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Nevin Manimala Statistics

Intersectionality and depression symptoms in Mexican adults aged ≥50, MHAS 2001 and 2012

Salud Publica Mex. 2023 Sep 15;65(5, sept-oct):475-484. doi: 10.21149/14733.

ABSTRACT

OBJECTIVE: To analyze, from the perspective of intersectionality, the association of social inequality dimensions (occupation, poverty, and educational level) and socio-demographic and health characteristics with the proportion of depressive symptoms among males and females aged 50 years and older who participated in the 2001 and 2012 waves of the Mexican Health and Aging Study (MHAS).

MATERIALS AND METHODS: Descriptive analysis and logistic regression models stratified by sex were performed, including interaction terms between poverty, educational level, and employment conditions on the presence of depressive symptoms.

RESULTS: The proportion of females with depressive symptoms was significantly higher than that of males in both waves. A high proportion of older females in poverty, with five years or less of education and manual occupational activities, reported depressive symptoms in the MHAS-2001. The interactions evaluated between occupation, poverty, and educational level were not statistically significant under adjusted models; however, disability and comorbidities were associated with depressive symptoms in both sexes.

CONCLUSION: A higher proportion of females have depressive symptoms under conditions of inequality; however, the effect of the intersection between employment and socio-demographic characteristics on depressive symptoms was not observed under adjusted models.

PMID:38060918 | DOI:10.21149/14733

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Nevin Manimala Statistics

Evaluation of commercial aerosol insecticides for control of Aedes aegypti susceptible or resistant to pyrethroids

Salud Publica Mex. 2023 Mar 10;65(2 mar-abr):151-159. doi: 10.21149/14232.

ABSTRACT

OBJECTIVE: To evaluate indoor use of commercial aerosols for dengue vector mosquito control, and estimate the number of treatable houses per can.

MATERIALS AND METHODS: Four aerosol products containing combinations of pyrethroids (two containing propoxur and one containing synergists too), were evaluated with mosquitoes in a room of a Tapachulastyle house. Eight cages containing 20 insecticide susceptible or resistant females were hung from tripods, another set was placed in sheltered areas of the room. From the entrance of the room, one of 4-9 concentrations was sprayed for each aerosol, leaving the mosquitoes for 30 min after sprayed. Mortality was recorded after 24 h and lethal concentrations were calculated.

RESULTS: Aerosol A had the highest LC50, with 0.308 g for mosquitoes hanging from tripods and 0.453 g for sheltered mosquitoes; followed by aerosols C, D and B, with statistical differences between types of exposure.

CONCLUSIONS: Aerosols B-D could spray 20-25 3-room houses (56 m3-room), killing all resistant mosquitoes. Aerosols may become a good tool for indoor mosquito control, if the optimal concentration and correct spray method are used.

PMID:38060852 | DOI:10.21149/14232

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Nevin Manimala Statistics

Value evaluation of serum (sdLDLc*HCYc)/HDLc ratio in the stability of intracranial arterial plaques in patients with acute cerebral infarction

Acta Biochim Pol. 2023 Dec 7. doi: 10.18388/abp.2020_6817. Online ahead of print.

ABSTRACT

BACKGROUND: We aimed to analyze the value of serum (sdLDLc*HCYc)/HDLc ratio in the stability of intracranial arterial plaques among patients with acute cerebral infarction.

METHODS: A retrospective analysis was conducted on 140 patients with acute cerebral infarction admitted to the neurology department and 101 healthy individuals for regular examinations in our hospital from 2013 to 2019, who were respectively allocated into the study group and the control group. Participants in both groups were measured for serum sdLDLc, HDLc, and HCYc using peroxidase method, enzyme-linked immunosorbent assay, and enzyme method, respectively. The laboratory indexes of the two groups were compared. The multivariate logistic regression analysis was done to analyze the influencing factors of the stability of intracranial artery plaque in patients with acute cerebral infarction. The value of high-density lipoprotein cholesterol (HDL-C), homocysteine, sdLDLc, (sdLDLc*HCYc)/HDLc in diagnosing the stability of intracranial artery plaque was also evaluated in patients with acute cerebral infarction.

