Category: Nevin Manimala

JAMA Neurol. 2022 Aug 15. doi: 10.1001/jamaneurol.2022.2299. Online ahead of print.

ABSTRACT

IMPORTANCE: The evidence linking chronic kidney disease (CKD) to spontaneous intracerebral hemorrhage (ICH) is inconclusive owing to possible confounding by comorbidities that frequently coexist in patients with these 2 diseases.

OBJECTIVE: To determine whether there is an association between CKD and ICH risk.

DESIGN, SETTING, AND PARTICIPANTS: A 3-stage study that combined observational and genetic analyses was conducted. First, the association between CKD and ICH risk was tested in the Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study, a multicenter case-control study in the US. All participants with available data on CKD from ERICH were included. Second, this analysis was replicated in the UK Biobank (UKB), an ongoing population study in the UK. All participants in the UKB were included in this study. Third, mendelian randomization analyses were implemented in the UKB using 27 CKD-related genetic variants to test for genetic associations. ERICH was conducted from August 1, 2010, to August 1, 2017, and observed participants for 1 year. The UKB enrolled participants between 2006 and 2010 and will continue to observe them for 30 years. Data analysis was performed from November 11, 2019, to May 10, 2022.

EXPOSURES: CKD stages 1 to 5.

MAIN OUTCOMES AND MEASURES: The outcome of interest was ICH, ascertained in ERICH via expert review of neuroimages and in the UKB via a combination of self-reported data and International Statistical Classification of Diseases, Tenth Revision, codes.

RESULTS: In the ERICH study, a total of 2914 participants with ICH and 2954 controls who had available data on CKD were evaluated (mean [SD] age, 61.6 [14.0] years; 2433 female participants [41.5%]; 3435 male participants [58.5%]); CKD was found to be independently associated with higher risk of ICH (odds ratio [OR], 1.95; 95% CI, 1.35-2.89; P < .001). This association was not modified by race and ethnicity. Replication in the UKB with 1341 participants with ICH and 501 195 controls (mean [SD] age, 56.5 [8.1] years; 273 402 female participants [54.4%]; 229 134 male participants [45.6%]) confirmed this association (OR, 1.28; 95% CI, 1.01-1.62; P = .04). Mendelian randomization analyses indicated that genetically determined CKD was associated with ICH risk (OR, 1.56; 95% CI, 1.13-2.16; P = .007).

CONCLUSIONS AND RELEVANCE: In this 3-stage study that combined observational and genetic analyses among study participants enrolled in 2 large observational studies with different characteristics and study designs, CKD was consistently associated with higher risk of ICH. Mendelian randomization analyses suggest that this association was causal. Further studies are needed to identify the specific biological pathways that mediate this association.

PMID:35969388 | DOI:10.1001/jamaneurol.2022.2299

Zebrafish. 2022 Aug;19(4):119-130. doi: 10.1089/zeb.2022.0006.

ABSTRACT

Motility is a widely available parameter that can be used to assess sperm quality of aquatic species. Sperm from fishes with external fertilization usually undergo a dynamic and short-lived period of motility after activation. The common practice of assigning a single value at an arbitrary peak of motility presents challenges for reproducibility, community-level standardization, and comparisons across studies. This study aimed to explore statistical approaches to standardize motility reporting, and to develop an initial framework for community-level standards. Sperm samples from 14 zebrafish (Danio rerio) with a total of 21,705 cells were analyzed by use of computer-assisted sperm analysis with data collection starting at 10 s after activation at 5-s intervals for 50 s. Four common motility variables were selected for analyses: curvilinear velocity, straight-line velocity, beat cross frequency, and amplitude of lateral head displacement. Cluster analysis was used to evaluate sperm subpopulations within and among males over time, least-square means was used to explore temporal aspects, and the first derivative of the regression equations was used to calculate the rate of change for the motility parameters. Cluster analysis proved informative, but overlapping ephemeral clusters were not valuable for providing standardization options. Analysis of temporal aspects and rate of change indicated opportunities for standardization by reporting the overall motility-time functions or reporting during stable time windows instead of peak motility or at random times. These approaches could minimize the inconsistencies caused by male-to-male variation and dynamic changes of subpopulations while providing comparable information. An overall temporal framework was identified for motility reporting along the collection-processing-cryopreservation-thawing sequence to provide a basis to support efforts of community-level standardization.

