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The relationships among stress-responsive biomarkers, ART adherence, and viral suppression among adolescent girls and young women living with HIV in South Africa: An HPTN 068 Analysis

J Acquir Immune Defic Syndr. 2022 Dec 12. doi: 10.1097/QAI.0000000000003149. Online ahead of print.

ABSTRACT

BACKGROUND: Adolescent girls and young women (AGYW) living with HIV who have higher stress levels may be at risk for stress-related biological alterations, which could influence HIV progression and adherence to antiretroviral therapy (ART).

SETTING: We aimed to estimate associations among stress-responsive biomarkers, ART adherence and viral suppression in AGYW living with HIV in South Africa. We also hypothesized that psychosocial stressors (e.g., depression, food insecurity, low socioeconomic status (SES), HSV-2) would be associated with higher biomarker levels.

METHODS: We utilized 2018/2019 data from the HIV Prevention Trials Network (HPTN) 068 cohort to assess associations between stress-responsive biomarkers and viral suppression (<1000 copies/mL) and ART adherence measured using dried blood spot (DBS) cards. Stress-responsive biomarkers included C-reactive protein (CRP), Herpes simplex virus type 1 (HSV-1), and cytomegalovirus (CMV) infection and reactivation. Associations were estimated using unadjusted log-binomial or ordinal logistic regression models.

RESULTS: In 166 AGYW living with HIV, there was no association between stress-responsive biomarkers and viral suppression or ART adherence. However, increased CRP levels were associated with higher HSV-2 infection (odds ratio (OR) 1.98; 95% confidence interval (CI) 1.11, 3.52), being a government grant recipient (OR 3.21; 95% CI 1.30, 7.92), lower food insecurity (OR 0.34; 95% CI 0.13, 0.90) and increased BMI (OR 1.07; 95% CI 1.01, 1.14).

CONCLUSIONS: High prevalence of psychosocial stressors and persistent herpesviruses in AGYW living with HIV has the potential to lead to poorer health outcomes. More research is needed to untangle relationships between economic stability, chronic disease, and chronic stress.

PMID:36729676 | DOI:10.1097/QAI.0000000000003149

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Auditory Function in the Pediatric HIV/AIDS Cohort Study Adolescent Master Protocol (AMP) Up Young Adults: A Pilot Study

J Acquir Immune Defic Syndr. 2022 Dec 12. doi: 10.1097/QAI.0000000000003145. Online ahead of print.

ABSTRACT

BACKGROUND: To collect and compare selected hearing measures in a pilot study of young adults with perinatally-acquired HIV (YAPHIV), and those with perinatal HIV-exposure, who are uninfected (YAPHEU).

SETTING: Cross-sectional hearing measures in YAPHIV and YAPHEU enrolled in the Pediatric HIV/AIDS Cohort Study (PHACS) Adolescent Master Protocol (AMP) for Participants 18 Years of Age and Older (AMP Up).

METHODS: Pure-tone air conduction audiometry and distortion product otoacoustic emission (DPOAE) data were collected in one visit. A low-frequency pure-tone average (PTA) (LFPTA, at 0.25, 0.5, 1, and 2 kHz), a speech-frequency PTA (SFPTA, at 0.5, 1, 2, and 4 kHz), and a high-frequency PTA (HFPTA, at 3, 4, 6, and 8 kHz) were calculated. Hearing loss was defined as worse ear SFPTA ≥20 dB HL. Separate linear regression models were fit for worse ear LFPTA, SFPTA, and HFPTA to assess associations with PHIV status. DPOAE signal-to-noise ratios (SNRs) were obtained at three frequencies in each ear.

RESULTS: Forty-seven YAPHIV and 9 YAPHEU completed hearing testing. All adjusted mean PTAs were similar between YAPHIV and YAPHEU. Hearing loss occurred more in YAPHIV (7/47, 15.2%, 95% CI: 6.3%-28.9%), compared to YAPHEU (0/9, 0%). No associations were detected between HIV disease severity measures and worse ear SFPTA. DPOAE SNRs were similar between YAPHIV and YAPHEU.

CONCLUSIONS: In this pilot study, peripheral hearing (i.e., PTAs) and cochlear function (i.e., DPOAEs) were similar between YAPHIV and YAPHEU. A larger study is warranted to confirm these findings.

PMID:36729663 | DOI:10.1097/QAI.0000000000003145

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Prospective In Vitro Comparison of Kerasave and Optisol-GS Corneal Storage Solutions

Cornea. 2022 Dec 13. doi: 10.1097/ICO.0000000000003201. Online ahead of print.

