Category: Nevin Manimala

Zhonghua Wei Chang Wai Ke Za Zhi. 2022 Apr 25;25(4):342-347. doi: 10.3760/cma.j.cn441530-20220217-00051.

ABSTRACT

Objective: To analyze the association of No.11p posterior lymph node metastasis with clinicopathological features and its prognostic significance in gastric cancer. Methods: A single-center retrospective cohort study was conducted. Clinicopathological data of patients with primary gastric cancers undergoing No.11p posterior lymph node dissection from January 2016 to December 2020 were retrieved from the Database of Gastric Cancer, West China Hospital, Sichuan University. Case inclusion criteria: (1) gastric cancer proved by pathology; (2) radical resection with intraoperative No.11p posterior lymph node dissection; (3) operations performed by the same surgical team; (4) no previous history of other malignant tumors and no concurrent malignant tumors. Those with stump gastric cancer, history of gastrectomy, neoadjuvant chemotherapy, incomplete clinicopathological data and lost to follow-up were excluded. During the operation, the upper edge of the pancreas was retracted forward to expose the area between the upper edge of the pancreas and the splenic vessels. The proximal segment of the splenic artery was skeletonized to remove lymphatic tissue anterior and superior to the splenic artery for No.11p lymph node dissection. For patients with lymphadenopathy in the area between the splenic artery and the splenic vein, dissection was performed. The enlarged lymph nodes were labeled with titanium clips and named as No.11p posterior lymph node. Pathological examination was performed separately after the specimen was isolated. Statistical analysis was performed using R software. Results: A total of 127 gastric cancer patients, who underwent No.11p posterior lymph nodes dissection were included in this study, of which 120 patients without No.11p posterior lymph nodes metastasis (No.11p posterior lymph nodes negative) and 7 patients with No.11p posterior lymph nodes metastasis (No.11p posterior lymph nodes positive). A total of 8 metastatic No.11p posterior lymph nodes were detected in 7 patients, metastasis rate and with a ratio of 5.5% (7/127) and 6.8% (8/127), respectively. In the subgroup analysis of T3-4 stage patients, the metastasis rate and ratio of No.11p posterior lymph nodes were 9.0% (7/78) and 10.7% (8/75), respectively. Compared to negative cases, patients with No.11p posterior lymph nodes metastasis had larger tumor (P=0.002), higher proportion of Borrmann type Ⅲ and Ⅳ tumors (P=0.005), more metastatic lymph nodes (P<0.001), more advanced T stage (P=0.043), N stage (P=0.004) and TNM stage (P=0.015). In survival analysis, patients with No.11p posterior lymph node metastasis had a significantly worse prognosis than those without metastasis after adjusting for TNM stage (hazard ratio=3.009, 95% confidence interval: 1.824-4.964, P<0.001). Conclusions: The No.11p posterior lymph node metastasis in gastric cancer is associated with worse prognosis. For patients of T3-4 stage gastric cancer, No.11p posterior lymph node dissection should be emphasized during radical operation.

PMID:35461203 | DOI:10.3760/cma.j.cn441530-20220217-00051

Zhonghua Wei Chang Wai Ke Za Zhi. 2022 Apr 25;25(4):336-341. doi: 10.3760/cma.j.cn441530-20210520-00214.

