Category: Nevin Manimala

BMC Nurs. 2025 Jun 24;24(1):668. doi: 10.1186/s12912-025-03241-3.

ABSTRACT

BACKGROUND: A professional practice environment enhances health worker recruitment and retention and contributes to quality patient care and health system strengthening. Hence, improving the professional practice environments of nurses at hospitals could improve the performance of the health system, increase work passion, and decrease organizational dehumanization.

AIM: To assess nurses’ perceptions of the professional practice environment and its relation to organizational dehumanization and work passion.

METHOD: A descriptive correlational research design was used. A convenience sample of staff nurses (n = 274) was recruited who worked in critical care units and inpatient departments at the National Liver Institute (NLI) in Shebin Elkom city/Menoufia Governorate, Egypt. Three instruments were used: the nursing professional practice environment questionnaire, the organization dehumanization scale, and the work passion scale.

RESULTS: More than two-thirds of the study subjects (72.3%) reported a favorable professional practice environment. The highest mean score and first ranking was related to the dimension of teamwork. The lowest mean score and lowest rank was associated with communication about patients. Additionally, more than two-thirds of the nurses studied perceived a feeling of not being dehumanized by their organization and a high level of passion toward their work (63% and 71.6%, respectively).

CONCLUSION: There was a statistically significant negative correlation between the professional practice environment and organizational dehumanization. Moreover, there was a statistically significant positive correlation between the professional practice environment and work passion.

IMPLICATION FOR NURSING PRACTICE: Managers must design interventions to teach staff members that they are valued as individuals rather than expendable goods. To make staff members feel less dehumanized and more supported, hospitals and their managers may apply particular human resources practices, such as lowering workload, enhancing job stability, and providing training and development opportunities for their growth and grooming.

PMID:40555989 | DOI:10.1186/s12912-025-03241-3

Int J Behav Med. 2025 Jun 24. doi: 10.1007/s12529-025-10375-w. Online ahead of print.

ABSTRACT

BACKGROUND: China is facing a blood shortage crisis and needs to increase its voluntary blood donation rates. Since current programs to promote blood donation may not be sufficient to meet the rising demand, innovative approaches are needed. Behavioral sciences can provide useful insights for developing behavioral interventions to enhance blood donation. However, there have been few empirical studies to evaluate the efficacy of such interventions across different potential and existing donor subgroups.

METHOD: This randomized controlled trial and latent class analysis (LCA) empirically evaluated the effect of online behavioral interventions on blood donation willingness, intention, and behavior on different donor subgroups in China. In 2022, 3280 participants of diverse sociodemographic characteristics in mainland China were recruited through an online survey platform and completed a baseline survey. Participants were randomized to one of five online interventions (stimulating individual standards of fairness, using eye cues to prime individuals, self-imposed penalties for goal failure, presenting blood shortage statistics in China, and a World Health Organization blood donation poster) in the middle of the survey and were provided information on where to donate blood at the end of the survey. To measure post-intervention blood donation, participants were invited to complete a follow-up survey 3 to 4 weeks after the baseline survey. Six donor subgroups were identified using LCA, and differential treatment effects on actual blood donation were assessed using regression analysis based on a classify-analyze approach.

RESULTS: Our results showed that presenting blood shortage statistics was the most effective intervention for increasing blood donation among a subgroup of respondents characterized by high educational attainment, while three out of six classes had low donation rates regardless of the intervention.

CONCLUSION: Targeted, online intervention campaigns show promise in efficiently augmenting voluntary blood donation rates in China.

TRIAL REGISTRATION: ChiCTR2200060481 (Chinese Clinical Trials Registry).

PMID:40555968 | DOI:10.1007/s12529-025-10375-w

Environ Sci Pollut Res Int. 2025 Jun 24. doi: 10.1007/s11356-025-36648-1. Online ahead of print.