ABSTRACT

PURPOSE: The aim of this study was to compare the performance of Kerasave and Optisol-GS for hypothermic corneal storage for 14 days.

METHODS: This study was a prospective laboratory investigation. Mate corneas were recovered into Kerasave or Optisol-GS (27 pairs) and stored at 2°C to 8°C for 14 days. Corneas were evaluated by trained eye bank technicians, and study parameters were compared between the initial and final evaluations. Endothelial cell density (ECD), hexagonality (HEX), and coefficient of variation (CV) were evaluated by specular microscopy, and central corneal thickness (CCT) was examined by optical coherence tomography after 1, 3, 7, and 14 days of storage. Corneal transparency was scored using slit lamp examination at days 1 and 14.

RESULTS: Average ECD, HEX, and CV for the Kerasave (2653 ± 303 cells/mm2, 57 ± 4%, and 36 ± 3%) and Optisol-GS (2623 ± 306 cells/mm2, 57 ± 5%, and 36 ± 4%) groups were not significantly different at day 1. There was also no difference at any other study time points (all P > 0.05). ECD did not significantly change from day 1 to day 14 in either group (P > 0.05), but a statistically significant change in HEX and CV was observed between day 1 and day 14 in both groups (P < 0.01). Average CCT measured at day 1 for corneas stored in Kerasave was 622 ± 49 μm and those stored in Optisol-GS was 580 ± 35 μm (P < 0.01). The difference in CCT measurements was not significantly different at day 14 (Kerasave: 674 ± 46 μm vs. Optisol-GS: 647 ± 58 μm, P > 0.05). Corneal transparency was not significantly different between the 2 groups at day 1 or day 14.

CONCLUSIONS: The corneal quality and clinically relevant parameters including ECD, endothelial morphometry, and corneal transparency were not different in corneas stored in Kerasave or Optisol-GS for 14 days. The initial difference in CCT between the 2 groups decreased at day 14. These results demonstrated that Kerasave corneal storage solution preserves the corneal endothelium similarly to Optisol-GS.

PMID:36729660 | DOI:10.1097/ICO.0000000000003201

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Assessing Medial Olivocochlear Reflex Strengths via Auditory Brainstem Response: Measurement and Variability in Normal-Hearing Individuals

Am J Audiol. 2023 Feb 2:1-12. doi: 10.1044/2022_AJA-22-00119. Online ahead of print.

ABSTRACT

PURPOSE: Optimal measurement settings to measure the medial olivocochlear reflex (MOCR) in humans have not yet been defined. The purpose of this study was to advance the representation of the MOCR in auditory brainstem response (ABR) as an addition to the current diagnostic portfolio.

PARTICIPANTS AND METHOD: Twelve female and 14 male normal-hearing adults participated in the study. Potential effects of a contralateral acoustic stimulus (CAS) on amplitude changes were investigated by recording ABR waveform profiles on the left side at click intensities of 50/60/70 dB nHL with and without CAS (60 dB SPL). Secondly, to detect potential chronological order influences, measurement settings were rearranged on the right side and measurements were repeated. Additionally, ABR thresholds were recorded with and without a CAS in 10 patients.

RESULTS: When the effect of contralateral suppression was analyzed on the basis of amplitude changes, there was a change under administration of the CAS signal that was statistically significant. Interestingly, the order of recordings affected the degree of amplitude change. In three out of 10 patients, reproducible suppression effects on ABR thresholds were detectable upon CAS presentation.

CONCLUSIONS: To our knowledge, this is the largest study dealing with the recording of the MOCR elicited by a contralateral noise via ABR in normal-hearing individuals. Effects of MOCR are measurable via amplitude changes upon CAS administration. Chronological orders influence the impact of this effect on amplitude changes. Optimal measurement settings have not yet been defined. However, experiments such as this study may help to further improve measurements, and thus advance the representation of the MOC reflex in ABR as an addition to the current diagnostic portfolio.

PMID:36729649 | DOI:10.1044/2022_AJA-22-00119

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Cross-Linking Improves the Quality of Life of People With Keratoconus: A Cross-Sectional and Longitudinal Study From the Save Sight Keratoconus Registry

Cornea. 2022 Dec 13. doi: 10.1097/ICO.0000000000003185. Online ahead of print.

ABSTRACT

PURPOSE: The purpose of this study was to comprehensively evaluate the patient-reported quality-of-life (QoL) outcomes after corneal cross-linking for keratoconus.

