaction effect is determined. Sample size equations depend on correlation among schools but not on correlations among classes or students while, the power function depends on the product of number of units at different levels. Optimal allocation of units under a fixed cost by minimizing the expected standardized variance is also determined and are shown to be independent of correlations among units in any level. Results of detailed simulation studies find the theoretical power estimates based on the derived formulae close to the empirical estimates.

PMID:35441378 | DOI:10.1002/sim.9369

Clin Transl Oncol. 2022 Apr 19. doi: 10.1007/s12094-022-02808-9. Online ahead of print.

ABSTRACT

OBJECTIVE: There is a gap in knowledge regarding the ideal management of patients with early-stage cervical cancer and intermediate-risk features. Here, we present a meta-analysis of the published literature on oncological outcomes in these patients and determine trends in postoperative management.

METHODS: MEDLINE and PubMed were used for literature searches. The inclusion criteria were: English language articles including ≥ 10 patients, patients who underwent radical hysterectomy, nodes negative, studies reporting oncological outcomes and complications treatment-related and compare a surgery-only cohort with a radiotherapy cohort. The PRISMA guidelines were followed. Combined relative risk was calculated using DerSimonian-Laird random-effects model and a forest plot was drawn.

RESULTS: We collected 183 manuscripts on early-stage cervical cancer treated with radical hysterectomy alone or with adjuvant radiotherapy after surgery. A total of eight studies met the inclusion criteria. Regarding oncological outcomes, survival was reported in five studies. The relative risk of recurrence and the relative risk of mortality was similar in both groups independently whether receive or not adjuvant therapy. Most of the studies did not report significant differences regarding morbidity treatment related between the groups, except for a higher rate of lymphedema after radiotherapy.

CONCLUSION: We found that the relative risk of recurrence and mortality was similar in both groups not depending on adjuvant therapy. Therefore, whether radiotherapy adjuvant treatment is indicated remains a topic of debate.

PMID:35441353 | DOI:10.1007/s12094-022-02808-9

AAPS PharmSciTech. 2022 Apr 19;23(5):116. doi: 10.1208/s12249-022-02269-x.

ABSTRACT

Topical drug delivery systems are interesting and popular dosage forms for formulation development. Thai herbs are used in alternative medicine to treat patients suffering from severe illnesses. They have significant economic and cultural value in Thailand. This work prepared Thai herbal topical patches of Lysiphyllum strychnifolium stem extracts using pectin and Eudragit^® NM 30D, and glycerin as a plasticizer. Astilbin was selected as a chemical marker in L. strychnifolium stem extracts. The L. strychnifolium stem extracts showed a statistically significant decrease in nitrate accumulation. The various properties of Thai herbal topical patches were not significantly different from blank patches. However, the trends of the properties depended on the amount of Eudragit^® NM 30D. All ingredients were homogeneously mixed in Thai herbal topical patches and showed a smooth and compact film. The astilbin content was found in a range of 52.72-63.36 μg/cm². The in vitro release of astilbin depended on the amount of Eudragit^® NM 30D. The kinetics of astilbin release were fitted to the Korsmeyer-Peppas model. The astilbin showed low permeation; thus, polyethylene glycol 400 was used as a permeation enhancer. Polyethylene glycol 400 could increase the permeation rates of astilbin and the cumulative amount of astilbin in pig skin. This would be suitable for preparing the Thai herbal topical patches and could be developed for pharmaceutical and herbal products.

PMID:35441285 | DOI:10.1208/s12249-022-02269-x

Res Synth Methods. 2022 Apr 19. doi: 10.1002/jrsm.1561. Online ahead of print.

ABSTRACT

The meta-analytic-predictive (MAP) approach is a Bayesian meta-analytic method to synthesize and incorporate information from historical controls in the analysis of a new trial. Classically, only a single parameter, typically the intercept or rate, is assumed to vary across studies, which may not be realistic in more complex models. Analysis of covariance (ANCOVA) is often used to analyze trials with a pretest-posttest design, where both the intercept and the baseline effect (coefficient of the outcome at baseline) affect the estimated treatment effect. We extended the MAP approach to ANCOVA, to allow for variation in the intercept and the baseline effect across studies, and possibly also correlation between these parameters. The method was illustrated using data from the Alzheimer’s Disease Cooperative Study (ADCS) and assessed with a simulation study. In the ADCS data, the proposed multivariate MAP approach yielded a prior effective sample size of 79 and 58 for the intercept and the baseline effect respectively and reduced the posterior standard deviation of the treatment effect by 12.6%. The result was robust to the choice of prior for the between-study variation. In the simulations, the proposed approach yielded power gains with a good control of the type I error rate. Ignoring the between-study correlation of the parameters or assuming no variation in the baseline effect generally led to less power gain. In conclusion, the MAP approach can be extended to a multivariate version for ANCOVA, which may improve the estimation of the treatment effect. This article is protected by copyright. All rights reserved.

PMID:35439840 | DOI:10.1002/jrsm.1561

J Neurol Surg A Cent Eur Neurosurg. 2022 Apr 19. doi: 10.1055/s-0042-1743531. Online ahead of print.

ABSTRACT

BACKGROUND: In this study, we analyze our institutional experience and personal impressions using minimally invasive spine surgery (MISS) to describe our learning curve and how experience influenced different parameters of the surgical procedure.