ABSTRACT

Recently, the volume and growth of industrial as well as agricultural waste have caused environmental pollution. However, this issue can be mitigated through recycling and reutilization of such waste products. Therefore, this paper evaluated the potential of palm oil fuel ash (POFA), garnet waste, and sawdust as sustainable modified asphalt binders and mixtures as a substitute strategy to encourage waste recycling in road pavement construction. POFA, garnet waste, and sawdust were blended individually with asphalt grade 60/70 with varied amounts of 0% (control), 3%, 6%, and 9%. Moreover, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray fluorescence (XRF), as well as X-ray diffraction (XRD) were utilized to analyze the microstructures of raw waste materials. The physical characteristics with regard to the modified asphalt binder were determined by employing softening point, penetration, and viscosity tests. Consequently, the modified asphalt mixture was assessed using the Marshall stability test. Specifically, adding 6% POFA, 3% garnet waste, and 3% sawdust performs best in stability as a modified asphalt mixture. The correlation of stability, flow, bulk density, and stiffness for POFA-, garnet waste-, and sawdust-modified asphalt mixture was significant, with a strong coefficient of determination (R²) for all Marshall stability parameters. The statistical analysis, including one-way ANOVA and Tukey’s HSD test, revealed that the percentage levels of 0%, 3%, and 6% exhibited significant differences in stability and stiffness, highlighting the optimal modification levels for enhanced mechanical performance. These findings highlight the potential of POFA, garnet, and sawdust as effective alternative additives as asphalt modifiers, contributing to sustainable road construction by promoting the use of industrial and agricultural waste materials, reducing environmental impact, and enhancing pavement performance.

PMID:40555958 | DOI:10.1007/s11356-025-36648-1

Biol Trace Elem Res. 2025 Jun 25. doi: 10.1007/s12011-025-04710-1. Online ahead of print.

ABSTRACT

Using nanotechnology in zinc supplementation may increase efficiency, reducing offered amounts and, therefore, allowing for lower cost and minimized environmental damage due to Zn contamination. This study aims to evaluate the kinetics of zinc, derived from micro- and nanometric zinc oxide, by radiolabeling this mineral through neutron activation. Eight Santa Ines ewes, around 10 months old and 23.6 ± 2.0 kg of body weight, were split into two treatments. After adaptation, they were transferred to metabolism evaluation cages, receiving capsules containing 50 mg of ⁶⁵ZnO (with average 54.85 kBq of ⁶⁵Zn), micro- or nanometric, on a single oral dose. After the capsules’ ingestion, collections of blood samples were made (0.25h, 0.5h, 1h, 2h, 6h, 14h, 24h, and every 24h thereafter), whereas feces and urine collections were made daily through the tenth day, when the animals were euthanized, and their tissues and gastrointestinal contents collected for ⁶⁵Zn counts and Zn measurement. The nanometric ⁶⁵ZnO treatment presented a biological half-life 12h longer than the micrometric ⁶⁵ZnO, although without statistical difference. The nanometric ⁶⁵ZnO also had higher recovery rates in feces throughout the experiment (p < 0.0001). Generally, the ⁶⁵Zn distribution in the tissues was similar, with the spleen being the only exception, showing higher counts in the micrometric ⁶⁵ZnO group (p < 0.05). In conclusion, our results suggest that ZnO nanoparticles may be as efficient as its micrometric counterpart, although further studies are needed to evaluate the differences found in the spleen, large intestine counts, and biological half-life.

PMID:40555953 | DOI:10.1007/s12011-025-04710-1

J Robot Surg. 2025 Jun 24;19(1):323. doi: 10.1007/s11701-025-02499-8.

ABSTRACT

BACKGROUND: There is limited published data evaluating the safety of the da-Vinci-SP1098 platform and only a few utilize the Clavien-Dindo Classification (CDC). Comprehensive complication index (CCI) is developed to overcome the restrictions of the CDC. We aimed to compare the perioperative outcomes of hysterectomy for benign disease with the da-Vinci-SP1098 platform (SPORT-SP-H) with the multiport-XI-hysterectomy (MP-Xi-H).

METHODS: We conducted a retrospective cohort study incorporating a total of 96 patients at a tertiary academic center. Parameters included demographic features, Charlson comorbidity index, Surgical APGAR, indications, and concurrent procedures. Perioperative outcomes included CCI score, CDC grade, length of operation, estimated blood loss, intraoperative complications, length of stay, and conversion rate, sequelae, failure to cure, reoperation and emergency department visit within 1 month. Univariate and multivariate analysis for CCI, CDC and operation duration was undertaken.

RESULTS: Demographic factors were similar. Charlson’s comorbidity index (B = 1.43, 95% CI 0.17-2.6, p = 0.02) was found to be the only independent predictor of CCI in the multivariate analysis. There were no grade IV or higher CDC postoperative complications. Except CDC grade I, all were similar between the cohorts. Operation time was significantly longer in SPORT-SP-H (178, r 85-258) compared to MP-Xi-H (123.5, r 74-218, p < 0.0001). Length of hospital stay and other parameters were comparable between the groups (p > 0.05). Independent predictors of longer operation time were SPORT-SP-H, uterine weight and concurrent procedures.