METHODS: This Save Sight Keratoconus Registry study used cross-sectional and longitudinal designs. For the cross-sectional study, 532 patients with keratoconus (mean age 30.9 ± 11.9 years; 31.6% female) completed the Keratoconus Outcomes Research Questionnaire (KORQ) and 343 patients with keratoconus (mean age 28.3 ± 10.7 years; 32.7% female) completed the Impact of Vision Impairment (IVI) questionnaires. Similarly, for the longitudinal study, 39 patients (mean age 24.2 ± 8.4 years; 23.1% female) completed the KORQ and 16 patients (mean age 27.9 ± 17.1 years; 50.0% female) completed the IVI questionnaire before and after 6 months of cross-linking. The QoL data were analyzed using the Andrich Rating Scale Model of Rasch analysis.

RESULTS: For both cross-sectional and longitudinal studies, the KORQ and IVI scales demonstrated satisfactory psychometric properties [ordered and well-spaced categories, variance explained by the measure 52%-73%, person separation index 2.4-3.9, and fit statistics <1.3 (most cases)]. The patients who had not undergone corneal cross-linking had worse mean activity limitation than those with cross-linking (P = 0.008). However, the differences in symptoms and emotional scores between the groups were not statistically significant (both P > 0.05). The longitudinal study showed that cross-linking was associated with improved activity limitation, symptoms, and emotional scores.

CONCLUSIONS: The KORQ and IVI are psychometrically robust tools to evaluate the QoL outcomes of corneal cross-linking. Cross-linking is associated with improved activity limitation, symptoms, and emotional status.

PMID:36729643 | DOI:10.1097/ICO.0000000000003185

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Effects of Sex and Cuff Pressure on Physiological Responses during Blood Flow Restriction Resistance Exercise in Young Adults

Med Sci Sports Exerc. 2022 Dec 14. doi: 10.1249/MSS.0000000000003103. Online ahead of print.

ABSTRACT

PURPOSE: The purpose was to examine the physiological responses resulting from an acute blood flow restriction (BFR) resistance exercise bout with two different cuff pressures in young, healthy men and women.

METHODS: Thirty adults (18-30 yr) completed a bilateral leg extension BFR bout consisting of four sets (30-15-15-15 repetitions) with cuffs applied at pressures corresponding to 40% and 60% of the minimum arterial occlusion pressure (AOP) needed to completely collapse the femoral arteries. During each of these conditions (40% and 60% AOP), physiological measures of near-infrared spectroscopy (NIRS) and electromyographic amplitude (EMG AMP) were collected from the dominant or non-dominant vastus lateralis. After each set, ratings of perceived exertion (RPE) were collected, whereas only at baseline and at the end of the bout, mean arterial pressure (MAP) was assessed. Separate mixed-factorial ANOVAs were used to examine mean differences in the change in EMG AMP and NIRS-parameters during each set. The absolute RPE and MAP values were also examined with separate ANOVAs. A p-value ≤0.05 was considered statistically significant.

RESULTS: Regardless of sex or cuff pressure, the change in EMG amplitude was lower in set 1 (14.8%) compared to the remaining sets (22.6 – 27.0%). The 40% AOP condition elicited the greatest changes in oxy[heme] and deoxy[heme], while also providing lower RPEs. For MAP there was an effect for Time such that MAP increased from pre (87.5 ± 4.3 mmHg) to post-exercise (104.5 ± 4.1 mmHg).

CONCLUSIONS: The major findings suggested that the 40% AOP condition permitted the greatest amount of recovery during the inter-set rest. Additionally, there did not appear to be any meaningful sex-related difference in this sample of young healthy adults.

PMID:36729632 | DOI:10.1249/MSS.0000000000003103

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Added Value of Extragenital STI testing in “I Want The Kit” Program Users

Sex Transm Dis. 2022 Dec 14. doi: 10.1097/OLQ.0000000000001743. Online ahead of print.

ABSTRACT

BACKGROUND: The 2021 CDC STI treatment guidelines recommend extragenital testing for gonorrhea and chlamydia in men who have sex with men (MSM) and for women based on reported behaviors and exposures. The “IWantTheKit (IWTK)” program is a free online platform for specimen self-collection and mail-in for combined chlamydia/gonorrhea testing. We sought to assess the additional diagnostic value of extragenital testing compared to genital testing only for chlamydia/gonorrhea and determine factors associated with a positive extragenital test among IWTK users.

METHODS: From August 2013 to January 2022, 7,612 unique IWTK users returned swabs for testing; 3,407 (45%) users requested both genital and extragenital tests and were included in this analysis. Descriptive statistics summarized demographic characteristics, reported behaviors, and genital and extragenital test results, data were stratified by gender and age group. A logistic regression model was used to estimate associations between factors and extragenital STI positivity.