ABSTRACT

Objective: To investigate the safety and efficacy of pelvic peritoneal reconstruction and its effect on anal function in laparoscopy-assisted anterior resection of low and middle rectal cancer. Methods: A prospective cohort study was conducted. Consecutive patients with low and middle rectal cancer who underwent laparoscopy-assisted transabdominal anterior resection at Naval Military Medical University Changhai Hospital from February 2020 to February 2021 were enrolled. Inclusion criteria: (1) the distance from tumor to the anal verge ≤10 cm; (2) laparoscopy-assisted transabdominal anterior resection of rectal cancer; (3) complete clinical data; (4) rectal adenocarcinoma diagnosed by postoperative pathology. Exclusion criteria: (1) emergency surgery; (2) patients with a history of anal dysfunction or anal surgery; (3) preoperative diagnosis of distant (liver, lung) metastasis; (4) intestinal obstruction; (5) conversion to open surgery for various reasons. The pelvic floor was reconstructed using SXMD1B405 (Stratafix helical PGA-PCL, Ethicon). The first needle was sutured from the left anterior wall of the neorectum to the right. Insertion of the needle was continued to suture the root of the sigmoid mesentery while the Hemo-lok was used to fix the suture. The second needle was started from the beginning of the first needle, after 3-4 needles, a drainage tube was inserted through the left lower abdominal trocar to the presacral space. Then, the left peritoneal incision of the descending colon was sutured, after which Hemo-lok fixation was performed. The operative time, perioperative complications, postoperative Wexner anal function score and low anterior resection syndrome (LARS) score were compared between the study group and the control group. Three to six months after the operation, pelvic MRI was performed to observe and compare the pelvic floor anatomical structure of the two groups. Results: A total of 230 patients were enrolled, including 58 who underwent pelvic floor peritoneum reconstruction as the study group and 172 who did not undergo pelvic floor peritoneum reconstruction as the control group. There were no significant differences in general data between the two groups (all P>0.05). The operation time of the study group was longer than that of control group [(177.5±33.0) minutes vs. (148.7±45.5) minutes, P<0.001]. There was no significant difference in the incidence of perioperative complications (including anastomotic leakage, anastomotic bleeding, postoperative pneumonia, urinary tract infection, deep vein thrombosis, and intestinal obstruction) between the two groups (all P>0.05). Eight cases had anastomotic leakage, of whom 2 cases (3.4%) in the study group were discharged after conservative treatment, 5 cases (2.9%) of other 6 cases (3.5%) in the control group were discharged after the secondary surgical treatment. The Wexner score and LARS score were 3.1±2.8 and 23.0 (16.0-28.0) in the study group, which were lower than those in the control group [4.7±3.4 and 27.0 (18.0-32.0)], and the differences were statistically significant (t=-3.018, P=0.003 and Z=-2.257, P=0.024). Severe LARS was 16.5% (7/45) in study group and 35.5% (50/141) in control group, and the difference was no significant differences (Z=4.373, P=0.373). Pelvic MRI examination 3 to 6 months after surgery showed that the incidence of intestinal accumulation in the pelvic floor was 9.1% (3/33) in study group and 46.4% (64/138) in control group (χ(2)=15.537, P<0.001). Conclusion: Pelvic peritoneal reconstruction using stratafix in laparoscopic anterior resection of middle and low rectal cancer is safe and feasible, which may reduce the probability of the secondary operation in patients with anastomotic leakage and significantly improve postoperative anal function.

PMID:35461202 | DOI:10.3760/cma.j.cn441530-20210520-00214

Arch Gerontol Geriatr. 2022 Apr 15;101:104705. doi: 10.1016/j.archger.2022.104705. Online ahead of print.

ABSTRACT

BACKGROUND: Frailty is a syndrome commonly associated with old age. Social relationships are an essential determinant of frailty progression, and frailty can negatively affect social relationships.

OBJECTIVES: To identify social relationship types among older adults in Europe; to evaluate whether social relationship types differ across European regions; and to assess the association between frailty status and social relationship type.

METHODS: We used data from 56,226 individuals from 17 European countries who participated in Wave 6 of the Survey of Health, Ageing and Retirement in Europe. We constructed social relationship types from social relationship variables (contacts frequency, perceived emotional support, participation in social activities, providing and receiving instrumental support) using latent class analysis (LCA). Associations between social relationship types and frailty were examined using multinomial regression analyses integrated with LCA.