CONCLUSIONS: SPORT-SP-Hysterectomy (SP1098) appears to be an alternative to multiport robotic hysterectomy but with a longer operating time. Morbidity is related to surgical complexity and patient comorbidities rather than the robotic platform.

PMID:40555946 | DOI:10.1007/s11701-025-02499-8

J Imaging Inform Med. 2025 Jun 24. doi: 10.1007/s10278-025-01572-w. Online ahead of print.

ABSTRACT

Second opinions in radiology are crucial for accurate diagnosis and patient management but often lack standardization, leading to inefficiencies and suboptimal reimbursement. We redesigned the second opinion workflow leveraging existing tools in the EMR. Summary statistics as well as post-implementation surveys were conducted among ordering providers and radiologists to gauge the process. Reimbursement data from August 2021 to October 2022 was also analyzed. The Abdomen division accounted for 47% of second opinion exams, followed by Neuroradiology at 26%, Chest at 17%, Nuclear Medicine at 9%, and MSK at 1%. CT scans comprised 64%, MR 26%, NM 9%, and US 1%. Survey participants reported an improvement in user-friendliness ratings for the second opinion process from 2 to 4.4 (p < 0.07), with substantial positive trends among ordering providers (Cohen’s d = 2.00). Satisfaction with perceived timeliness of report availability was high across both groups, and radiologists perceived workflow efficiency improved from 2.7 to 4 (p = 0.036). The new workflow achieved a 91.9% collection success rate. Standardizing the second opinion workflow enhances operational efficiency, user satisfaction and reimbursement, thereby improving patient care.

PMID:40555944 | DOI:10.1007/s10278-025-01572-w

Obes Surg. 2025 Jun 25. doi: 10.1007/s11695-025-08008-y. Online ahead of print.

ABSTRACT

BACKGROUND: Opioids are commonly used in general anesthesia for pain management. However, they are related to obvious side effects. Patients with obesity undergoing laparoscopic sleeve gastrectomy are at higher risk of experiencing adverse effects associated with opioids. However, there is great heterogeneity in how to select and combine antinociceptive drugs to replace opioids. This randomized controlled double-blind study was conducted to evaluate the use effect of opioid-free anesthesia (OFA) in obese patients undergoing laparoscopic sleeve gastrectomy on the quality of postoperative recovery.

METHODS: This prospective, parallel-group, double-blind, randomized controlled study included seventy-six patients undergoing laparoscopic sleeve gastrectomy in Beijing Friendship Hospital, Capital Medical University. Patients were randomly assigned to OFA group or opioid-based anesthesia (OBA) group. The primary outcome included the 15-item recovery quality scale (QOR-15). Secondary measures included intraoperative hemodynamic stability, intraoperative operation information, duration of until postoperative PACU Aldrete score > 9 points, anesthesia-related complication, and number of analgesic pump presses.

RESULTS: The scores of QOR-15 in OFA group were higher than that in OBA group at 24 h and 48 h after surgery. The total dose of propofol required in OFA group was statistically less than that in OBA group. Patients in the OBA group had significantly lower bispectral index (BIS) values and lower levels of MAP at T2 (after intubation) than those in the OFA group patients in the OBA group. Patients in the OFA group showed significantly lower levels of heart rate (HR) at T3 (after abdominal closure) when compared to the OBA group. The changing trend of visual analog scale (VAS) and OBAS scores recorded after surgery were similar between both groups and the VAS and Overall Benefit of Analgesia Scale (OBAS) scores in OBA group were obviously higher than those in OFA group in each time point. The Rhodes Index of Nausea and Vomiting in OBA group were obviously higher than those in OFA group in each time point.

CONCLUSIONS: OFA significantly improved postoperative recovery quality as evidenced by higher QOR-15 scores, reduced postoperative nausea and vomiting (PONV), lower pain scores and decreased opioid requirements compared to OBA. Although duration of awakening from anesthesia was prolonged, OFA demonstrated superior recovery outcomes and fewer complications supporting its clinical utility in obese patients undergoing laparoscopic sleeve gastrectomy.

PMID:40555931 | DOI:10.1007/s11695-025-08008-y

Geroscience. 2025 Jun 25. doi: 10.1007/s11357-025-01738-y. Online ahead of print.

