Category: Nevin Manimala

Environ Sci Pollut Res Int. 2023 Apr 5. doi: 10.1007/s11356-023-26706-x. Online ahead of print.

ABSTRACT

Tanacetum parthenium L. is a popular traditional medicinal plant that the role of presence of particular phytochemical compounds are still unconsidered particularly in the bio-nano researches. Here, for the first time, the green fabrication of CuO NPs using Tanacetum parthenium L. extract was performed and assessed for the antimicrobial, cytotoxicity, and dye degradation activities. Characterization of CuO NPs was done by UV-visible spectra, XRD, FT-IR, TEM, and EDX. The synthesized CuO NPs possess a crystalline nature, a functional group that resembles T. parthenium, with a spherical shape particle with an average size of 28 nm. EDX confirmed CuO NPs formation. The CuO NPs showed excellent antimicrobial activity against tested microorganisms. The cytotoxicity of CuO NPs was demonstrated the concentration-dependent inhibition of the growth against both cancer and normal cell lines. The results exhibited concentration-dependent inhibition of the growth of Hela, A 549, and MCF7 cancer cells (IC₅₀ = 65.0, 57.4, and 71.8 µg/mL, respectively), which were statistically significant comparing control cells (IC₅₀ = 226.1 µg/mL). Furthermore, we observed that CuO NPs-induced programmed cell death in the cancer cells were mediated with the downregulation of Bcl2 and upregulation of bax, caspase-3. CuO NPs were verified to be a superb catalyst as they had excellent activity for the degradation of 99.6%, 98.7%, 96.6%, and 96.6% of Congo red, methylene blue, methylene orange, and rhodamine B as industrial dyes in 3, 6.5, 6.5, and 6.5 min, respectively. Overall, the present study nominates T. parthenium as a proper bio-agent in the biosynthesis of CuO NPs with powerful catalytic and antimicrobial activities as well as a cancer treatment.

PMID:37017848 | DOI:10.1007/s11356-023-26706-x

Environ Sci Pollut Res Int. 2023 Apr 5. doi: 10.1007/s11356-023-26757-0. Online ahead of print.

ABSTRACT

The restaurant business is gaining popularity for its capacity to alleviate numerous adverse environmental influences to achieve a competitive edge. Green restaurants can employ a distinctive brand strategy. Nevertheless, additional research is necessary to better understand customer behavior in this subject. This study explores the relationship between brand awareness and brand image, and brand performance from the consumer’s perspective. However, it is unknown how this connection is affected by the attitude of green restaurant brands. This research aims to address the research gaps by determining the structure and function of brand attitudes. This study handles the quantitative data analysis to fit the study problem. The data was collected through a questionnaire form, and the questionnaire was collected from the customers from twelve restaurants in Karachi city of Pakistan by utilizing random sampling. In sum, 290 samples were obtained and interpreted with SPSS (Statistical Package for the Social Sciences) and PLS (Partial Least Squares) to come up with the results of the study. According to the findings, restaurant customers’ observed brand awareness and brand image positively impact brand attitude. The results of the structural equation analysis revealed that brand awareness and brand image have a substantial impact on brand performance, whereas brand attitude has a profound effect on meditation. The adaptation of brand attitude to brand management has sparked a lot of interest in the incredibly competitive restaurant business. There is a good likelihood that green restaurants will ultimately find value in using the measuring tools and suggestions offered in this research to analyze and lead their marketing efforts. In practice, it is recommended that green restaurant management cultivate familiar brand awareness and preserve the brand image to create brand attitude and performance.

PMID:37017839 | DOI:10.1007/s11356-023-26757-0

Environ Monit Assess. 2023 Apr 5;195(5):539. doi: 10.1007/s10661-023-11080-5.