RESULTS: There was no distinct difference in height, hypertension, diabetes, coronary heart disease, smoking history and drinking history between the two groups (P>0.05). The study group showed statistically significant differences in age, gender, weight, and BMI (P<0.05). The current study demonstrated no statistical difference in the levels of TG, low-density lipoprotein cholesterol (LDL-C), α-lipoprotein, and HCYc between the two groups (P>0.05). However, the levels of TC, HDL-C, sdLDLc, (sdLDLc*HCYc)/HDLc in the study group were significantly different when comparing with the control group (P<0.05). No statistically significant difference was found in the levels of TG, triglycerides, LDL-C, α-lipoprotein, and HCYc among patients with different degrees of stenosis in the study group (P>0.05). The level of HDL-C was significantly lower in cases of severe stenosis compared to no stenosis, mild stenosis and moderate stenosis, with severe stenosis showing the lowest levels; mild stenosis had lower levels than no stenosis, while moderate stenosis had lower levels than both no stenosis and mild stenosis (P<0.05). The levels of sdLDLc, (sdLDLc*HCYc)/HDLc exhibited a significant increase in cases of severe stenosis as compared tono stenosis, mild stenosis, and moderate stenosis. Furthermore, the levels of sdLDLc, (sdLDLc*HCYc)/HDLc were found to be higher in moderate stenosis as compared to no stenosis and mild stenosis. Similarly, the levels of sdLDLc, (sdLDLc*HCYc)/HDLc were observed to be higher in mild stenosis than no stenosis (P<0.05).The independent variables were set as the indicators with difference in single factor comparison, including age, gender, BMI, TC, LDL-C, HDL-C, HCYc, sdLDLc, (sdLDLc*HCYc)/HDLc. The dependent variable was the stability of intracranial artery plaque in patients with acute cerebral infarction. After variable selection, the results showed that the factors influencing the stability of intracranial artery plaque in patients with acute cerebral infarction were age, BMI, (sdLDLc*HCYc)/HDLc. The degree of plaque enhancement was used as a criterion to reflect the stability of plaque. ROC curve analysis showed that (sdLDLc*HCYc)/HDLc had a higher evaluation value for the stability of intracranial artery plaque than HDL-C, homocysteine, and sdLDLc in patients with acute cerebral infarction.

CONCLUSION: The serum (sdLDLc*HCYc)/HDLc ratio was found to have potential in evaluating the stability of intracranial arterial plaques in patients with acute cerebral infarction.

PMID:38060820 | DOI:10.18388/abp.2020_6817

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Nevin Manimala Statistics

Critical behaviors of nonlinear contagion models with recurrent mobility patterns

Chaos. 2023 Aug 1;33(8):083145. doi: 10.1063/5.0155257.

ABSTRACT

Recently, there has been a lot of discussion about the nonlinearity property of contagion processes in epidemic spreading on social networks with various structures. In this paper, we propose a nonlinear contagion model in networked metapopulations to investigate the critical behavior of epidemics with recurrent mobility patterns. First, we build up a discrete-time Markovian chain model to formulate the spreading of susceptible-infected-susceptible-like diseases. Additionally, we develop a practicable framework to analyze the impact of mobility on the epidemic threshold and derive the theoretical condition for the transition of an epidemic from a local to a global scale. This transition is associated with multiple discontinuous phase changes. We validate our analytical results through extensive numerical simulations on both regular and heterogeneous networks. Our findings offer a useful tool to discuss the implementation of prevention strategies such as quarantine and lockdown.

PMID:38060780 | DOI:10.1063/5.0155257

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Nevin Manimala Statistics

Sign patterns symbolization and its use in improved dependence test for complex network inference

Chaos. 2023 Aug 1;33(8):083131. doi: 10.1063/5.0160868.

ABSTRACT

Inferring the dependence structure of complex networks from the observation of the non-linear dynamics of its components is among the common, yet far from resolved challenges faced when studying real-world complex systems. While a range of methods using the ordinal patterns framework has been proposed to particularly tackle the problem of dependence inference in the presence of non-linearity, they come with important restrictions in the scope of their application. Hereby, we introduce the sign patterns as an extension of the ordinal patterns, arising from a more flexible symbolization which is able to encode longer sequences with lower number of symbols. After transforming time series into sequences of sign patterns, we derive improved estimates for statistical quantities by considering necessary constraints on the probabilities of occurrence of combinations of symbols in a symbolic process with prohibited transitions. We utilize these to design an asymptotic chi-squared test to evaluate dependence between two time series and then apply it to the construction of climate networks, illustrating that the developed method can capture both linear and non-linear dependences, while avoiding bias present in the naive application of the often used Pearson correlation coefficient or mutual information.