RESULTS: Chlamydia positivity was 4.7%, 2.4% and 1.5% at genital, extragenital and both sites were positive, respectively; for gonorrhea, 0.4%, 1.1% and 0.4% were positive at those sites, respectively. Among women, age 25 and younger was significantly associated with extragenital chlamydia, OR = 4.0 (p = 0.010). Being in high risk quiz score group was associated with extragenital chlamydia (OR = 2.6, p = 0.005), and extragenital gonorrhea in men and women (OR = 8.5, p = 0.005).

CONCLUSION: Extragenital testing detected additional chlamydia and gonorrhea cases in the IWTK user population that would have been missed by genital only testing, especially for females <25 years and people reported high risk.

PMID:36729630 | DOI:10.1097/OLQ.0000000000001743

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Five-year follow-up of an interdisciplinary oral health education program: Clinical practice behaviors in working pediatric nurse practitioners

J Am Assoc Nurse Pract. 2022 Dec 14. doi: 10.1097/JXX.0000000000000809. Online ahead of print.

ABSTRACT

Many interdisciplinary oral health education programs have been implemented for pediatric primary care providers (e.g., pediatric nurse practitioner [PNP]) to raise awareness and gain skills related to the prevention of early childhood caries (ECC). However, no studies have evaluated if these educational programs provided to PNPs during their training resulted in clinical practice behavior changes. A 33-item survey was designed on a web-based platform (Survey Monkey) and distributed to 71 PNP graduates. The survey included demographics, current clinical practice, clinical practice behaviors, and perceived barriers to practice. Descriptive statistics were used to assess the survey items and thematic analyses on the open-ended questions. The survey response rate was 70% (50/71 PNPs). Most practicing PNPs were in acute care or specialty clinics (n = 33; 66%) where oral health was not part of the focused visit. Majority used knowledge learned in assessment and anticipatory guidance skills. However, only 14% of primary care providers were applying fluoride varnish with 10% billing for this procedure. Barriers to application were time, available supplies, COVID protocols, lack of support staff, or not billing due to minimal reimbursement. Many primary care-trained PNPs were practicing in acute or subspecialty areas where prevention of ECC is not viewed as part of their focused visit. Pediatric nurse practitioners working in primary care demonstrated some clinical practice changes. However, areas for improvement are time to perform a risk assessment and application of fluoride varnish, access to these supplies, and standard billing and insurance reimbursement for these preventable services.

PMID:36729598 | DOI:10.1097/JXX.0000000000000809

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The Impact of Underlying Obstructive Sleep Apnea Treatment on Exercise Capacity in Patients With Pulmonary Hypertension Undergoing a Cardiac Rehabilitation Program

J Cardiopulm Rehabil Prev. 2022 Dec 14. doi: 10.1097/HCR.0000000000000745. Online ahead of print.

ABSTRACT

PURPOSE: Obstructive sleep apnea (OSA)-related pulmonary hypertension (PH) can often be reversed with treatment of OSA via continuous positive airway pressure. We hypothesized that treatment of OSA would be associated with a greater improvement in exercise capacity (EC) with cardiac rehabilitation (CR), especially in patients with PH as compared with those who are untreated.

METHODS: We reviewed medical records of 315 consecutive patients who participated in CR. Pulmonary hypertension status was assessed on the basis of peak tricuspid regurgitant velocity (>2.8 m/sec) on pre-CR echocardiograms. The OSA status (no, untreated, or treated OSA) was determined on the basis of results from sleep studies, continuous positive airway pressure device data, and physician notes. Exercise capacity was assessed by measuring metabolic equivalents (METs) using a treadmill stress test before and after CR.

RESULTS: We included 290 patients who participated in CR with available echocardiographic data: 44 (15%) had PH, and 102 (35%) had known OSA (30 treated and 72 untreated). Patients with OSA versus those with no OSA were more likely to have PH (P = .06). Patients with PH versus no-PH were associated with significantly lower baseline METs in crude and adjusted analyses (P ≤. 004). The PH and OSA status in isolation were not associated with changes in METs (P > .2) with CR. There was a significant interaction between OSA treatment and PH in crude and adjusted analyses (P ≤.01): treatment vs no treatment of OSA was associated with a clinically and statistically greater improvement in METs in patients who participated in CR with but not without PH.

CONCLUSION: Baseline PH was associated with decreased baseline EC but did not attenuate CR-related improvements in METs. However, in the subset of OSA patients with PH, OSA therapy was associated with improved EC after CR.