ABSTRACT

Faced with a potential risk of a colossal amount of sludge released into the Doce River basin in the most shocking Brazilian mining disaster, we proposed to assess the environmental risk from a new perspective: Understanding the mobilization of potentially toxic elements (PTE) with the geochemical fractions. Soil and sediment samples were taken in nine sites throughout the basin and characterized. The environmental risk was assessed from the PTE sequential extraction in three fractions: soluble, reducible, and oxidizable, in addition to the pseudo-total concentration. The potential mobile fraction (PMF) showed a considerable PTE mobilization from the soil and sediment samples. Principal component statistical analysis indicated the sludge as the single source of PTE. The risk assessment depended on the fractional distribution and the PTE enrichment degree in the affected samples. The fractional distribution contributed mainly to Mn, Sb, and Pb mobility, with PMF of 96%, 81%, and 100%, respectively. The mobilization of Cd, Co, Ag, Ni, Pb, Zn, and Cu was predominantly related to the degree of enrichment. The risk assessment from the geochemical fractions pointed to the magnitude of the disaster and the dispersion of PTE with severe effects on the affected populations. Therefore, more strongly enforced regulations in the basin are needed, in addition to the urgent use of more secure containment dams. It is also essential to emphasize the transferability of the design of this study to other environmental units in mining disaster conditions.

PMID:37017824 | DOI:10.1007/s10661-023-11080-5

Heart Fail Rev. 2023 Apr 5. doi: 10.1007/s10741-023-10308-3. Online ahead of print.

ABSTRACT

Major depression (MD) is prevalent in patients with heart failure (HF) and contributes to increased risk of hospitalization and mortality. The implementation of cognitive behavioral therapy (CBT) has become a key strategy for treating HF patients’ depression. We performed a comprehensive literature search for studies that evaluated the efficacy of adjunctive CBT compared to the standard of care (SOC) in HF patients with MD. The primary outcome was the depression scale (post-intervention and by the end of follow-up). The secondary outcomes were the quality of life (QoL), self-care scores, and 6-min walk test distance(6-MW). The standardized mean difference (SMD) and corresponding 95% confidence intervals (CIs) were calculated using the random-effects model. A total of 6 RCTs with 489 patients (244 in the CBT group and 245 in the SOC group) were included. As compared to the SOC, CBT was associated with a statistically significant improvement in the post-interventional depression scale (SMD: -0.45, 95%CI: -0.69, -0.21; P < 0.01) and by the end of follow-up (SMD: -0.68, 95%CI: -0.87, -0.49; P < 0.01). Furthermore, CBT significantly improved the QoL (SMD: -0.45, 95%CI: -0.65, -0.24; P < 0.01). However, there were no differences in the self-care scores (SMD: 0.17, 95%CI: -0.08, 0.42; P = 0.18) or in 6-MW (SMD: 0.45, 95%CI: -0.39, 1.28; P = 0.29) between the two groups. According to our meta-analysis of published clinical studies, CBT may be more effective than standard therapy at enhancing depression scores and quality of life. To assess the long-term clinical effects of CBT in heart failure patients, larger and more powerful RCTs are required.

PMID:37017817 | DOI:10.1007/s10741-023-10308-3

CJEM. 2023 Apr 5. doi: 10.1007/s43678-023-00487-1. Online ahead of print.

ABSTRACT

OBJECTIVE: Intubation practices changed during the COVID-19 pandemic to protect healthcare workers from transmission of disease. Our objectives were to describe intubation characteristics and outcomes for patients tested for SARS CoV-2 infection. We compared outcomes between patients testing SARS COV-2 positive with those testing negative.

METHODS: We conducted a health records review using the Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) registry. We included consecutive eligible patients who presented to one of 47 EDs across Canada between March 1, 2020 and June 20, 2021, were tested for SARS-CoV-2 and intubated in the ED. The primary outcome was the proportion of patients experiencing a post-intubation adverse event during the ED stay. Secondary outcomes included first-pass success, intubation practices, and hospital mortality. We used descriptive statistics to summarize variables with subgroup differences examined using t tests, z tests, or chi-squared tests where appropriate with 95% CIs.