PMID:38060778 | DOI:10.1063/5.0160868

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Nevin Manimala Statistics

Machine learning enhanced Hankel dynamic-mode decomposition

Chaos. 2023 Aug 1;33(8):083133. doi: 10.1063/5.0150689.

ABSTRACT

While the acquisition of time series has become more straightforward, developing dynamical models from time series is still a challenging and evolving problem domain. Within the last several years, to address this problem, there has been a merging of machine learning tools with what is called the dynamic-mode decomposition (DMD). This general approach has been shown to be an especially promising avenue for accurate model development. Building on this prior body of work, we develop a deep learning DMD based method, which makes use of the fundamental insight of Takens’ embedding theorem to build an adaptive learning scheme that better approximates higher dimensional and chaotic dynamics. We call this method the Deep Learning Hankel DMD. We likewise explore how our method learns mappings, which tend, after successful training, to significantly change the mutual information between dimensions in the dynamics. This appears to be a key feature in enhancing DMD overall, and it should help provide further insight into developing other deep learning methods for time series analysis and model generation.

PMID:38060776 | DOI:10.1063/5.0150689

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Nevin Manimala Statistics

Cardiovascular Disorder Risk Assessment Among Police Personnel in Bengaluru City, India, Using World Health Organization/International Society of Hypertension Risk Prediction Chart

Cureus. 2023 Nov 6;15(11):e48378. doi: 10.7759/cureus.48378. eCollection 2023 Nov.

ABSTRACT

Context Cardiovascular diseases (CVDs) are important causes of premature death and disability and elevated healthcare costs. A significant percentage of this morbidity and mortality could be prevented by population-based strategies and cost-effective interventions for those at risk and with established diseases. Aim This study aims to estimate the 10-year risk of cardiovascular events (fatal or non-fatal) among police personnel in Bengaluru City, India. Materials and methods Police personnel above 40 years of age in Bengaluru City, India, were screened for CVD risk using the WHO/International Society of Hypertension (ISH) chart from November 2019 to June 2021. Data was collected by the multistage random sampling method by direct interview at the police station using a semi-structured questionnaire. CVD risk and associated factors were assessed using the WHO/ISH risk prediction chart. Data was entered into Microsoft Office Excel (Microsoft Corporation, Washington, United States) and analyzed using SPSS Statistics version 20.0 (IBM Corp. Released 2011. IBM SPSS Statistics for Windows, Version 20.0. Armonk, NY: IBM Corp.). Results Among 400 study participants, 9.3% (n=37) had a high risk, 2.3% (n=9) had a moderate risk, and 88.5% (n=354) had a low risk of developing fatal or non-fatal cardiovascular events in the next 10 years. Cardiovascular risk was found to be associated with certain socio-demographic and behavioral risk factors. Furthermore, a significant association (p<0.05) was found between CVD risk and the presence of comorbidities such as diabetes and hypertension. Conclusion The study indicates that there is a high burden of predicted cardiovascular risks among the study participants. The WHO/ISH chart can be used as a simple tool for cardiovascular risk stratification.

PMID:38060764 | PMC:PMC10699544 | DOI:10.7759/cureus.48378

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Nevin Manimala Statistics

Comparison of Risk Factors Between Syndesmotic Screws With and Without Breakage

Cureus. 2023 Nov 5;15(11):e48320. doi: 10.7759/cureus.48320. eCollection 2023 Nov.

