Category: Nevin Manimala

Biol Psychiatry. 2022 Dec 23:S0006-3223(22)01852-2. doi: 10.1016/j.biopsych.2022.12.018. Online ahead of print.

ABSTRACT

BACKGROUND: Neuroimaging studies of functional connectivity (FC) in autism have been hampered by small sample sizes and inconsistent findings with regard to whether connectivity is increased or decreased in individuals with autism, whether these alterations affect focal systems or reflect a brain-wide pattern, and whether these are age and/or sex dependent.

METHODS: The study included resting-state functional magnetic resonance imaging and clinical data from the EU-AIMS LEAP (European Autism Interventions Longitudinal European Autism Project) and the ABIDE (Autism Brain Imaging Data Exchange) 1 and 2 initiatives of 1824 (796 with autism) participants with an age range of 5-58 years. Between-group differences in FC were assessed, and associations between FC and clinical symptom ratings were investigated through canonical correlation analysis.

RESULTS: Autism was associated with a brainwide pattern of hypo- and hyperconnectivity. Hypoconnectivity predominantly affected sensory and higher-order attentional networks and correlated with social impairments, restrictive and repetitive behavior, and sensory processing. Hyperconnectivity was observed primarily between the default mode network and the rest of the brain and between cortical and subcortical systems. This pattern was strongly associated with social impairments and sensory processing. Interactions between diagnosis and age or sex were not statistically significant.

CONCLUSIONS: The FC alterations observed, which primarily involve hypoconnectivity of primary sensory and attention networks and hyperconnectivity of the default mode network and subcortex with the rest of the brain, do not appear to be age or sex dependent and correlate with clinical dimensions of social difficulties, restrictive and repetitive behaviors, and alterations in sensory processing. These findings suggest that the observed connectivity alterations are stable, trait-like features of autism that are related to the main symptom domains of the condition.

PMID:36925414 | DOI:10.1016/j.biopsych.2022.12.018

J Adolesc Health. 2023 Mar 14:S1054-139X(23)00058-7. doi: 10.1016/j.jadohealth.2023.01.011. Online ahead of print.

ABSTRACT

PURPOSE: The human papillomavirus (HPV) causes genitourinary and oropharyngeal cancers. The HPV vaccine is safe and effective in preventing those diseases; however, vaccine series completion rates remain low in the United States. Our quality improvement (QI) project aimed to increase HPV-vaccination series completion rates to 70% from 2017 to 2020 for the 13-year patient population in an extensive academic pediatric primary care network that serves predominantly minority and Medicaid-insured children in Columbus, OH.

METHODS: The outcome measure was the percentage of 13-years Nationwide Children’s Hospital Primary Care Network patients who completed the two-dose vaccine series by their 13th birthday. Four QI implemented interventions were utilized. Electronic medical records alert informed providers when the HPV vaccines are due. We studied monthly data for the network and for individual clinics using statistical process control, displaying data on a control chart. We followed two process measures, captured opportunity rate, and the number of HPV vaccines given.

RESULTS: We substantially increased HPV-vaccination series completion rates overall in the 13-year teen population from 27% to 65%, and three clinics reached the 70% goal for at least one quarter. Latino children had the highest completion rate of 80% and White children had the lowest completion rate at 64%.

DISCUSSION: Our QI project used four measures to improve HPV-vaccination series completion rates in the 13-year patient population that serves minority and low-income teens predominantly. Further QI studies are needed to improve HPV vaccine completion rates in teens.

PMID:36925411 | DOI:10.1016/j.jadohealth.2023.01.011

J Voice. 2023 Mar 14:S0892-1997(23)00067-X. doi: 10.1016/j.jvoice.2023.02.012. Online ahead of print.

ABSTRACT

OBJECTIVES: To investigate the added value of steroid injection following office-based blue laser therapy of benign lesions of the vocal folds.

STUDY DESIGN: Retrospective cohort analysis.