METHODS: The study was conducted prospectively and included the first consecutive 152 patients treated with MISS techniques. Patient demographics, surgical data, length of hospital stay, and clinical outcome were reviewed. The cohort was divided into consecutive quarters. Comparison between the quarters and timeline analysis were made to assess the learning curve.

RESULTS: Only percutaneous transpedicular screw fixation was performed in 65 cases, minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) in 70 cases, and vertebral body replacement in 4 cases. The average blood loss was 113.3, 115, 106.6, and 107.1 mL for each quarter. The average operative time was 155.0, 143.2, 134.5, and 133.8 minutes for the four quarters, whereas the average radiation exposure time was 105.4, 85.3, 46.2, and 45.2 seconds. Differences in the operative time and radiation exposure time between the first to third and the first to fourth quarters were statistically significant.

CONCLUSIONS: Some advantages of MISS techniques could be observed with the very first cases and were not related significantly with the surgeon’s experience with MISS. With the acquisition of more experience, some disadvantages of MISS techniques such as longer operative time and longer X-ray exposure can be substantially reduced. Surgical experience, familiarity of the team with the MISS instrumentation, and good patient selection are crucial for achieving all the benefits of MISS.

PMID:35439828 | DOI:10.1055/s-0042-1743531

Pain. 2022 Mar 7. doi: 10.1097/j.pain.0000000000002623. Online ahead of print.

ABSTRACT

showed that ACPs were not less popular than adolescents without chronic pain. Second, ACPs nominated each other more often as being part of the same peer group. Third, results regarding friendship quality showed that adolescents with more pain problems perceived the relationship with their friends as less positive (e.g., support) and more negative (e.g., conflict) than adolescents with less pain problems. Finally, positive and negative friendship quality moderated the relationship between pain and emotional distress.The current study contributes to the literature on the importance of ACPs’ peer relationships. Clinical implications and directions for future research are discussed.

PMID:35439797 | DOI:10.1097/j.pain.0000000000002623

Nicotine Tob Res. 2022 Apr 19:ntac108. doi: 10.1093/ntr/ntac108. Online ahead of print.

ABSTRACT

INTRODUCTION: Differential reasons for e-cigarette use for men and women have seldom been examined, and there is no systematic overview of this research literature. The aim for this review is to conduct a systematic review of the literature to identify gender differences in the reasons for e-cigarette use.

METHODS: Systematic searches covered in three databases found 866 unique articles: Web of Science, Pubmed and PsycInfo. Twenty six studies met the inclusion criteria and were reviewed. Reasons for e-cigarette use were sorted into 17 distinct categories.

RESULTS AND CONCLUSIONS: Fifteen studies identified statistically significant differences in reasons between men and women. Frequently assessed reasons for e-cigarette use across studies included Health/Smoking Cessation, Experimentation/Curiosity, Enjoyment/Pleasure, Use in Specific Locations, Acceptable to Others, and Cost. Of those that identified statistically significant differences in reasons between men and women, the findings varied considerably, and some reasons for e-cigarette use were found to be significant in only one or two studies. Most of the reasons identified were only measured in a small number of studies, complicating our ability to make intervention recommendations based on gender. Additionally, we limited our literature search to peer-reviewed studies. Of the reason categories that did find significant differences between gender, such as reasons related to Health/Smoking Cessation, the outcomes were not consistent across studies. Future studies are needed to identify potentially important differences in the reasons for e-cigarette use among men and women.

IMPLICATION: This systematic review aims to uncover gender differences in e-cigarette use to understand important differences in motivation for use that may help us better understand strategies for prevention and treatment of tobacco use disorder. This review is the first on this topic and could provide further insight on patterns of e-cigarette use across gender.

PMID:35439816 | DOI:10.1093/ntr/ntac108

J Glaucoma. 2022 Apr 14. doi: 10.1097/IJG.0000000000002037. Online ahead of print.

ABSTRACT

PRCIS: Using an intracanalicular dexamethasone insert or topical prednisolone following iStent and Hydrus surgery provided similar short-term control of post-operative inflammation.

PURPOSE: To compare post-operative inflammation in patients who received an intracanalicular dexamethasone insert or topical prednisolone after iStent or Hydrus surgery.

PATIENTS AND METHODS: Patients receiving a dexamethasone insert after iStent or Hydrus insertion were included and compared to age-matched controls who received topical prednisolone. Pre-operative data were recorded. Post-operative inflammatory cell and the proportion of patients with zero anterior chamber cells was recorded at month 1. Post-operative IOP and rate of cystoid macular edema (CME) were recorded at months 1 and 3.

RESULTS: 40 eyes receiving topical prednisolone were compared to 35 eyes receiving a dexamethasone insert after iStent or Hydrus insertion. Mean post-operative inflammatory cell for the topical group at month 1 was 0.2±0.3, and the dexamethasone group, 0.3±0.5;P=0.816. 70% of patients in the topical group had zero anterior chamber cell at post-operative month 1 compared to 75.8% in the dexamethasone group,P=0.583. Mean pre-operative IOP for the topical group was 18.8±5.5 and the dexamethasone group was 17.1±4.1,P=0.064. Mean post-operative IOP for the topical group at months 1 and 3 was 17.6±6.4 and 15.1±3.1, respectively and the dexamethasone group, 17.5±4.8 and 15.0±3.4, respectively;P=0.772 and 0.884. One patient developed CME in each group.

CONCLUSIONS: There was no statistically significant difference in the proportion of patients who had zero anterior chamber cell at post-operative month 1 between groups.

PMID:35439795 | DOI:10.1097/IJG.0000000000002037