ABSTRACT

Clinical care for patients with limited life expectancy often requires adjustments, prioritizing immediate benefits over long-term outcomes, as the relevance of future complications diminishes. This study identifies indicators of mortality risk in horses with chronic orthopaedic conditions to enhance individualized care and welfare. Over 3 years, 123 chronically lame horses and 6 healthy control horses at an animal sanctuary underwent regular (every 3 months) comprehensive health assessments and activity monitoring using wearable sensors. Data collected included body condition scores, musculoskeletal pain scores, lameness evaluations, and time budgets for eating, resting, and activity. Of the 123 chronically lame horses, 31 horses died (n = 31/123, 25.2%), with 10 succumbing to acute decompensation of their chronic condition (DAC, n = 10/123, 8.1%), while 21 were euthanized due to intractable pain or progressively deteriorating health and function (DCC, n = 21/123, 17.1%). Statistical modelling using death as outcome measure revealed body condition, pain scores, and time budget data to be strongly associated with equine mortality. Notably, low body condition score and reduced eating time predicted mortality in DAC horses, aligning with human studies linking weight loss to frailty and increased mortality risk. Additionally, depression-like behaviours were prevalent in DAC horses, mirroring the link between depression and mortality in humans. While pain scores were elevated in all deceased horses, weight loss was specific to DAC, suggesting multifactorial influences beyond pain. These findings provide a foundation for developing equine-specific tools to predict outcomes and guide clinical and end-of-life decisions, enabling individualized treatment to enhance the welfare and quality of life for aging horses. These insights may also offer valuable information for human medicine, particularly for at-risk groups such as individuals with cognitive impairments who may struggle to communicate their symptoms.

PMID:40555923 | DOI:10.1007/s11357-025-01738-y

Lifetime Data Anal. 2025 Jun 25. doi: 10.1007/s10985-025-09660-3. Online ahead of print.

ABSTRACT

We propose a joint model for multiple time-to-event outcomes where the outcomes have a cure structure. When a subset of a population is not susceptible to an event of interest, traditional survival models cannot accommodate this type of phenomenon. For example, for patients with melanoma, certain modern treatment options can reduce the mortality and relapse rates. Traditional survival models assume the entire population is at risk for the event of interest, i.e., has a non-zero hazard at all times. However, cure rate models allow a portion of the population to be risk-free of the event of interest. Our proposed model uses a novel truncated Gaussian copula to jointly model bivariate time-to-event outcomes of this type. In oncology studies, multiple time-to-event outcomes (e.g., overall survival and relapse-free or progression-free survival) are typically of interest. Therefore, multivariate methods to analyze time-to-event outcomes with a cure structure are potentially of great utility. We formulate a joint model directly on the time-to-event outcomes (i.e., unconditional on whether an individual is cured or not). Dependency between the time-to-event outcomes is modeled via the correlation matrix of the truncated Gaussian copula. A Markov Chain Monte Carlo procedure is proposed for model fitting. Simulation studies and a real data analysis using a melanoma clinical trial data are presented to illustrate the performance of the method and the proposed model is compared to independent models.

PMID:40555917 | DOI:10.1007/s10985-025-09660-3

Eur J Pediatr. 2025 Jun 24;184(7):437. doi: 10.1007/s00431-025-06275-6.

ABSTRACT

Bronchiolitis is a leading cause of hospitalization in infants, with RSV being the primary pathogen. In 2023, nirsevimab was approved for universal prophylaxis, demonstrating high effectiveness in reducing RSV-related hospitalizations. In Italy, nirsevimab was introduced in the vaccination schedule only during the current 2024-2025 epidemic season, with significant regional differences. In our region, Lazio, nirsevimab was introduced in late November 2024, leading only to a 43% overall reduction in RSV bronchiolitis hospitalizations compared to the previous season. The highest impact was observed in newborns immunized at birth (- 82.7%), while the catch-up group showed lower-than-expected benefits (- 29%). Immunized infants had significantly lower oxygen requirements (42.9% vs. 82.4% in non-immunized) and resulted to be approximately seven times more likely not to require oxygen compared to non-immunized patients.

CONCLUSION: Universal infant immunization against RSV marks a significant breakthrough in the natural history of bronchiolitis, and early and widespread nirsevimab administration appears to be crucial in minimizing RSV’s hospitalizations.

WHAT IS KNOWN: • Nirsevimab was approved in 2023 for the universal prophylaxis against RSV bronchiolitis. • Nirsevimab was was introduced in the Italian vaccination schedule only during the current 2024-2025 epidemic season, with significant regional differences.

WHAT IS NEW: • In Lazio, Italy, the delayed introduction of nirsevimab in November 2024 and the reduced vaccination coverage of the catch-up group resulted in a lower-than-expected reduction in RSV bronchiolitis hospitalizations. • Early and widespread administration of nirsevimab is crucial to maximizing its benefits and reducing severe RSV cases.

PMID:40555916 | DOI:10.1007/s00431-025-06275-6