PMID:35969383 | DOI:10.1089/zeb.2022.0006

Pain Ther. 2022 Aug 12. doi: 10.1007/s40122-022-00422-9. Online ahead of print.

ABSTRACT

BACKGROUND: With increasing life expectancy in China, the associated burden of low back and neck pain (spinal pain) on the healthcare system increases, posing a substantial public health challenge. This study aimed to investigate trends in spinal pain incidence across China from 1990 to 2019 and to predict incidence trends between 2020 and 2030.

METHODS: Data were derived from the Global Burden of Disease Study (GBD) 2019. The annual percentage change (APC) and average annual percentage change (AAPC) between 1990 and 2019 were calculated using Joinpoint regression analysis. The effects of age, period, and cohort on spinal pain were estimated by an age-period-cohort model. An autoregressive integrated moving average (ARIMA) model was used to forecast incidence trends from 2020 to 2030.

RESULTS: From 1990 to 2019, the age-standardized incidence rate (ASIR) of low back pain (LBP) significantly decreased in both male and female subjects, while the ASIR of neck pain (NP) slightly increased regardless of sex. Joinpoint regression analysis showed that the incidence rates of LBP decreased in all age groups, and incidence rates of NP increased after 45 years old among men and women. The age effects showed that the relative risks (RR) of LBP incidence increased with age, and the group aged 40-49 years had the highest RR for NP incidence, regardless of sex. Period effects showed that the risk of NP continuously increased with increasing time periods, but not in LBP. The cohort effect showed a continuously decreasing trend in later birth cohorts. The prediction results of the ARIMA model show that the ASIR of NP in both male and female subjects in China shows an increasing trend in the next 10 years, and the ASIR of LBP increased in male but decreased in female subjects.

CONCLUSION: Spinal pain has remained a major public health burden over the past 30 years in China and will likely increase further with population aging. Therefore, spinal pain should be a priority for future research on prevention and therapy, and is especially critical as the aging population increases in China.

PMID:35969366 | DOI:10.1007/s40122-022-00422-9

Psychon Bull Rev. 2022 Aug 15. doi: 10.3758/s13423-022-02069-1. Online ahead of print.

ABSTRACT

A tradition that goes back to Sir Karl R. Popper assesses the value of a statistical test primarily by its severity: was there an honest and stringent attempt to prove the tested hypothesis wrong? For “error statisticians” such as Mayo (1996, 2018), and frequentists more generally, severity is a key virtue in hypothesis tests. Conversely, failure to incorporate severity into statistical inference, as allegedly happens in Bayesian inference, counts as a major methodological shortcoming. Our paper pursues a double goal: First, we argue that the error-statistical explication of severity has substantive drawbacks; specifically, the neglect of research context and the specificity of the predictions of the hypothesis. Second, we argue that severity matters for Bayesian inference via the value of specific, risky predictions: severity boosts the expected evidential value of a Bayesian hypothesis test. We illustrate severity-based reasoning in Bayesian statistics by means of a practical example and discuss its advantages and potential drawbacks.

PMID:35969359 | DOI:10.3758/s13423-022-02069-1

Clin Anat. 2022 Aug 15. doi: 10.1002/ca.23942. Online ahead of print.

ABSTRACT

In recent years, the logistical challenges posed by the Covid-19 pandemic have prompted medical educators teaching gross anatomy to explore an expanded use of online instructional modalities. There is concern that this shift to online anatomy education in medical schools could affect long-term learning outcomes for future healthcare providers. In this systematic review, the educational effectiveness of online anatomy teaching is compared with traditional (“face-to-face”) teaching methods, specifically in terms of students’ academic performance and satisfaction. A search of four databases identified and screened one hundred and sixty-two studies. Subsequently, thirty-one studies were analyzed, including both (a) teaching outcome measures (test scores) and (b) student satisfaction ratings. Authors chose studies, extracted data, assessed quality and examined risk of bias. Nineteen studies compared students’ academic performances between online and face-to-face teaching methods. Twenty-six studies measured students’ levels of satisfaction in both teaching methods. Both qualitative and quantitative analyses of the data revealed comparable academic performances with no statistical difference between the two teaching methods, but a higher level of satisfaction with face-to-face teaching. The findings confirm that students can learn from online teaching but are more satisfied with face-to-face teaching. The authors conclude that online teaching cannot replace traditional teaching and there is no preference for one type of modality over the other. Therefore, a multi-modal learning approach combining online with face-to-face educational modalities for medical students could be efficient and successful.