METHODS: The medical records and video-recordings of patients with benign lesions of the vocal folds who underwent office-based blue laser therapy in a tertiary referral center between February 2020 and October 2022 were reviewed. Patients were divided into two subgroups, those who underwent office-based blue laser therapy alone (n = 23) and those who underwent office-based blue laser therapy with steroid injection (n = 19). Disease regression and voice outcome measures included Voice Handicap Index-10 score, perceptual voice evaluation using the GRB grading, jitter, shimmer, noise to harmonic ratio, voice turbulence index, and maximum phonation time were reviewed.

RESULTS: A total of 42 patients were included. The mean age was 54.7 ± 10.1 years. Lesions included polyps (n = 21), Reinke’s edema (n = 19), and cysts (n = 2). There was partial or complete disease regression in all patients who presented for follow-up (n = 37). In patients who underwent blue laser therapy alone (n = 19), 42.1% had complete regression and 57.9% had partial regression. In those who underwent blue laser therapy followed by steroid injection (n = 18), 77.7% had complete disease regression and 22.3% had partial regression. The difference in disease regression between the two subgroups was statistically significant (P = 0.027). The decrease in the mean Voice Handicap Index-10 score was also statistically significant with a higher mean being noted in the subgroup who underwent blue laser therapy followed by steroid injection (-10.5 ± 6.9 vs. -17.3 ± 11.8, P = 0.031). There was no significant difference in the decrease in the perceptual evaluation scores nor in the decrease in jitter, shimmer, noise to harmonic ratio, and voice turbulence index between the two subgroups. There was also no significant increase in the maximum phonation time.

CONCLUSION: Steroid injection after blue laser therapy improves disease regression and voice outcome of laser therapy.

PMID:36925408 | DOI:10.1016/j.jvoice.2023.02.012

J Heart Lung Transplant. 2023 Feb 20:S1053-2498(23)00049-9. doi: 10.1016/j.healun.2023.02.006. Online ahead of print.

ABSTRACT

BACKGROUND: Existing measures of frailty developed in community dwelling older adults may misclassify frailty in lung transplant candidates. We aimed to develop a novel frailty scale for lung transplantation with improved performance characteristics.

METHODS: We measured the short physical performance battery (SPPB), fried frailty phenotype (FFP), Body Composition, and serum Biomarkers representative of putative frailty mechanisms. We applied a 4-step established approach (identify frailty domain variable bivariate associations with the outcome of waitlist delisting or death; build models sequentially incorporating variables from each frailty domain cluster; retain variables that improved model performance ability by c-statistic or AIC) to develop 3 candidate “Lung Transplant Frailty Scale (LT-FS)” measures: 1 incorporating readily available clinical data; 1 adding muscle mass, and 1 adding muscle mass and research-grade Biomarkers. We compared construct and predictive validity of LT-FS models to the SPPB and FFP by ANOVA, ANCOVA, and Cox proportional-hazard modeling.

RESULTS: In 342 lung transplant candidates, LT-FS models exhibited superior construct and predictive validity compared to the SPPB and FFP. The addition of muscle mass and Biomarkers improved model performance. Frailty by all measures was associated with waitlist disability, poorer HRQL, and waitlist delisting/death. LT-FS models exhibited stronger associations with waitlist delisting/death than SPPB or FFP (C-statistic range: 0.73-0.78 vs. 0.57 and 0.55 for SPPB and FFP, respectively). Compared to SPPB and FFP, LT-FS models were generally more strongly associated with delisting/death and improved delisting/death net reclassification, with greater improvements with increasing LT-FS model complexity (range: 0.11-0.34). For example, LT-FS-Body Composition hazard ratio for delisting/death: 6.0 (95%CI: 2.5, 14.2), SPPB HR: 2.5 (95%CI: 1.1, 5.8), FFP HR: 4.3 (95%CI: 1.8, 10.1). Pre-transplant LT-FS frailty, but not SPPB or FFP, was associated with mortality after transplant.

CONCLUSIONS: The LT-FS is a disease-specific physical frailty measure with face and construct validity that has superior predictive validity over established measures.

