Category: Nevin Manimala

IEEE Trans Image Process. 2023 Apr 18;PP. doi: 10.1109/TIP.2023.3267044. Online ahead of print.

ABSTRACT

Night-Time Scene Parsing (NTSP) is essential to many vision applications, especially for autonomous driving. Most of the existing methods are proposed for day-time scene parsing. They rely on modeling pixel intensity-based spatial contextual cues under even illumination. Hence, these methods do not perform well in night-time scenes as such spatial contextual cues are buried in the over-/under-exposed regions in night-time scenes. In this paper, we first conduct an image frequency-based statistical experiment to interpret the day-time and night-time scene discrepancies. We find that image frequency distributions differ significantly between day-time and night-time scenes, and understanding such frequency distributions is critical to NTSP problem. Based on this, we propose to exploit the image frequency distributions for night-time scene parsing. First, we propose a Learnable Frequency Encoder (LFE) to model the relationship between different frequency coefficients to measure all frequency components dynamically. Second, we propose a Spatial Frequency Fusion module (SFF) that fuses both spatial and frequency information to guide the extraction of spatial context features. Extensive experiments show that our method performs favorably against the state-of-the-art methods on the NightCity, NightCity+ and BDD100K-night datasets. In addition, we demonstrate that our method can be applied to existing day-time scene parsing methods and boost their performance on night-time scenes. The code is available at https://github.com/wangsen99/FDLNet.

PMID:37071518 | DOI:10.1109/TIP.2023.3267044

Acta Radiol. 2023 Apr 18:2841851231169173. doi: 10.1177/02841851231169173. Online ahead of print.

ABSTRACT

BACKGROUND: Computed tomography (CT) and magnetic resonance imaging (MRI) are indicated for use in preoperative planning and may complicate diagnosis and place a burden on patients with lumbar disc herniation.

PURPOSE: To investigate the diagnostic potential of MRI-based synthetic CT with conventional CT in the diagnosis of lumbar disc herniation.

MATERIAL AND METHODS: After obtaining prior institutional review board approval, 19 patients who underwent conventional and synthetic CT imaging were enrolled in this prospective study. Synthetic CT images were generated from the MRI data using U-net. The two sets of images were compared and analyzed qualitatively by two musculoskeletal radiologists. The images were rated on a 4-point scale to determine their subjective quality. The agreement between the conventional and synthetic images for a diagnosis of lumbar disc herniation was determined independently using the kappa statistic. The diagnostic performances of conventional and synthetic CT images were evaluated for sensitivity, specificity, and accuracy, and the consensual results based on T2-weighted imaging were employed as the reference standard.

RESULTS: The inter-reader and intra-reader agreement were almost moderate for all evaluated modalities (κ = 0.57-0.79 and 0.47-0.75, respectively). The sensitivity, specificity, and accuracy for detecting lumbar disc herniation were similar for synthetic and conventional CT images (synthetic vs. conventional, reader 1: sensitivity = 91% vs. 81%, specificity = 83% vs. 100%, accuracy = 87% vs. 91%; P < 0.001; reader 2: sensitivity = 84% vs. 81%, specificity = 85% vs. 98%, accuracy = 84% vs. 90%; P < 0.001).

CONCLUSION: Synthetic CT images can be used in the diagnostics of lumbar disc herniation.

PMID:37071506 | DOI:10.1177/02841851231169173

J Hypertens. 2023 Apr 18. doi: 10.1097/HJH.0000000000003430. Online ahead of print.

ABSTRACT

OBJECTIVE: To evaluate the impact of sacubitril/valsartan on blood pressure (BP), ventricular structure, and myocardial fibrosis compared with valsartan in perimenopausal hypertensive women.

METHODS: This prospective, randomized, actively controlled, open-label study included 292 women with perimenopausal hypertension. They were randomly divided into two groups: sacubitril/valsartan 200 mg once daily and valsartan 160 mg once daily for 24 weeks. The relevant indicators of ambulatory BP, echocardiography, and myocardial fibrosis regulation were assessed at baseline and at 24 weeks.