PMID:35969356 | DOI:10.1002/ca.23942

Can J Public Health. 2022 Aug 15. doi: 10.17269/s41997-022-00676-y. Online ahead of print.

ABSTRACT

OBJECTIVE: Homelessness is a serious social and public health concern in Canada. Individuals experiencing homelessness face numerous health problems and barriers in accessing health services. Visual impairment can exacerbate the lower quality of life experienced by people who are homeless, but its incidence among this population has been poorly documented in the literature. Our study aimed to describe health and sociodemographic characteristics and determine their association with visual impairment, ocular pathology and uncorrected refractive errors in a homeless population in Montreal, Canada.

METHODS: This cross-sectional study was conducted between May 2019 and September 2020 in eight homeless shelters selected using a stratified random sampling approach on the island of Montreal. An eye examination was performed on all participants, who were also administered a survey on social determinants of health. Descriptive analysis was used to analyze survey data, and logistic regression was used for each of the three study outcomes.

RESULTS: A total of 124 individuals experiencing homelessness (93 men, 31 women) were recruited. Participants were mostly Caucasian (> 70%) with an average age of 48 years (standard deviation = 13 years). Our sample reported a high level of education (68% had a high school diploma or higher), a high level of health insurance coverage (77%), social assistance benefits (71%), and social support (over 50%). There was a high prevalence of chronic conditions including diabetes (14%), hypertension (25%), and HIV/AIDS (3%). Results from eye examinations showed a high prevalence of visual impairment (22%), ocular pathology (23%), and uncorrected refractive error (75%). Age was statistically significantly associated with each outcome variable.

CONCLUSION: Despite a high level of social and health support, individuals experiencing homelessness in Montreal, Canada, experience high levels of chronic conditions and visual impairment. Our study highlights the unmet need for eye healthcare among homeless populations, and that eye health can be a unique entry point for intervening with homeless populations.

PMID:35969355 | DOI:10.17269/s41997-022-00676-y

Can J Public Health. 2022 Aug 15. doi: 10.17269/s41997-022-00684-y. Online ahead of print.

ABSTRACT

OBJECTIVES: This study highlights how socioeconomic trends in the emergency department (ED) for low-acuity visits change with the onset of COVID-19, identifies societal inequities exacerbated by the pandemic, and demonstrates the geographical regions where these inequities occur.

METHODS: We accessed 1,285,000 ED visits from 12 different facilities across New Brunswick from January 2017 to October 2020. Using a deprivation index developed by Statistics Canada as a measure of socioeconomic status, and controlling for additional factors, we perform a logistic regression to determine the influence of the COVID-19 pandemic on low-acuity visits of individuals from the most deprived quintile (Q5). We constructed a heat map of New Brunswick to highlight regions of high deprivation.

RESULTS: The proportion of Q5 individuals in the ethnocultural composition domain accessing the ED for low-acuity visits increased from 22.91% to 24.72% with the onset of the pandemic. Our logistic regression showed the log odds of being considered Q5 in the ethnocultural composition domain when visiting the ED for a low-acuity reason increased by 6.3% if the visit occurred during the pandemic, and increased by 101.6% if the visit occurred in one of the 3 major regions of New Brunswick.

CONCLUSION: Individuals visiting EDs for low-acuity reasons during the COVID-19 pandemic were more likely to be from the most diverse quintile in the ethnocultural domain, and the inequities were concentrated in the most urban regions in New Brunswick. This demonstrates that urban areas are where inequities are disproportionately faced for ethnically diverse individuals and demonstrates where policies could be focused.

PMID:35969354 | DOI:10.17269/s41997-022-00684-y

Environ Sci Pollut Res Int. 2022 Aug 15. doi: 10.1007/s11356-022-22489-9. Online ahead of print.