RESULTS: Of 1720 patients with suspected COVID-19 who were intubated in the ED during the study period, 337 (19.6%) tested SARS-CoV-2 positive and 1383 (80.4%) SARS-CoV-2 negative. SARS-CoV-2 positive patients presented to hospital with lower oxygen levels than SARS-CoV-2 negative patients (mean pulse oximeter SaO2 86 vs 94%, p < 0.001). In total, 8.5% of patients experienced an adverse event post-intubation. More patients in the SARS-CoV-2 positive subgroup experienced post-intubation hypoxemia (4.5 vs 2.2%, p = 0.019). In-hospital mortality was greater for patients who experienced intubation-related adverse events (43.2 vs 33.2%, p = 0.018). There was no significant difference in adverse event-associated mortality by SARS-CoV-2 status. First-pass success was achieved in 92.4% of all intubations, with no difference by SARS-CoV-2 status.

CONCLUSIONS: During the COVID-19 pandemic, we observed a low risk of adverse events associated with intubation, even though hypoxemia was common in patients with confirmed SARS-CoV-2. We observed high rates of first-pass success and low rates of inability to intubate. The limited number of adverse events precluded multivariate adjustments. Study findings should reassure emergency medicine practitioners that system modifications made to intubation processes in response to the COVID-19 pandemic do not appear to be associated with worse outcomes compared to pre-COVID-19 practices.

PMID:37017802 | DOI:10.1007/s43678-023-00487-1

Int J Colorectal Dis. 2023 Apr 5;38(1):91. doi: 10.1007/s00384-023-04383-z.

ABSTRACT

INTRODUCTION: Educational status is used as a proxy for socioeconomic status. While lower levels of education are generally associated with poorer health, the data on the relationship between educational status and colorectal neoplasia is heterogenous. The aim of our study was to examine this relationship and to adjust the association between educational status and colorectal neoplasia for other health parameters.

METHODS: We included 5977 participants undergoing a screening colonoscopy in Austria. We split the cohort into patients with lower (n = 2156), medium (n = 2933), and higher (n = 459) educational status. Multivariable multilevel logistic regression models were fitted to evaluate the association between educational status and the occurrence of any or advanced colorectal neoplasia. We adjusted for age, sex, metabolic syndrome, family history, physical activity, alcohol consumption, and smoking status.

RESULTS: We found that the rates of any neoplasia (32%) were similar between the educational strata. However, patients with higher (10%) educational status evidenced significantly higher rates of advanced colorectal neoplasia compared to medium (8%) and lower (7%) education. This association remained statistically significant after multivariable adjustment. The difference was entirely driven by neoplasia in the proximal colon.

CONCLUSION: Our study found that higher educational status was associated with a higher prevalence of advanced colorectal neoplasia compared to medium and lower educational status. This finding remained significant even after adjusting for other health parameters. Further research is needed to understand the underlying reasons for the observed difference, especially with regard to the specific anatomical distribution of the observed difference.

PMID:37017795 | DOI:10.1007/s00384-023-04383-z

Trop Anim Health Prod. 2023 Apr 5;55(3):147. doi: 10.1007/s11250-023-03553-z.

NO ABSTRACT

PMID:37017782 | DOI:10.1007/s11250-023-03553-z

Clin Res Cardiol. 2023 Apr 5. doi: 10.1007/s00392-023-02181-9. Online ahead of print.

ABSTRACT

AIMS: This study was performed to compare haemodynamic properties of a novel transcatheter heart valve (THV) with two established valve technologies for treatment of failing surgical aortic bioprosthetic valves (SAV). The ALLEGRA THV has been recently described with a proven safety and performance profile.

METHODS AND RESULTS: The study was designed as a retrospective, single-centre study investigating 112 patients (77.7 ± 7.1 years, 53.8% female, STS score 6.8 ± 5.8% and logEuroSCORE I 27.4 ± 16.1%) with failing SAV. Patients were treated with the ALLEGRA THV (NVT, n = 24), the CoreValve/EvolutR (MTD, n = 64) or the Edwards Sapien/Sapien XT/Sapien 3 (EDW, n = 24). Adverse events, haemodynamic outcomes and patient safety were analysed according to VARC-3 definitions. Overall procedural success was high (94.6%), even though 58.9% of the treated SAV were classified as small (true inner diameter < 21 mm). After treatment, the mean pressure gradient was significantly reduced (baseline: 33.7 ± 16.5 mmHg, discharge: 18.0 ± 7.1 mmHg), with a corresponding increase in effective orifice area (EOA). The complication rates did not differ in between groups. There was a trend to lower mean transvalvular gradients after implantation of self-expanding THV with supra-annular valve function, despite a higher frequency of smaller SAVs in the NVT and MTD group. Additionally, comparison between NVT and MTD revealed statistically lower transvalvular gradients (NVT 14.9 ± 5.0 mmHg, MTD 18.7 ± 7.5 mmHg, p = 0.0295) in a subgroup analysis.