RESULTS: We identified four social relationship types: ‘poor’; ‘frequent and emotionally close’; ‘frequent, emotionally close, and supportive’; and ‘frequent, emotionally close, and active’. Type 3 is also characterised by participation in sport/social clubs (in the northern region) or receiving support (in the eastern region). Participation in volunteering/charity activities (in the central and northern regions) and instrumental support provision (in the northern region) are Type 4’s characteristics as well. In all regions, being frail was associated with less active social relationships (Types 1, 2, and 3) relative to the more ‘active’ type (Type 4).

CONCLUSION: Frailty status was associated with social relationship types. The identified types may help tailor intervention programmes for older adults to prevent worsening frailty.

PMID:35461166 | DOI:10.1016/j.archger.2022.104705

J Sport Rehabil. 2022 Apr 23:1-9. doi: 10.1123/jsr.2021-0386. Online ahead of print.

ABSTRACT

CONTEXT: Weight-bearing test (WBT) is a noninvasive quantitative test which has been used recently to determine loading capability of the individuals. The aim of this study was to strengthen the evidence for using the WBT test for measuring weight-bearing capacity of the upper-extremity with the specific objective of examining the internal and external responsiveness and concurrent validity of the test in patients with triangular fibrocartilage complex injury.

DESIGN: Single-group repeated measures.

METHODS: Internal responsiveness was assessed using effect size statistics. The correlation coefficient was used to examine external responsiveness by testing 5 hypotheses regarding predefined correlations between the changes in the measurements. Concurrent validity was evaluated by analyzing correlations between the WBT and other measurements. Thirty-one patients with triangular fibrocartilage complex injury were included for the analysis of the concurrent validity. Eighteen patients who completed all measurements at baseline and at 3-month follow-up enrolled for the responsiveness analysis. Measurements included the WBT, pain intensity, grip strength, and upper extremity functional level.

RESULTS: The WBT test was able to detect statistically significant changes in weight-bearing capacity between baseline and follow-up (P = .0001). The effect size of the WBT was large. Three out of 5 hypotheses (60%) were confirmed, a good correlation was found between changes scores of the WBT and grip strength (r = .478; P < .05). There were significant correlations between the WBT and other measurements (r value range from -.401 to .742; P < .05). A higher correlation was found between the WBT and grip strength (r = .742; P = .0001).

CONCLUSIONS: The responsiveness and concurrent validity of the WBT test confirmed that it is able to measure change in weight-bearing capacity in patients with triangular fibrocartilage complex injury.

PMID:35461186 | DOI:10.1123/jsr.2021-0386

Int Immunopharmacol. 2022 Apr 20;109:108780. doi: 10.1016/j.intimp.2022.108780. Online ahead of print.

ABSTRACT

OBJECTIVE: Tofacitinib is an oral Janus kinase (JAK) inhibitor that has been marketed and approved in the USA for the clinical treatment of rheumatoid arthritis, psoriasis and other inflammatory and autoimmune diseases. A phase I clinical trial was conducted to compare the bioequivalence and safety of tofacitinib (Chia Tai Tianqing Pharmaceutical Group Co., Ltd.) and Xeljanz® (Pfizer Inc.) in healthy Chinese subjects, providing basis for the clinical application of tofacitinib.

METHODS: Healthy Chinese subjects (N = 32) were randomly assigned to two groups at a 1:1 ratio. Subjects orally took 5 mg tofacitinib or Xeljanz® per cycle in random sequence. Blood samples were collected at 15 sampling points per cycle, and plasma drug concentrations of tofacitinib or Xeljanz® were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and statistical analysis for the pharmacokinetic (PK) parameters. Subjects’ physical indicators were monitored during the whole process to evaluate drug safety.

RESULTS: The adjusted geometric mean ratios (GMRs) of the peak concentration (C_max), area under the curve (AUC) from time zero to the last measurable concentration (AUC_0-t) and AUC from time zero to observed infinity (AUC_0-∞) were all within the range of 80-125%. The other PK parameter values were similar. The above values were all meeting the bioequivalence criteria with well safety.