ABSTRACT

Background Screw fixation continues to be a commonly used treatment for syndesmotic disruption; however, screw breakage remains a complication post-fixation. Despite this complication, investigation on the variability of surgical placement in conjunction with syndesmotic screw characteristics affecting breakage has not been fully elucidated. The purpose of this study is to compare patients with syndesmotic screw breakage versus those with intact screws based on surgically controlled variables. Methods A total of 176 patients and 260 syndesmotic screws were included in the study, 88 patients each with and without broken syndesmotic screws. A retrospective analysis of patients who underwent syndesmotic screw fixation was performed. Patients with syndesmotic screw breakage were compared to those with intact screws. Screw width and length, the number of screws used, fracture type, and the number of cortices for fixation were all collected. Further analysis included radiographic measurement of syndesmotic screw angle and height of placement above the tibial plafond. Results Decreased screw width, increased number of screws used, and younger age were all associated with increased rates of screw breakage (p < .001, p = .019, p = 0.020). No statistical difference was appreciated between groups based on screw length, number of cortices used, or angle relative to the tibial plafond (p = .2432, p = .4699, p = .9233). Conclusion Higher placement of syndesmotic screws above the tibiotalar joint, specifically greater than 20 mm above the tibial plafond, increases the screw breakage rate. Decreased screw width, increasing numbers of screws used, and younger age were all also associated with increased rates of screw breakage. No difference was appreciated based on the screw angle relative to the tibial plafond.

PMID:38060758 | PMC:PMC10697833 | DOI:10.7759/cureus.48320

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Nevin Manimala Statistics

Relationship Between Overnight Dexamethasone Suppression Test and Aging

Cureus. 2023 Nov 6;15(11):e48383. doi: 10.7759/cureus.48383. eCollection 2023 Nov.

ABSTRACT

Background This study aims to investigate the relationship between suppressed cortisol levels measured after the 1-mg dexamethasone suppression test (DST) and age based on the hypothesis that aging can alter the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Methodology Data obtained by the retrospective evaluation of suppressed 1-mg overnight DST results of adults aged ≥18 years with adrenal incidentaloma or suspected endogenous hypercortisolemia between December 2021 and March 2023 were subjected to age-dependent correlation analysis. Individuals aged between 18 and 90 years (n = 1111) were classified into the following four groups: <30 years, 30-49 years, 50-69 years, and >70 years. DST results were compared according to age groups. Results Median post-DST cortisol was 18.49 nmol/L, with a level of 17.9 nmol/L in females and 20.7 nmol/L in males. The overall rate of DST suppression was 62.7%, with a rate of 63.8% in females and 59.7% in males. On pairwise comparisons of all age groups, there was a difference in post-DST cortisol levels (p = 0.000). Our statistical analysis revealed a strong positive correlation between age and cortisol levels after DST. Conclusions The negative feedback mechanism for cortisol may be altered in older patients. Therefore, the 1-mg DST may yield a higher rate of false positives in the elderly.

PMID:38060754 | PMC:PMC10699728 | DOI:10.7759/cureus.48383

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Nevin Manimala Statistics

Assessing the Predictive Efficacy of Lok Score in Identifying Esophageal Varices in Liver Cirrhosis Patients: A Cross-Sectional Study

Cureus. 2023 Nov 6;15(11):e48360. doi: 10.7759/cureus.48360. eCollection 2023 Nov.

ABSTRACT

Introduction Liver cirrhosis is a global health concern with various etiologies, leading to portal hypertension and gastroesophageal varices. Variceal bleeding, a severe complication of cirrhosis, necessitates early detection and intervention to reduce mortality. Endoscopic screening is the gold standard for varices detection but is invasive and expensive. This study evaluates the Lok Score, a non-invasive predictive tool, for identifying esophageal varices in patients with liver cirrhosis. Materials and methods A cross-sectional study involving 150 liver cirrhosis patients was conducted. The Lok score was calculated using specific parameters. Patient data, including age, gender, etiology of liver cirrhosis, Child-Pugh class, varices presence, and grades, were recorded. Statistical analysis was performed using IBM Corp. Released 2013. IBM SPSS Statistics for Windows, Version 22.0. Armonk, NY: IBM Corp., and diagnostic parameters for Lok Score were computed. Results The study demonstrates that the Lok score exhibits significant potential as a predictive tool for esophageal varices. The mean Lok score significantly differed between individuals with and without varices, suggesting a correlation between Lok score and varices presence. Higher Lok scores may indicate more advanced varices. Utilizing the Lok score in clinical practice could lead to timely interventions, improving patient outcomes. Conclusion The Lok score shows promise as a valuable predictive tool for esophageal varices in liver cirrhosis patients. Early identification using this non-invasive parameter can aid in risk stratification and guide appropriate management strategies. However, further validation and larger studies are needed to fully integrate the Lok score into clinical practice for the benefit of cirrhosis patients.

PMID:38060753 | PMC:PMC10699156 | DOI:10.7759/cureus.48360