RESULTS: The 24-h mean SBP after 24 weeks of treatment was 120.08 ± 10.47 mmHg in the sacubitril/valsartan group versus 121.00 ± 9.76 mmHg in the valsartan group (P = 0.457). After 24 weeks of treatment, there was no difference in central SBP between the sacubitril/valsartan and valsartan groups (117.17 ± 11.63 versus 116.38 ± 11.58, P = 0.568). LVMI in the sacubitril/valsartan group was lower than that in the valsartan group at week 24 (P = 0.009). LVMI decreased by 7.23 g/m2 from the baseline in the sacubitril/valsartan group and 3.70 g/m2 in the valsartan group at 24 weeks (P = 0.000 versus 0.017). A statistically significant difference in LVMI between the two groups was observed at 24 weeks after adjusting for the baseline LVMI (P = 0.001). The levels of α-smooth muscle actin (α-SMA), connective tissue growth factor (CT-GF) and transforming growth factor-β (TGF-β) were reduced in the sacubitril/valsartan group compared with the baseline (P = 0.000, 0.005, and 0.000). LVMI between the two groups was statistically significant at 24 weeks after correcting for confounding factors 24-h mean SBP and 24-h mean DBP (P = 0.005). The LVMI, serum TGF-β, α-SMA, and CT-GF remained statistically significant between the two groups after further correcting the factors of age, BMI, and sex hormone levels (P < 0.05).

CONCLUSION: Sacubitril/valsartan could reverse ventricular remodeling more effectively than valsartan. The different effects of these two therapies on ventricular remodeling in perimenopausal hypertensive women might be because of their different effects on the down-regulation of fibrosis-related factors.

PMID:37071432 | DOI:10.1097/HJH.0000000000003430

JAMA Netw Open. 2023 Apr 3;6(4):e238701. doi: 10.1001/jamanetworkopen.2023.8701.

ABSTRACT

IMPORTANCE: Patients attending US abortion clinics may consider or try self-managing their abortion before coming to the clinic, yet little is known about the factors associated with self-management behavior.

OBJECTIVE: To examine the prevalence and factors associated with considering or attempting a self-managed abortion before attending a clinic.

DESIGN, SETTING, AND PARTICIPANTS: This survey study included patients obtaining an abortion at 49 independent, Planned Parenthood, and academic-affiliated clinics chosen to maximize diversity in geographic, state policy, and demographic context in 29 states between December 2018 and May 2020. Data were analyzed from December 2020 to July 2021.

EXPOSURES: Obtaining an abortion at a clinic.

MAIN OUTCOMES AND MEASURES: Knowledge of medications used to self-manage an abortion, having considered medication self-management before attending the clinic, having considered any method of self-management before attending the clinic, and having tried any method of self-management before attending the clinic.

RESULTS: The study included 19 830 patients, of which 99.6.% (17 823 patients) identified as female; 60.9% (11 834 patients) were aged 20 to 29 years; 29.6% (5824 patients) identified as Black, 19.3% (3799 patients) as Hispanic, and 36.0% (7095 patients) as non-Hispanic White; 44.1% (8252 patients) received social services; and 78.3% (15 197 patients) were 10 weeks pregnant or less. Approximately 1 in 3 (34%) knew about self-managed medication abortion, and among this subsample of 6750 patients, 1 in 6 (1079 patients [16.1%]) had considered using medications to self-manage before attending the clinic. Among the full sample, 1 in 8 (11.7%) considered self-managing using any method before clinic attendance, and among this subsample of 2328 patients, almost 1 in 3 (670 patients [28.8%]) attempted to do so. Preference for at-home abortion care was associated with considering medication self-management (odds ratio [OR], 3.52; 95% CI, 2.94-4.21), considering any method of self-management (OR, 2.80; 95% CI, 2.50-3.13), and attempting any method of self-management (OR, 1.37; 95% CI, 1.10-1.69). Experiencing clinic access barriers was also associated with considering medication self-management (OR, 1.98; 95% CI, 1.69-2.32) and considering any method of self-management (OR, 2.09; 95% CI, 1.89-2.32).

CONCLUSIONS AND RELEVANCE: In this survey study, considering self-managed abortion was common before accessing in-clinic care, particularly among those on the margins of access or with a preference for at-home care. These findings suggest a need for expanded access to telemedicine and other decentralized abortion care models.