CONCLUSIONS: Valve-in-valve (ViV) treatment of failing SAV with supra-annular design like the ALLEGRA THV resulted in favourable haemodynamic outcomes with similar low clinical event rates and may therefore be an interesting alternative for VIV TAVI.

PMID:37017780 | DOI:10.1007/s00392-023-02181-9

Behav Genet. 2023 Apr 5. doi: 10.1007/s10519-023-10139-w. Online ahead of print.

ABSTRACT

Using individuals’ genetic data researchers can generate Polygenic Scores (PS) that are able to predict risk for diseases, variability in different behaviors as well as anthropomorphic measures. This is achieved by leveraging models learned from previously published large Genome-Wide Association Studies (GWASs) associating locations in the genome with a phenotype of interest. Previous GWASs have predominantly been performed in European ancestry individuals. This is of concern as PS generated in samples with a different ancestry to the original training GWAS have been shown to have lower performance and limited portability, and many efforts are now underway to collect genetic databases on individuals of diverse ancestries. In this study, we compare multiple methods of generating PS, including pruning and thresholding and Bayesian continuous shrinkage models, to determine which of them is best able to overcome these limitations. To do this we use the ABCD Study, a longitudinal cohort with deep phenotyping on individuals of diverse ancestry. We generate PS for anthropometric and psychiatric phenotypes using previously published GWAS summary statistics and examine their performance in three subsamples of ABCD: African ancestry individuals (n = 811), European ancestry Individuals (n = 6703), and admixed ancestry individuals (n = 3664). We find that the single ancestry continuous shrinkage method, PRScs (CS), and the multi ancestry meta method, PRScsx Meta (CSx Meta), show the best performance across ancestries and phenotypes.

PMID:37017779 | DOI:10.1007/s10519-023-10139-w

J Eat Disord. 2023 Apr 4;11(1):56. doi: 10.1186/s40337-023-00775-2.

ABSTRACT

BACKGROUND: Feeding and eating disorders are associated with significant illness burden and costs, yet access to evidence-based care is limited. Low intensity psychological interventions have the potential to increase such access.

METHODS: A systematic review and meta-analysis were conducted on the use of low intensity psychological interventions for the treatment of feeding and eating disorders. Studies comparing low intensity psychological interventions against high intensity therapies and non-eating disorder specific psychological interventions were included, as well as those with waiting list control arms. There were three primary outcomes: eating disorder psychopathology, diagnostic and statistical manual of mental disorders (DSM) severity specifier-related outcomes and rates of remission/recovery.

RESULTS: Thirty-three studies met the inclusion criteria, comprising 3665 participants, and 30 studies were included in the meta-analysis. Compared to high intensity therapies, low intensity psychological interventions were equivalent on reducing eating disorder psychopathology (g = – 0.13), more effective at improving DSM severity specifier-related outcomes (g = – 0.15), but less likely to achieve remission/recovery (risk ratio (RR) = 0.70). Low intensity psychological interventions were superior to non-eating disorder specific psychological interventions and waiting list controls across all three primary outcomes.

CONCLUSION: Overall, findings suggest that low intensity psychological interventions can successfully treat eating disorder symptoms. Few potential moderators had a statistically significant effect on outcome. The number of studies for many comparisons was low and the methodological quality of the studies was poor, therefore results should be interpreted with caution. More research is needed to establish the effectiveness of low intensity psychological interventions for children and young people, as well as for individuals with anorexia nervosa, avoidant/restrictive food intake disorder, pica and rumination disorder.

PMID:37016447 | DOI:10.1186/s40337-023-00775-2