PMID:36925382 | DOI:10.1016/j.healun.2023.02.006

Injury. 2023 Feb 27:S0020-1383(23)00182-1. doi: 10.1016/j.injury.2023.02.051. Online ahead of print.

ABSTRACT

BACKGROUND: Kenya’s estimated road traffic injury (RTI) death rate is 27.8/100,000 population, which is 1.5 times the global rate. Some RTI data are collected in Kenya; however, a systematic and integrated surveillance system does not exist. Therefore, we adopted and modified the World Health Organization’s injury surveillance guidelines to pilot a hospital-based RTI surveillance system in Nairobi County, Kenya.

METHODS: We prospectively documented all RTI cases presenting at two public trauma hospitals in Nairobi County from October 2018-April 2019. RTI cases were defined as injuries involving ≥1 moving vehicles on public roads. Demographics, injury circumstances, and outcome information were collected using standardized case report forms. The Kampala Trauma Score (KTS) was used to assess injury severity. RTI cases were characterized with descriptive statistics.

RESULTS: Of the 1,840 RTI cases reported during the seven-month period, 73.2% were male. The median age was 29.8 years (range 1-89 years). Forty percent (n = 740) were taken to the hospital by bystanders. Median time for hospital arrival was 77 min. Pedestrians constituted 54.1% (n = 995) of cases. Of 400 motorcyclists, 48.0% lacked helmets. Similarly, 65.7% of bicyclists (23/35) lacked helmets. Among 386 motor vehicle occupants, 59.6% were not using seat belts (19.9% unknown). Seven percent of cases (n = 129) reported alcohol use (49.0% unknown), and 8.8% (n = 161) reported mobile phone use (59.7% unknown). Eleven percent of cases (n = 199) were severely injured (KTS <11), and 220 died.

CONCLUSION: We demonstrated feasibility of a hospital-based RTI surveillance system in Nairobi County. Integrating information from crash scenes and hospitals can guide prevention.

PMID:36925372 | DOI:10.1016/j.injury.2023.02.051

Public Health. 2023 Feb 1:S0033-3506(23)00032-X. doi: 10.1016/j.puhe.2023.01.023. Online ahead of print.

NO ABSTRACT

PMID:36925371 | DOI:10.1016/j.puhe.2023.01.023

Int J Oral Maxillofac Surg. 2023 Mar 14:S0901-5027(23)00044-9. doi: 10.1016/j.ijom.2023.01.021. Online ahead of print.

ABSTRACT

The purpose of this study was to review the existing evidence from randomized controlled trials (RCTs) on the effect of autogenous bone grafts combined with a platelet-rich concentrate on alveolar clefts. An electronic search was conducted in the PubMed/MEDLINE, Cochrane Central Register of Controlled Trials, Embase, and ClinicalTrials.gov databases for studies published between January 2000 and April 2022. This study included six RCTs to evaluate bone quantity (bone formation ratio, %) and quality (bone density in Hounsfield units, HU), as well as complications as a way to assess the safety of the technique. Two independent reviewers assessed the risk of bias. There was no statistically significant difference in bone formation ratio at 6 months of follow-up between the use of autologous bone alone for alveolar bone grafting or adding platelet-rich plasma (PRP) (mean difference (MD) 14.33%, 95% confidence interval (CI) – 7.19% to 35.85%; P = 0.196) or platelet-rich fibrin (PRF) (MD 9.38%, 95% CI -2.36% to 21.12%; P = 0.123) to autologous bone. The MD for the change in bone density at 6 months was in favour of PRP added to autologous bone graft (MD 155.69 HU, 95% CI 99.29-212.09 HU; P < 0.001); however, this result was based on only two studies, one of which had a high risk of bias. Patients who received autologous bone graft with PRP were significantly less likely to experience complications (odds ratio (OR) 0.21, 95% CI 0.05-0.92; P = 0.038), but this was no longer statistically significant after a sensitivity test (OR 0.24, 95% CI 0.04-1.56; P = 0.138). In conclusion, this systematic review and meta-analysis appears to show no benefit to using a platelet-rich concentrate combined with autologous bone for alveolar cleft grafting in terms of bone volume, bone density, or complications.