PMID:37071424 | DOI:10.1001/jamanetworkopen.2023.8701

JAMA Netw Open. 2023 Apr 3;6(4):e238707. doi: 10.1001/jamanetworkopen.2023.8707.

ABSTRACT

IMPORTANCE: Recent information on the prevalence of prescription stimulant therapy for attention-deficit/hyperactivity disorder (ADHD) and nonmedical use of prescription stimulants (NUPS) at the school-level among US secondary school students is limited.

OBJECTIVE: To investigate the school-level prevalence of and association between stimulant therapy for ADHD and NUPS among US secondary school students.

DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study used survey data collected between 2005 and 2020 as part of the Monitoring the Future study (data collected annually via self-administered survey in schools from independent cohorts). Participants were from a nationally representative sample of 3284 US secondary schools. The mean (SD) response rates were 89.5% (1.3%) for 8th-grade students, 87.4% (1.1%) for 10th-grade students, and 81.5% (1.8%) for 12th-grade students. Statistical analysis was performed from July to September 2022.

MAIN OUTCOME AND MEASURE: Past-year NUPS.

RESULTS: The 3284 schools contained 231 141 US 8th-, 10th-, and 12th-grade students (111 864 [50.8%, weighted] female; 27 234 [11.8%, weighted] Black, 37 400 [16.2%, weighted] Hispanic, 122 661 [53.1%, weighted] White, 43 846 [19.0%, weighted] other race and ethnicity). Across US secondary schools, the past-year prevalence of NUPS ranged from 0% to more than 25%. The adjusted odds of an individual engaging in past-year NUPS were higher at secondary schools with higher proportions of students who reported stimulant therapy for ADHD, after controlling for other individual-level and school-level covariates. Students attending schools with the highest rates of prescription stimulant therapy for ADHD had approximately 36% increased odds of past-year NUPS compared with students attending schools with no medical use of prescription stimulants (adjusted odds ratio, 1.36; 95% CI, 1.20-1.55). Other significant school-level risk factors included schools in more recent cohorts (2015-2020), schools with higher proportions of parents with higher levels of education, schools located in non-Northeastern regions, schools located in suburban areas, schools with higher proportion of White students, and schools with medium levels of binge drinking.

CONCLUSIONS AND RELEVANCE: In this cross-sectional study of US secondary schools, the prevalence of past-year NUPS varied widely, highlighting the need for schools to assess their own students rather than relying solely on regional, state, or national results. The study offered new evidence of an association between a greater proportion of the student body that uses stimulant therapy and a greater risk for NUPS in schools. The association between greater school-level stimulant therapy for ADHD and other school-level risk factors suggests valuable targets for monitoring, risk-reduction strategies, and preventive efforts to reduce NUPS.

PMID:37071423 | DOI:10.1001/jamanetworkopen.2023.8707

Vector Borne Zoonotic Dis. 2023 Apr;23(4):247-255. doi: 10.1089/vbz.2022.0049. Epub 2023 Jan 27.

ABSTRACT

Background: In Poland, Lyme borreliosis (LB) has been subject to mandatory public health surveillance since 1996 and, in accordance with EU regulations, Lyme neuroborreliosis has been reported to the European Centre for Disease Prevention and Control since 2019. In this study, the incidence, temporal trends, and geographic distribution of LB and its manifestations in Poland are described for the period 2015-2019. Methods: This retrospective incidence study of LB and its manifestations in Poland was based on data sent to the National Institute of Public Health-National Institute of Hygiene-National Research Institute (NIPH-NIH-NRI) by district sanitary epidemiological stations using the electronic Epidemiological Records Registration System and data from the National Database on Hospitalization. Incidence rates were calculated using population data from the Central Statistical Office. Results: During 2015-2019, Poland reported 94,715 cases of LB with an overall average incidence of 49.3 cases per 100,000 population. Cases increased from 2015 (11,945) to 2016 (20,857) and then remained stable through 2019. Hospitalization due to LB also rose during these years. LB was more common among women (55.7%). Erythema migrans and Lyme arthritis were the most common manifestations of LB. The highest incidence rates occurred among >50-year-olds, with a peak in 65-69-year-olds. The highest number of cases was recorded in the third and fourth quarters of the year (July-December). Incidence rates in the eastern and northeastern regions of the country were higher than the national average. Conclusions: LB is endemic in all regions of Poland, and many regions reported high incidence rates. Large variations in spatially granular incidence rates highlight the need for targeted prevention strategies.