ABSTRACT

The relationship between environmental strategy and environmental performance has been extensively analyzed in the environmental management literature. However, this relationship is spurious due to the inconsistence outcomes, lack of intervening mechanism, and scarcity of appropriate context. This study undertakes these considerations by exploring the underlying moderation-mediation mechanism through which proactive corporate environmental strategy affects corporate environmental performance. The hypotheses of the study were empirically tested on the data gathered from 147 ISO 14001:2015 certified firms in Pakistan. The data was statistically validated and then tested with Bootstrapping method using Preacher and Hayes Process Macros. The findings of the study revealed that a proactive corporate environmental strategy predicts corporate environmental performance through green product innovation. Moreover, the moderation hypothesis of the organizational structure variable in the nexus between proactive corporate environmental strategy and green product innovation was not supported in the full sample, whereas the split sample based on organizational size indicated moderation effects in the small firm’s sample. The findings of the study carry important implications for firms related to corporate environmental strategy and green product innovation strategy.

PMID:35969346 | DOI:10.1007/s11356-022-22489-9

Environ Sci Pollut Res Int. 2022 Aug 15. doi: 10.1007/s11356-022-22245-z. Online ahead of print.

ABSTRACT

The purpose of this research is to synthesize environmentally friendly nanosorbents for the novel adsorption of diesel range organics (DRO) from contaminated water. Central composite design (CCD) analysis of response surface methodology (RSM) was employed in a model fitting of the variables predicting the adsorption efficiency of Moringa oleifera-functionalized zerovalent iron particles (ZINPs) for the removal of DRO. The effects of the reaction parameters on the response were screened using 2⁴ factorial designs to determine the statistically significant independent variables. A quadratic model predicting the DRO adsorption efficiency of ZINPs with an F value of 276.84 (p value < 0.0001) was developed. Diagnostic plots show that the predicted values were in excellent agreement with actual experimental values (R² = 0.99). The maximum percentage removal of DRO of 92.6% was achieved after optimization, using the synthesized ZINPs after 8 h of contact between DRO substrates and ZINPs at pH of 8, the temperature of 25 °C, with an adsorbent dosage of 2 g/L and at composite desirability of 1. Characterization of ZINPs revealed the formation of quasi nanospheres and nanocubes with an average particle diameter of 50.9 ± 9.7, a crystallite size of 15.31 nm, a crystallinity index of 32.47% and a pore width of 75.69-88.59 nm. The adsorption equilibrium data modelling of ZINPs for adsorption of DRO was best described by Langmuir isotherm with the maximum monolayer coverage capacity of 7.194 mg/g. The separation factor [Formula: see text], indicated favourable adsorption. The adsorption kinetic data were consistent with pseudo-second-order kinetics indicating probable chemisorption.

PMID:35969341 | DOI:10.1007/s11356-022-22245-z

Physiother Theory Pract. 2022 Aug 13:1-9. doi: 10.1080/09593985.2022.2111674. Online ahead of print.

ABSTRACT

BACKGROUND: Individuals with fibromyalgia (FM) exhibit generalized hyperalgesia to pain stimuli, and physical activity (PA) is critical to manage FM symptoms.

PURPOSE: This study examined the relationship between exercise-induced muscle pain, symptom severity, and PA in 28 women with FM.

METHODS: Muscle pain rating (MPR) was assessed during 3 minutes of submaximal isometric handgrip exercise, whereas PA and symptom severity were evaluated via self-report questionnaires. The analysis examined the relationship between the variables, with the specific interest in the mediating role of PA in the relationship between exercise-induced muscle pain and symptom severity.

RESULTS: MPR was positively associated with symptom severity (b = 1.89; 95% CI = 0.01, 3.76; P = .048) and inversely associated with PA levels (b = -0.16; 95% CI = -0.30, -0.03; P = .021). PA levels were inversely associated with symptom severity (b = -7.94; 95% CI = -12.46, -3.42; P = .001). After statistically controlling for PA levels, the relationship between MPR and symptom severity was no longer significant (b = 0.60; Wald 95% CI = -1.05, 2.25; P = .474).

CONCLUSION: Results show the link between the variables, and specifically demonstrate that PA mediates the relationship between exercise-induced muscle pain and symptom severity.

PMID:35968757 | DOI:10.1080/09593985.2022.2111674