CONCLUSION: The pharmacokinetic parameters and safety profile of tofacitinib were similar to those of Xeljanz® in healthy Chinese subjects. Therefore, tofacitinib can be considered bioequivalent to Xeljanz®, and the findings of this trial will promote the clinical application of tofacitinib.

PMID:35461158 | DOI:10.1016/j.intimp.2022.108780

Foot (Edinb). 2021 Oct 29;51:101874. doi: 10.1016/j.foot.2021.101874. Online ahead of print.

ABSTRACT

OBJECTIVES: Compare the functional outcomes of comparative studies of ankle arthrodesis (AA) and total ankle replacements (TAR).

DESIGN: Systematic review using PRISMA guidelines.

DATA SOURCES: Medline, Cochrane and EMBASE databases in July 2020.

ELIGIBILITY CRITERIA: Studies that directly compared TAR and AA which reported patient reported outcomes measures (PROMs) of pain, function and quality of life.

DATA EXTRACTION AND SYNTHESIS: Two authors independently reviewed all papers. PROMs were allocated into pain, function or quality of life domains. Two summary statistics were created to allow for analysis of the PROMs. These statistics were the mean difference in post-operative score and the mean difference in the change of score.

RESULTS: 1323 papers were assessed of which 20 papers were included. 898 ankle arthrodesis and 1638 ankle replacements were evaluated. The mean follow up was 3.3 years (range 0.5-13.0 years). AA patients had a mean age of 55.7 (range 20-82) and TAR 62.5 (range 21-89). There was major heterogeneity in outcomes used. We were unable to find a significant difference between the reported change in PROMs following TAR and AA. 29.3% of PROMs and their subscores showed TAR had better outcomes, 68.7% showed no significant difference and only 2.0% showed AA to have better outcomes.

CONCLUSIONS: The majority of published studies found equality in patient reported outcomes following TAR and AA although the quality of the studies was of low-level evidence. There is an urgent need for randomised controlled studies to definitively answer this important clinical question.

PMID:35461152 | DOI:10.1016/j.foot.2021.101874

Cognition. 2022 Apr 20;225:105123. doi: 10.1016/j.cognition.2022.105123. Online ahead of print.

ABSTRACT

Statistical learning (SL) is considered a cornerstone of cognition. While decades of research have unveiled the remarkable breadth of structures that participants can learn from statistical patterns in experimental contexts, how this ability interfaces with real-world cognitive phenomena remains inconclusive. These mixed results may arise from the fact that SL is often treated as a general ability that operates uniformly across all domains, typically assuming that sensitivity to one kind of regularity implies equal sensitivity to others. In a preregistered study, we sought to clarify the link between SL and language by aligning the type of structure being processed in each task. We focused on the learning of trigram patterns using artificial and natural language statistics, to evaluate whether SL predicts sensitivity to comparable structures in natural speech. Adults were trained and tested on an artificial language incorporating statistically-defined syllable trigrams. We then evaluated their sensitivity to similar statistical structures in natural language using a multiword chunking task, which examines serial recall of high-frequency word trigrams-one of the building blocks of language. Participants’ aptitude in learning artificial syllable trigrams positively correlated with their sensitivity to high-frequency word trigrams in natural language, suggesting that similar computations span learning across both tasks. Short-term SL taps into key aspects of long-term language acquisition when the statistical structures-and the computations used to process them-are comparable. Better aligning the specific statistical patterning across tasks may therefore provide an important steppingstone toward elucidating the relationship between SL and cognition at large.

PMID:35461113 | DOI:10.1016/j.cognition.2022.105123

Foot (Edinb). 2021 Oct 26;51:101873. doi: 10.1016/j.foot.2021.101873. Online ahead of print.

ABSTRACT

INTRODUCTION: As E-scooter use is increasing with the introduction of urban rental schemes in the United Kingdom, associated foot and ankle injuries will become more prevalent. The aim of this study is to assess the injury pattern and injury severity of foot and ankle trauma associated with E-scooter use.