PMID:37071404 | DOI:10.1089/vbz.2022.0049

Acta Crystallogr D Struct Biol. 2023 May 1. doi: 10.1107/S2059798323002474. Online ahead of print.

ABSTRACT

26 well selected oxidized P-clusters (P²⁺) from the crystallographic data deposited in the Protein Data Bank have been analysed statistically by the bond-valence sum method with weighting schemes for MoFe proteins at different resolutions. Interestingly, the oxidation states of P²⁺ clusters correspond to Fe₂³⁺Fe₆²⁺ with high electron delocalization, showing the same oxidation states as the resting states of P-clusters (P^N) in nitrogenases. The previously uncertain reduction of P²⁺ to P^N clusters by two electrons was assigned as a double protonation of P²⁺, in which decoordination of the serine residue and the peptide chain of cysteine take place, in MoFe proteins. This is further supported by the obviously shorter α-alkoxy C-O bond (average of 1.398 Å) in P²⁺ clusters and longer α-hydroxy C-O bond (average of 1.422 Å) in P^N clusters, while no change is observed in the electronic structures of Fe₈S₇ Fe atoms in P-clusters. Spatially, the calculations show that Fe3 and Fe6, the most oxidized and most reduced Fe atoms, have the shortest distances of 9.329 Å from the homocitrate in the FeMo cofactor and 14.947 Å from the [Fe₄S₄] cluster, respectively, and may well function as important electron-transport sites.

PMID:37071394 | DOI:10.1107/S2059798323002474

Dermatol Ther (Heidelb). 2023 Apr 18. doi: 10.1007/s13555-023-00922-2. Online ahead of print.

ABSTRACT

BACKGROUND: Eosinophils, basophils, and the molecule CD23 on B cells are involved in the pathophysiology of atopic dermatitis (AD). The molecule CD23 is involved in the regulation of IgE synthesis and is expressed by activated B cells. The molecule CD16 is used to assess the activation of eosinophils and CD203 of basophils. The association between the count of eosinophils, basophils, CD16⁺ eosinophils, CD203⁺ basophils and the expression of the activation marker CD23 on B cells in patients with AD (with and without dupilumab therapy) is not described.

OBJECTIVE: The aim of this pilot study is to evaluate the association between the blood count of eosinophils, basophils, relative CD16⁺ eosinophils, relative CD203⁺ basophils, and the expression of molecule CD23 on B cells and on their subsets (total, memory, naive, switched, non-switched) in patients suffering from AD (with and without dupilumab therapy) and in control group.

METHODS: A total of 45 patients suffering from AD were examined; 32 patients without dupilumab treatment (10 men, 22 women, average age 35 years), 13 patients with dupilumab treatment (7 men, 6 women, average age 43.4 years), and 30 subjects as a control group (10 men, 20 women, average age 44.7 years). Immunophenotype was examined by flow cytometry in which monoclonal antibodies with fluorescent molecules were used. For statistical analysis we used non-parametric Kruskal-Wallis one-factor analysis of variance with post hoc by Dunn’s test with Bonferroni modification and the Spearman’s rank correlation coefficient; for coefficients higher than 0.41, we report R² (percent of variation explained).

RESULTS: The absolute count of eosinophils was significantly higher in patients with AD (with and without dupilumab) in comparison to healthy subjects. The difference in the relative count of CD16⁺ eosinophils in patients with AD (with and without dupilumab therapy) compared with control is not statistically significant. In patients with dupilumab therapy the significantly lower count of relative CD203⁺ basophils was confirmed compared with control. The higher association between the count of eosinophils (absolute and relative) and the expression of CD23 marker on B cells was confirmed in patients with dupilumab therapy; in contrast, this association was low in patients with AD without dupilumab therapy and in healthy subjects.