PMID:36729594 | DOI:10.1097/HCR.0000000000000745

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The Price-Quality Mismatch: Are Negotiated Prices for Total Joint Arthroplasty Associated With Hospital Quality in a Large California Health System?

Clin Orthop Relat Res. 2022 Dec 13. doi: 10.1097/CORR.0000000000002489. Online ahead of print.

ABSTRACT

BACKGROUND: Price variations in healthcare can be caused by quality or factors other than quality such as market share, negotiating power with insurers, or hospital ownership model. Efforts to improve care value (defined as the ratio between health outcomes and price) by making healthcare prices readily accessible to patients are driven by the assumption this can help patients more easily identify high-quality, low-price clinicians and health systems, thus reducing price variations. However, if price variations are driven by factors other than quality, then strategies that involve payments for higher-quality care are unlikely to reduce price variation and improve value. It is unknown whether prices for total joint arthroplasty (TJA) are correlated with the quality of care or whether factors other than quality are responsible for price variation.

QUESTIONS/PURPOSES: (1) How do prices insurers negotiate for TJA paid to a single, large health system vary across payer types? (2) Are the mean prices insurers negotiate for TJA associated with hospital quality?

METHODS: We analyzed publicly available data from 22 hospitals in a single, large regional health system, four of which were excluded owing to incomplete quality information. We chose to use data from this single health system to minimize the confounding effects of between-hospital reputation or branding and geographic differences in the cost of providing care. This health system consists of large and small hospitals serving urban and rural populations, providing care for more than 3 million individuals. For each hospital, negotiated prices for TJA were classified into five payer types: commercial in-network, commercial out-of-network, Medicare Advantage (plans to which private insurers contract to provide Medicare benefits), Medicaid, and discounted cash pay. Traditional Medicare plans were not included because the prices are set statutorily, not negotiated. We obtained hospital quality measures from the Centers for Medicare and Medicaid Services. Centers for Medicare and Medicaid Services quality measures included TJA-specific complication and readmission rates in addition to hospital-wide patient survey star rating (measure of patient care experience) and total performance scores (aggregate measure of clinical outcomes, safety, patient experience, process of care, and efficiency). We evaluated the association between the mean negotiated hospital prices and Centers for Medicare and Medicaid Services quality measures using Pearson correlation coefficients and Spearman rho across all payer types. Statistical significance was defined as p < 0.0025.

RESULTS: The mean ± SD overall negotiated price for TJA was USD 54,500 ± 23,200. In the descriptive analysis, the lowest negotiated prices were associated with Medicare Advantage (USD 20,400 ± 1800) and Medicaid (USD 20,300 ± 8600) insurance plans, and the highest prices were associated with out-of-network care covered by commercial insurance plans (USD 78,800 ± 9200). There was no correlation between the mean negotiated price and TJA complication rate (discounted cash price: r = 0.27, p = 0.29; commercial out-of-network: r = 0.28, p = 0.26; commercial in-network: r = -0.07, p = 0.79; Medicare Advantage: r = 0.11, p = 0.65; Medicaid: r = 0.03, p = 0.92), readmission rate (discounted cash price: r = 0.19, p = 0.46; commercial out-of-network: r = 0.24, p = 0.33; commercial in-network: r = -0.13, p = 0.61; Medicare Advantage: r = -0.06, p = 0.81; Medicaid: r = 0.09, p = 0.74), patient survey star rating (discounted cash price: r = -0.55, p = 0.02; commercial out-of-network: r = -0.53, p = 0.02; commercial in-network: r = -0.37, p = 0.13; Medicare Advantage: r = -0.08, p = 0.75; Medicaid: r = -0.02, p = 0.95), or total hospital performance score (discounted cash price: r = -0.35, p = 0.15; commercial out-of-network: r = -0.55, p = 0.02; commercial in-network: r = -0.53, p = 0.02; Medicare Advantage: r = -0.28, p = 0.25; Medicaid: r = 0.11, p = 0.69) for any of the payer types evaluated.

CONCLUSION: There is substantial price variation for TJA that is not accounted for by the quality of care, suggesting that a mismatch between price and quality exists. Efforts to improve care value in TJA are needed to directly link prices with the quality of care delivered, such as through matched quality and price reporting mechanisms. Future studies might investigate whether making price and quality data accessible to patients, such as through value dashboards that report easy-to-interpret quality data alongside price information, moves patients toward higher-value care decisions.

CLINICAL RELEVANCE: Efforts to better match the quality of care with negotiated prices such as matched quality and price reporting mechanisms, which have been shown to increase the likelihood of choosing higher-value care in TJA, could improve the value of care.

PMID:36729581 | DOI:10.1097/CORR.0000000000002489