PMID:36925370 | DOI:10.1016/j.ijom.2023.01.021

Comput Biol Chem. 2023 Mar 3:107847. doi: 10.1016/j.compbiolchem.2023.107847. Online ahead of print.

NO ABSTRACT

PMID:36925366 | DOI:10.1016/j.compbiolchem.2023.107847

Curr Pharm Teach Learn. 2023 Mar 14:S1877-1297(23)00003-5. doi: 10.1016/j.cptl.2023.02.003. Online ahead of print.

ABSTRACT

INTRODUCTION: The University of Texas at Austin College of Pharmacy transitioned the prospective student interview process for the incoming Class of 2025 from an onsite to a virtual Zoom interview. Differences between the two processes were assessed to determine utility of virtual interviews in the future. The objective was to compare preference, impact, and barriers to onsite and virtual interview experiences for prospective students.

METHODS: A survey to assess interviewees’ opinions regarding the interview process, preference, and barriers to participation was emailed to candidates following the 2020-2021 interviews. Responses were evaluated using descriptive statistics, chi-square, Mann-Whitney U tests, and constant comparison thematic analysis.

RESULTS: The survey response rate was 40%. Of these, 54% preferred virtual interviews. Travel, lodging, and time were identified as barriers, with 80.5% of interviewees reporting at least one of these barriers. Respondents who chose time or had more barriers were more likely to prefer virtual interviews. Hosting a pre-interview day helped candidates prepare. Having a pharmacy student in the breakout room helped reduce stress. Interviewees were able to engage, showcase their personality, and learn the culture of the college despite the virtual nature.

CONCLUSIONS: From an interviewee perspective, the virtual interview process is a viable method to continue. Virtual interviews decrease barriers to access for candidates unable to attend onsite interviews while still allowing candidates to feel engaged, learn about the program, and have a positive experience. Pharmacy institutions may consider virtual interviews as an alternative or supplement to onsite interviews.

PMID:36925363 | DOI:10.1016/j.cptl.2023.02.003

Arch Pediatr. 2023 Mar 14:S0929-693X(22)00243-3. doi: 10.1016/j.arcped.2022.11.018. Online ahead of print.

ABSTRACT

OBJECTIVE: Children’s responses to food and their caregivers during normal developmental periods are known as feeding behavior. For the healthy development of these behaviors, parent and child relationships must also be healthy. Therefore, we aimed to investigate the effect of behavioral feeding problems on primary malnutrition (PM).

METHOD: The Behavioral Pediatric Nutrition Assessment Scale (BPFAS) was administered to 300 malnourished and 300 control pediatric patients aged from 9 months to 4 years who were referred to our pediatric gastroenterology outpatient clinic. Pre- and posttreatment data were compared between the two groups.

RESULTS: There was no statistically significant difference between patients with and without malnutrition in terms of gender and age (p = 0.191, p = 0.128, respectively). Total behavioral frequency (TBF) and total behavioral problem (TBP) scores were significantly higher in the malnutrition group (p < 0.001). In the logistic regression analysis of risk factors that may affect malnutrition we found that a total TBF score of ≥85 increases the risk of developing malnutrition 3.731 times, a child TBF score of ≥62 increases it 2.644 times, and a parental TBF score of ≥21 increases it 4.82 times (p < 0.001). When anthropometric measurements and BPFAS scores of 127 PM patients who received behavioral therapy with enteral products and who attended follow-up were compared with their pretreatment data, there was a significant improvement (p < 0.05).

CONCLUSION: Our study showed that behavioral feeding problems may increase the risk of PM and that behavioral therapy together with enteral products has a positive effect on treatment. Therefore, in addition to nutritional support in patients with PM, offering behavioral feeding therapy to parents will positively affect both the child’s physical development and the relationship between the parents and their child.

PMID:36925345 | DOI:10.1016/j.arcped.2022.11.018