CONCLUSION: The higher association between the count of eosinophils (absolute and relative) and the expression of CD23 marker on B cells was confirmed in patients with AD under dupilumab therapy. It suggests that IL-4 production by eosinophils may play a role in B lymphocyte activation. The significantly lower count of CD203⁺ basophils has been demonstrated in patients with dupilumab therapy. This reduction of CD203⁺ basophil count may contribute to the therapeutic effects of dupilumab by reducing the inflammatory response and allergic reactions in patients with AD.

PMID:37071375 | DOI:10.1007/s13555-023-00922-2

J Epidemiol Glob Health. 2023 Apr 18. doi: 10.1007/s44197-023-00099-z. Online ahead of print.

ABSTRACT

Stomach (gastric) cancer is one of the most prevalent and deadly cancers worldwide and most gastric cancers are adenocarcinomas. Based on prior research, there is an association between Helicobacter pylori (H. pylori) infection together with the frequency of duodenal ulcer, distal gastric adenocarcinoma, mucosa-associated lymphoid tissue (MALT) lymphoma, and antral gastritis. Helicobacter pylori virulence and toxicity factors have been identified before that significantly influence the clinical outcomes of H. pylori infection and gastric adenocarcinoma. However, it remains unclear exactly how different strains of H. pylori affect gastric adenocarcinoma. Current research suggests this involves tumor suppressor genes, like p27 but also H. pylori toxic virulence proteins. Therefore, we quantified known H. pylori genotypes within adenocarcinoma patients to establish the prevalence of known toxins that include cytotoxin-associated gene A (cagA) as well as vacuolating cytotoxin A (vacA) within patients of variable adenocarcinoma diagnosis. This analysis used gastrectomy samples validated for DNA viability. The incidence of H. pylori in adenocarcinoma patients in Jordan was established to be 54.5% positive (ureA gene positive) with cagA genotype occurrence at 57.1%, but also in this population study vacA gene ratios found to be 24.7%:22.1%:14.3%:14.3%. (vacAs1:vacAs2:vacAm1:vacAm2). Using immunohistochemistry (IHC), we confirmed with statistical significance that p27 was dysregulated and suppressed, within nearly all H. pylori vacA genotypes. In addition, within 24.6% of H. pylori samples analyzed was a different bacterial genotype, and curiously that p27 protein expression was retained in 12% of tested adenocarcinoma H. pylori samples. This is suggestive that p27 could be used as a prognostic indicator but also that an unknown genotype could be contributing to the regulatory effects of p27 protein within this bacterial and cellular environment that may include other virulence factors and unknown immune system regulatory changes.

PMID:37071369 | DOI:10.1007/s44197-023-00099-z

Environ Sci Pollut Res Int. 2023 Apr 18. doi: 10.1007/s11356-023-26898-2. Online ahead of print.

ABSTRACT

The study projects climate over the Upper Indus Basin (UIB), covering geographic areas in India, Pakistan, Afghanistan, and China, under the two Representative Concentration Pathways (RCPs), viz., RCP4.5 and RCP8.5 by the late twenty-first century using the best-fit climate model validated against the climate observations from eight meteorological stations. GFDL CM3 performed better than the other five evaluated climate models in simulating the climate of the UIB. The model bias was significantly reduced by the Aerts and Droogers statistical downscaling method, and the projections overall revealed a significant increase in temperature and a slight increase in precipitation across the UIB comprising of Jhelum, Chenab, and Indus sub-basins. According to RCP4.5 and RCP8.5, the temperature and precipitation in the Jhelum are projected to increase by 3 °C and 5.2 °C and 0.8% and 3.4% respectively by the late twenty-first century. The temperature and precipitation in the Chenab are projected to increase by 3.5 °C and 4.8 °C and 8% and 8.2% respectively by the late twenty-first century under the two scenarios. The temperature and precipitation in the Indus are projected to increase by 4.8 °C and 6.5 °C and 2.6% and 8.7% respectively by the late twenty-first century under RCP4.5 and RCP8.5 scenarios. The late twenty-first century projected climate would have significant impacts on various ecosystem services and products, irrigation and socio-hydrological regimes, and various dependent livelihoods. It is therefore hoped that the high-resolution climate projections would be useful for impact assessment studies to inform policymaking for climate action in the UIB.

PMID:37071365 | DOI:10.1007/s11356-023-26898-2