METHODS: A retrospective case analysis of all E-scooter foot and ankle injuries presenting to three London hospitals between 1st January and 31st December 2020 was conducted. Data including demographics, mechanism and location of injury sustained, management, duration of hospital stay and mortality were collected.

RESULTS: 20 patients were identified with a total of 27 foot and ankle fractures. Eight patients had fracture dislocations, four sustained open injuries and 45% (9/20) of patients required surgical treatment. Those travelling over 15.5 mph were significantly more likely to require operative intervention (70%) than those travelling below 15.5 mph (20%) (P < 0.033) and were more likely to have an open fracture (40% compared to 0%) (P < 0.0886), however the latter was not of statistical significance. 85% (17/20) of rider’s injuries involved the foot and/or ankle only. There were no mortalities at 30 days.

CONCLUSIONS: E-scooter use can cause serious foot and ankle injuries. Robust guidelines and legislation restricting top speeds and enforcing the wearing of protective clothing could be implemented. This may protect the E-scooter user from significant foot and ankle injury.

PMID:35461150 | DOI:10.1016/j.foot.2021.101873

Meat Sci. 2022 Apr 4;189:108813. doi: 10.1016/j.meatsci.2022.108813. Online ahead of print.

ABSTRACT

To compare the eating quality (EQ) of wet (WA) and dry aged (DA) mutton longissimus thoracis et lumborum (LTL) and semimembranosus (SM), bone-in leg and loin primals from 81 merino cull ewes were WA or DA for 14, 28, 42 or 56 days. Untrained consumers (n = 540) assessed the excised LTL and SM for EQ (tenderness, juiciness, liking of flavour and overall liking, 0-100), quality grade and respective willingness to pay (WTP). LTL scored higher than SM for EQ, P < 0.001 for all consumer sores. Mean LTL EQ scores were > 70 and mean SM EQ scores >54. Ageing method had no significant effect on LTL or SM EQ (P > 0.05 for all consumer scores). Ageing beyond 14 days improved SM and LTL tenderness. Consumers most often graded LTL and SM quality grades as “better than everyday” and “good everyday” respectively; corresponding WTP was 26.90 $AUD/kg and 18.80 $AUD/kg. Extended ageing periods improved mutton tenderness.

PMID:35461105 | DOI:10.1016/j.meatsci.2022.108813

Biomed Pharmacother. 2022 Apr 20;150:112939. doi: 10.1016/j.biopha.2022.112939. Online ahead of print.

ABSTRACT

Morus alba L. (White mulberry), is an important and popular herbal plant of the Moraceae family. It has been widely used due to its therapeutic properties, which include antidiabetic, antibacterial, anti-inflammatory, cardiovascular, and hypolpidemic activity. The present study evaluates the effects of aqueous white mulberry leaf extract on the transepithelial ion pathway in the rabbit colon epithelium (n = 48), using electrophysiological methods. In addition, the antioxidant potential and the chemical composition of the extract were determined. A mechanical-chemical stimulation with white mulberry in RH fluid (MB-RH) caused a statistically significant (p < 0.001) increase in the transepithelial electrical potential difference, from – 0.130 to – 0.685 mV. Gentle washing of the intestine with white mulberry in bumetanide, used as inhibitor of transepithelial chloride pathways, resulted in 14.8% shorter reaction than during MB-RH stimulation. There were no statistically significant differences between the electric potential values measured during stimulation with amiloride solution, used as inhibitor of transepithelial sodium pathways, and white mulberry in amilorid solution (p = 0.485). A short-term application of extract to the colon epithelium is responsible for local and reversible inhibition of chloride ion channels. The extract enhances sodium ion absorption and consequently changes the electrical potential. The effect of white mulberry extract on sodium ion transport may be related to the mechanism of hypoglycaemic activity of mulberry leaves.

PMID:35461088 | DOI:10.1016/j.biopha.2022.112939